Asian Pacific Society of Cardiology Consensus Recommendations on the Use of MitraClip for Mitral Regurgitation.

Transcatheter mitral valve repair with the MitraClip, a catheter-based percutaneous edge-to-edge repair technique to correct mitral regurgitation (MR), has been demonstrated in Western studies to be an effective and safe MR treatment strategy. However, randomised clinical trial data on its use in Asian-Pacific patients is limited. Hence, the Asian Pacific Society of Cardiology convened an expert panel to review the available literature on MitraClip and to develop consensus recommendations to guide clinicians in the region. The panel developed statements on the use of MitraClip for the management of degenerative MR, functional MR, and other less common indications, such as acute MR, dynamic MR, hypertrophic obstructive cardiomyopathy, and MR after failed surgical repair. Each statement was voted on by each panel member and consensus was reached when 80% of experts voted 'agree' or 'neutral'. This consensus-building process resulted in 10 consensus recommendations to guide general cardiologists in the evaluation and management of patients in whom MitraClip treatment is being contemplated.

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Disclosure: This work was funded through Asian Pacific Society of Cardiology by unrestricted educational grants from Abbott Vascular, Amgen, AstraZeneca, Bayer and Roche Diagnostics. YKK has received research funding from Medtronic, Boston Scientific, Amgen, AstraZeneca and Shockwave Medical (all significant, via institution); consulting or honoraria fees (all modest) from Medtronic, Boston Scientific, Abbott Vascular, Amgen, Bayer and Novartis; and speaker or proctor fees from Abbott Vascular, Boston Scientific, Medtronic, Philips, Shockwave Medical, Alvimedica, Menarini, AstraZeneca, Amgen and Bayer. JWCT has received honoraria from AstraZeneca, Bayer, Amgen, Medtronic, Abbott Vascular, Biosensors, Alvimedica, Boehringer Ingelheim and Pfizer; research and educational grants from Medtronic, Biosensors, Biotronik, Philips, Amgen, AZ, Roche, Ostuka, Terumo and Abbott Vascular; and consulting fees from Elixir, CSL Behring. ET and SHS have received honoraria from Abbott Vascular. JL has received research funding from AstraZeneca, Sensible Medical and Volumetrix; and consulting fees from Abbott, Amgen, AstraZeneca, Boehringer Ingelheim, Boston Scientific, CVRx, Edwards Lifesciences, Impulse Dynamics and VWave. XP has received proctor fees from Medtronic and Abbott Vascular. DWMM has received research funding and consulting or proctor fees from Abbott Vascular, Medtronic and Edwards Lifesciences. KM has received modest research funding and consulting or proctor fees from CSL Behring, Boston Scientific, Abbott Vascular, Medtronic, Thai Osuka, AstraZeneca and Daiichi Sankyo. SHE has received speaker fees from Edwards Lifesciences and Abbott Vascular. MA has received speaker fees from Abbott Medical Japan. JSK has received proctoring fees from Abbott Vascular and Occlutech. All other authors have no conflicts of interest to declare.