Anomalous structural dynamics of minimally frustrated residues in cardiac troponin C triggers hypertrophic cardiomyopathy.


Journal

Chemical science
ISSN: 2041-6520
Titre abrégé: Chem Sci
Pays: England
ID NLM: 101545951

Informations de publication

Date de publication:
29 Apr 2021
Historique:
entrez: 24 6 2021
pubmed: 25 6 2021
medline: 25 6 2021
Statut: epublish

Résumé

Cardiac TnC (cTnC) is highly conserved among mammals, and genetic variants can result in disease by perturbing Ca

Identifiants

pubmed: 34163821
doi: 10.1039/d1sc01886h
pii: d1sc01886h
pmc: PMC8171346
doi:

Types de publication

Journal Article

Langues

eng

Pagination

7308-7323

Informations de copyright

This journal is © The Royal Society of Chemistry.

Déclaration de conflit d'intérêts

There are no conflicts to declare.

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Auteurs

Mayra A Marques (MA)

Institute of Medical Biochemistry Leopoldo de Meis, National Institute of Structural Biology and Bioimaging, National Center of Nuclear Magnetic Resonance Jiri Jonas, Federal University of Rio de Janeiro 373 Carlos Chagas Filho Av, Room: E-10 Rio de Janeiro RJ 21941-902 Brazil gaugusto@bioqmed.ufrj.br +55-21-3938-6756.

Maicon Landim-Vieira (M)

Department of Biomedical Sciences, Florida State University, College of Medicine 1115 West Call Street, Room: 1370 (lab) - 1350-H (office) Tallahassee FL 32306 USA jose.pinto@med.fsu.edu +1-850-645-0016.

Adolfo H Moraes (AH)

Department of Chemistry, Federal University of Minas Gerais Belo Horizonte MG Brazil.

Bin Sun (B)

Department of Cell and Molecular Physiology, Loyola University Chicago Maywood IL USA.

Jamie R Johnston (JR)

Department of Biomedical Sciences, Florida State University, College of Medicine 1115 West Call Street, Room: 1370 (lab) - 1350-H (office) Tallahassee FL 32306 USA jose.pinto@med.fsu.edu +1-850-645-0016.

Karissa M Dieseldorff Jones (KM)

Department of Biomedical Sciences, Florida State University, College of Medicine 1115 West Call Street, Room: 1370 (lab) - 1350-H (office) Tallahassee FL 32306 USA jose.pinto@med.fsu.edu +1-850-645-0016.

Elio A Cino (EA)

Department of Biochemistry and Immunology, Federal University of Minas Gerais Belo Horizonte MG Brazil.

Michelle S Parvatiyar (MS)

Department of Nutrition, Food and Exercise Sciences, Florida State University Tallahassee FL USA.

Isela C Valera (IC)

Department of Nutrition, Food and Exercise Sciences, Florida State University Tallahassee FL USA.

Jerson L Silva (JL)

Institute of Medical Biochemistry Leopoldo de Meis, National Institute of Structural Biology and Bioimaging, National Center of Nuclear Magnetic Resonance Jiri Jonas, Federal University of Rio de Janeiro 373 Carlos Chagas Filho Av, Room: E-10 Rio de Janeiro RJ 21941-902 Brazil gaugusto@bioqmed.ufrj.br +55-21-3938-6756.

Vitold E Galkin (VE)

Department of Physiological Sciences, Eastern Virginia Medical School Norfolk VA USA.

P Bryant Chase (PB)

Department of Biological Science, Florida State University Tallahassee FL USA.

Peter M Kekenes-Huskey (PM)

Department of Cell and Molecular Physiology, Loyola University Chicago Maywood IL USA.

Guilherme A P de Oliveira (GAP)

Institute of Medical Biochemistry Leopoldo de Meis, National Institute of Structural Biology and Bioimaging, National Center of Nuclear Magnetic Resonance Jiri Jonas, Federal University of Rio de Janeiro 373 Carlos Chagas Filho Av, Room: E-10 Rio de Janeiro RJ 21941-902 Brazil gaugusto@bioqmed.ufrj.br +55-21-3938-6756.

Jose Renato Pinto (JR)

Department of Biomedical Sciences, Florida State University, College of Medicine 1115 West Call Street, Room: 1370 (lab) - 1350-H (office) Tallahassee FL 32306 USA jose.pinto@med.fsu.edu +1-850-645-0016.

Classifications MeSH