The liver X receptor agonist LXR 623 restricts flavivirus replication.
Antiviral Agents
/ pharmacology
Cell Line, Tumor
Cell Proliferation
/ drug effects
Cytokines
/ genetics
Cytopathogenic Effect, Viral
/ drug effects
Cytoplasmic Vesicles
/ drug effects
Encephalitis Viruses, Tick-Borne
/ drug effects
Endoplasmic Reticulum
/ drug effects
Humans
Indazoles
/ pharmacology
Liver X Receptors
/ agonists
Virus Replication
/ drug effects
Zika Virus
/ drug effects
Flavivirus
LXR 623
Powassan virus
Zika virus
liver X receptor
virus restriction
Journal
Emerging microbes & infections
ISSN: 2222-1751
Titre abrégé: Emerg Microbes Infect
Pays: United States
ID NLM: 101594885
Informations de publication
Date de publication:
Dec 2021
Dec 2021
Historique:
pubmed:
25
6
2021
medline:
25
2
2023
entrez:
24
6
2021
Statut:
ppublish
Résumé
The vector-borne flaviviruses (VBFVs) are well known for causing great misery and death in humans worldwide. The VBFVs include those transmitted by mosquitos, such as Zika virus (ZIKV), dengue virus; and those transmitted by ticks including the tick-borne flavivirus serocomplex and Powassan virus (POWV). Two of our recent reports showed that intracranial POWV infection in the reservoir host,
Identifiants
pubmed: 34162308
doi: 10.1080/22221751.2021.1947749
pmc: PMC8259867
doi:
Substances chimiques
2-(2-chloro-4-fluorobenzyl)-3-(4-fluorophenyl)-7-(trifluoromethyl)-2H-indazole
0
Antiviral Agents
0
Cytokines
0
Indazoles
0
Liver X Receptors
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
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