Assessment of Airway Remodeling Using Endobronchial Ultrasound in Asthma-COPD Overlap.
airway remodeling
asthma-COPD overlap
bronchial wall layers
endobronchial ultrasound
total bronchial wall
Journal
Journal of asthma and allergy
ISSN: 1178-6965
Titre abrégé: J Asthma Allergy
Pays: New Zealand
ID NLM: 101543450
Informations de publication
Date de publication:
2021
2021
Historique:
received:
12
02
2021
accepted:
30
04
2021
entrez:
24
6
2021
pubmed:
25
6
2021
medline:
25
6
2021
Statut:
epublish
Résumé
The aim of this study was to evaluate the structural changes of the airways using the endobronchial ultrasound (EBUS) in ACO patients compared to severe asthma and COPD patients. The study included 17 patients with ACO, 17 patients with COPD and 33 patients with severe asthma. Detailed clinical data were obtained from all participants. Basic laboratory tests were performed, including measurement of eosinophil counts in blood and serum immunoglobulin E (IgE) concentrations. All patients underwent spirometry and bronchoscopy with EBUS (a 20‑MHz ultrasound probe) to measure the total thicknesses of the bronchial walls and their particular layers in segmental bronchi of the right lower lobe. EBUS allows to distinguish five layers of the bronchial wall. Layer 1 (L In patients with ACO the thicknesses of the L The process of structural changes in the airways assessed by EBUS is more advanced in individuals with ACO compared to patients with COPD, and less pronounced compared to patients with severe asthma. It seems that EBUS may provide useful information about differences in airway remodeling between ACO, COPD and severe asthma.
Identifiants
pubmed: 34163179
doi: 10.2147/JAA.S306421
pii: 306421
pmc: PMC8214023
doi:
Types de publication
Journal Article
Langues
eng
Pagination
663-674Informations de copyright
© 2021 Górka et al.
Déclaration de conflit d'intérêts
The authors report no conflicts of interest in this work.
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