Immunotherapy-Induced Acute Tubulointerstitial Nephritis.
acute tubular interstitial nephritis
cancer immunotherapy
immune checkpoint inhibitor
immune related adverse events
ipilimumab
melanoma
nephrotoxicity
nivolumab
Journal
Cureus
ISSN: 2168-8184
Titre abrégé: Cureus
Pays: United States
ID NLM: 101596737
Informations de publication
Date de publication:
31 May 2021
31 May 2021
Historique:
entrez:
24
6
2021
pubmed:
25
6
2021
medline:
25
6
2021
Statut:
epublish
Résumé
Due to its minimal side-effect profile, immunotherapy has become a popular choice for the treatment of advanced melanoma as compared to conventional chemotherapy. The most common side effects associated with immunotherapy include gastrointestinal, pulmonary, and dermatologic manifestations. However, there have been very few documented occurrences of nephrotoxic side effects. We present a case of a 73-year-old male with a past medical history of chronic kidney disease (CKD) stage 3A, metastatic uveal melanoma, and gastroesophageal reflux disease on pantoprazole who arrived at the intensive care unit with altered mental status and creatinine of 27 gm/dl (baseline creatinine of 3 gm/dl about one year prior), after receiving his first dose of ipilimumab and nivolumab approximately 21 days prior. Kidney biopsy demonstrated acute tubulointerstitial nephritis (ATIN). This case highlights the importance of recognizing acute tubulointerstitial nephritis as a side effect of immunotherapy for prompt diagnosis and early treatment.
Identifiants
pubmed: 34164249
doi: 10.7759/cureus.15358
pmc: PMC8214499
doi:
Types de publication
Case Reports
Langues
eng
Pagination
e15358Informations de copyright
Copyright © 2021, Parza et al.
Déclaration de conflit d'intérêts
The authors have declared that no competing interests exist.
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