Cohort profile: follow-up of a Berlin Aging Study II (BASE-II) subsample as part of the GendAge study.
general medicine (see Internal Medicine)
geriatric medicine
public health
vascular medicine
Journal
BMJ open
ISSN: 2044-6055
Titre abrégé: BMJ Open
Pays: England
ID NLM: 101552874
Informations de publication
Date de publication:
23 06 2021
23 06 2021
Historique:
entrez:
24
6
2021
pubmed:
25
6
2021
medline:
29
6
2021
Statut:
epublish
Résumé
The study 'Sex- and gender-sensitive prevention of cardiovascular and metabolic disease in older adults in Germany', the GendAge study, focuses on major risk factors for cardiovascular and metabolic diseases and on the development of major outcomes from intermediate phenotypes in the context of sex and gender differences. It is based on a follow-up examination of a subsample (older group) of the Berlin Aging Study II (BASE-II). The GendAge study assessments took place between 22 June 2018 and 10 March 2020. A total of 1100 participants (older BASE-II subsample, aged ≥65 years) with baseline data assessed at least by one of the BASE-II partner sites were investigated in the follow-up. These participants had a mean age of 75.6 years (SD ±3.8), with a mean follow-up at 7.4 years (SD ±1.5). Data from different domains such as internal medicine, geriatrics, immunology and psychology were collected, with a focus on cardiometabolic diseases and in the context of sex and gender differences. Diabetes mellitus type 2 was reported by 15.6% and 8.6% of men and women, respectively. In contrast, this disease was diagnosed in 20.7% of men and 13.3% of women, indicating that a substantial proportion of almost 30% was unaware of the disease. Echocardiography revealed that left ventricular ejection fraction was higher in women than in men, in agreement with previous reports. A gender questionnaire assessing sociocultural aspects implemented as part of the follow-up described here will allow to calculate a gender score and its evaluation based on the newly collected data. At the same time, the other BASE-II research foci established over the past 10 years will be continued and strengthened by the BASE-II transition into a longitudinal study with follow-up data on the older subsample. DRKS00016157.
Identifiants
pubmed: 34162642
pii: bmjopen-2020-045576
doi: 10.1136/bmjopen-2020-045576
pmc: PMC8230995
doi:
Banques de données
DRKS
['DRKS00016157']
Types de publication
Journal Article
Observational Study
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
e045576Investigateurs
Nikolaus Buchmann
(N)
Peter Eibich
(P)
Friederike Kendel
(F)
Maximilian König
(M)
Christina M Lill
(CM)
Maike Mangold
(M)
Ahmad Tauseef Nauman
(AT)
Kristina Norman
(K)
Graham Pawelec
(G)
Sarah Toepfer
(S)
Valentin Max Vetter
(VM)
Gert G Wagner
(GG)
Ursula Wilkenshoff
(U)
Kilian Wistuba-Hamprecht
(K)
Informations de copyright
© Author(s) (or their employer(s)) 2021. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.
Déclaration de conflit d'intérêts
Competing interests: None declared.
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