Hepatocyte TLR4 triggers inter-hepatocyte Jagged1/Notch signaling to determine NASH-induced fibrosis.
Journal
Science translational medicine
ISSN: 1946-6242
Titre abrégé: Sci Transl Med
Pays: United States
ID NLM: 101505086
Informations de publication
Date de publication:
23 06 2021
23 06 2021
Historique:
received:
04
08
2020
revised:
19
02
2021
accepted:
26
05
2021
entrez:
24
6
2021
pubmed:
25
6
2021
medline:
13
7
2021
Statut:
ppublish
Résumé
Aberrant hepatocyte Notch activity is critical to the development of nonalcoholic steatohepatitis (NASH)-induced liver fibrosis, but mechanisms underlying Notch reactivation in developed liver are unclear. Here, we identified that increased expression of the Notch ligand Jagged1 (
Identifiants
pubmed: 34162749
pii: 13/599/eabe1692
doi: 10.1126/scitranslmed.abe1692
pmc: PMC8792974
mid: NIHMS1770984
pii:
doi:
Substances chimiques
Jagged-1 Protein
0
Receptors, Notch
0
TLR4 protein, human
0
Tlr4 protein, mouse
0
Toll-Like Receptor 4
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : NIDDK NIH HHS
ID : U01 DK061732
Pays : United States
Organisme : NIDDK NIH HHS
ID : R01 DK103818
Pays : United States
Organisme : NIDDK NIH HHS
ID : R01 DK119767
Pays : United States
Organisme : NIDDK NIH HHS
ID : R01 DK116620
Pays : United States
Organisme : NIDDK NIH HHS
ID : U01 DK061730
Pays : United States
Organisme : NIDDK NIH HHS
ID : U24 DK061730
Pays : United States
Informations de copyright
Copyright © 2021 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works.
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