Evaluating distributional regression strategies for modelling self-reported sexual age-mixing.

age mixing bayesian statistics distributional regression epidemiology global health none sexual behaviour sinh-arcsinh distribution

Journal

eLife
ISSN: 2050-084X
Titre abrégé: Elife
Pays: England
ID NLM: 101579614

Informations de publication

Date de publication:
24 06 2021
Historique:
received: 11 03 2021
accepted: 23 06 2021
pubmed: 25 6 2021
medline: 9 10 2021
entrez: 24 6 2021
Statut: epublish

Résumé

The age dynamics of sexual partnership formation determine patterns of sexually transmitted disease transmission and have long been a focus of researchers studying human immunodeficiency virus. Data on self-reported sexual partner age distributions are available from a variety of sources. We sought to explore statistical models that accurately predict the distribution of sexual partner ages over age and sex. We identified which probability distributions and outcome specifications best captured variation in partner age and quantified the benefits of modelling these data using distributional regression. We found that distributional regression with a sinh-arcsinh distribution replicated observed partner age distributions most accurately across three geographically diverse data sets. This framework can be extended with well-known hierarchical modelling tools and can help improve estimates of sexual age-mixing dynamics.

Identifiants

pubmed: 34165078
doi: 10.7554/eLife.68318
pii: 68318
pmc: PMC8263061
doi:
pii:

Types de publication

Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Subventions

Organisme : Bill and Melinda Gates Foundation
ID : OPP1164897
Organisme : Engineering and Physical Sciences Research Council
ID : EP/V002910/1
Organisme : Medical Research Council
ID : MR/R015600/1
Pays : United Kingdom
Organisme : NIAID NIH HHS
ID : R01 AI136664
Pays : United States
Organisme : Bill and Melinda Gates Foundation
ID : OPP1190661

Informations de copyright

© 2021, Wolock et al.

Déclaration de conflit d'intérêts

TW, SF, KR, TD, SG, JE No competing interests declared

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Auteurs

Timothy M Wolock (TM)

Department of Mathematics, Imperial College London, London, United Kingdom.

Seth Flaxman (S)

Department of Mathematics, Imperial College London, London, United Kingdom.

Kathryn A Risher (KA)

MRC Centre for Global Infectious Disease Analysis, School of Public Health, Imperial College London, London, United Kingdom.
London School of Hygiene & Tropical Medicine, London, United Kingdom.

Tawanda Dadirai (T)

Manicaland Centre for Public Health Research, Biomedical Research and Training Institute, Harare, Zimbabwe.

Simon Gregson (S)

MRC Centre for Global Infectious Disease Analysis, School of Public Health, Imperial College London, London, United Kingdom.
Manicaland Centre for Public Health Research, Biomedical Research and Training Institute, Harare, Zimbabwe.

Jeffrey W Eaton (JW)

MRC Centre for Global Infectious Disease Analysis, School of Public Health, Imperial College London, London, United Kingdom.

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Classifications MeSH