Preferential Selection and Contribution of Non-Structural Protein 1 (NS1) to the Efficient Transmission of Panzootic Avian Influenza H5N8 Virus Clades 2.3.4.4A and B in Chickens and Ducks.
H5N8
NS1
clade 2.3.4.4
ducks
evolution
highly pathogenic avian influenza virus
interferon antagonism
transmission
virulence
Journal
Journal of virology
ISSN: 1098-5514
Titre abrégé: J Virol
Pays: United States
ID NLM: 0113724
Informations de publication
Date de publication:
25 08 2021
25 08 2021
Historique:
pubmed:
24
6
2021
medline:
3
11
2021
entrez:
23
6
2021
Statut:
ppublish
Résumé
Highly pathogenic avian influenza virus H5N8 clade 2.3.4.4 caused outbreaks in poultry at an unprecedented global scale. The virus was spread by wild birds in Asia in two waves: clade 2.3.4.4A in 2014/2015 and clade 2.3.4.4B from 2016 up to today. Both clades were highly virulent in chickens, but only clade B viruses exhibited high virulence in ducks. Viral factors which contribute to virulence and transmission of these panzootic H5N8 2.3.4.4 viruses are largely unknown. The NS1 protein, typically composed of 230 amino acids (aa), is a multifunctional protein which is also a pathogenicity factor. Here, we studied the evolutionary trajectory of H5N8 NS1 proteins from 2013 to 2019 and their role in the fitness of H5N8 viruses in chickens and ducks. Sequence analysis and
Identifiants
pubmed: 34160261
doi: 10.1128/JVI.00445-21
pmc: PMC8387057
doi:
Substances chimiques
Cytokines
0
INS1 protein, influenza virus
0
Viral Nonstructural Proteins
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
e0044521Subventions
Organisme : Horizon-2020
ID : Delta Flu
Organisme : Deutsche Forschungsgemeinschaft (DFG)
ID : AB 567
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