The human cerebellum is essential for modulating perceptual sensitivity based on temporal expectations.
cerebellum
human
neurodegenerative disorder
neuroscience
perception
temporal expectation
visual attention
Journal
eLife
ISSN: 2050-084X
Titre abrégé: Elife
Pays: England
ID NLM: 101579614
Informations de publication
Date de publication:
24 06 2021
24 06 2021
Historique:
received:
21
01
2021
accepted:
23
06
2021
pubmed:
25
6
2021
medline:
9
10
2021
entrez:
24
6
2021
Statut:
epublish
Résumé
A functional benefit of attention is to proactively enhance perceptual sensitivity in space and time. Although attentional orienting has traditionally been associated with cortico-thalamic networks, recent evidence has shown that individuals with cerebellar degeneration (CD) show a reduced reaction time benefit from cues that enable temporal anticipation. The present study examined whether the cerebellum contributes to the proactive attentional modulation in time of perceptual sensitivity. We tested CD participants on a non-speeded, challenging perceptual discrimination task, asking if they benefit from temporal cues. Strikingly, the CD group showed no duration-specific perceptual sensitivity benefit when cued by repeated but aperiodic presentation of the target interval. In contrast, they performed similar to controls when cued by a rhythmic stream. This dissociation further specifies the functional domain of the cerebellum and establishes its role in the attentional adjustment of perceptual sensitivity in time in addition to its well-documented role in motor timing.
Identifiants
pubmed: 34165079
doi: 10.7554/eLife.66743
pii: 66743
pmc: PMC8245126
doi:
pii:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : NINDS NIH HHS
ID : R01 NS092079
Pays : United States
Organisme : NINDS NIH HHS
ID : R35 NS116883
Pays : United States
Informations de copyright
© 2021, Breska and Ivry.
Déclaration de conflit d'intérêts
AB No competing interests declared, RI Senior editor, eLife
Références
Trends Cogn Sci. 1998 Sep 1;2(9):338-47
pubmed: 21227230
Nat Rev Neurosci. 2002 Mar;3(3):201-15
pubmed: 11994752
J Neurosci. 2020 Oct 7;40(41):7877-7886
pubmed: 32900836
Trends Cogn Sci. 2017 May;21(5):313-332
pubmed: 28385461
J Exp Psychol Hum Percept Perform. 2011 Feb;37(1):236-44
pubmed: 20718571
J Am Geriatr Soc. 2005 Apr;53(4):695-9
pubmed: 15817019
J Neurosci. 1993 Apr;13(4):1708-18
pubmed: 8463846
Trends Cogn Sci. 2021 Feb;25(2):137-150
pubmed: 33353800
J Exp Psychol Hum Percept Perform. 1992 Aug;18(3):849-60
pubmed: 1500880
J Cogn Neurosci. 1989 Spring;1(2):136-52
pubmed: 23968462
PLoS Biol. 2017 Feb 10;15(2):e2001665
pubmed: 28187128
Trends Cogn Sci. 2008 Jul;12(7):273-80
pubmed: 18539519
Annu Rev Psychol. 2020 Jan 4;71:221-249
pubmed: 31514578
Exp Brain Res. 2006 Feb;169(1):58-68
pubmed: 16273403
Nat Rev Neurosci. 2018 Jan;19(1):34-48
pubmed: 29213134
Neurology. 2006 Jun 13;66(11):1717-20
pubmed: 16769946
Ann N Y Acad Sci. 1984;423:52-77
pubmed: 6588812
J Cogn Neurosci. 2011 Nov;23(11):3318-30
pubmed: 21452942
Trends Neurosci. 2019 Jun;42(6):373-374
pubmed: 30885405
Cerebellum. 2007;6(3):177-83
pubmed: 17786813
J Acoust Soc Am. 1971 Feb;49(2):Suppl 2:467+
pubmed: 5541744
J Neurosci. 2016 Feb 24;36(8):2342-7
pubmed: 26911682
J Vis. 2014 Apr 10;14(4):
pubmed: 24722562
J Neurosci. 2006 May 17;26(20):5448-55
pubmed: 16707797
J Neurosci. 2008 Feb 27;28(9):2252-60
pubmed: 18305258
J Neurosci. 1999 Jul 1;19(13):5632-43
pubmed: 10377369
Psychon Bull Rev. 2005 Apr;12(2):328-34
pubmed: 16082814
J Mot Behav. 1993 Sep;25(3):203-16
pubmed: 12581990
J Neurosci. 1998 Sep 15;18(18):7426-35
pubmed: 9736662
Spat Vis. 1997;10(4):437-42
pubmed: 9176953
Science. 2003 May 30;300(5624):1437-9
pubmed: 12775842
J Cogn Neurosci. 2014 Mar;26(3):593-605
pubmed: 24168222
Proc Natl Acad Sci U S A. 2015 Jul 7;112(27):8439-44
pubmed: 26100913
Annu Rev Neurosci. 1990;13:25-42
pubmed: 2183676
Brain. 1999 Aug;122 ( Pt 8):1507-18
pubmed: 10430834
J Neurosci. 2012 Jun 13;32(24):8424-8428
pubmed: 22699922
Proc Natl Acad Sci U S A. 2018 Nov 27;115(48):12283-12288
pubmed: 30425170
Psychon Bull Rev. 2017 Aug;24(4):1142-1151
pubmed: 28054311
J Cogn Neurosci. 2001 Apr 1;13(3):285-97
pubmed: 11371307
Science. 1997 Mar 28;275(5308):1940-3
pubmed: 9072973
Sci Adv. 2020 Dec 2;6(49):
pubmed: 33268365
J Vis. 2019 Jan 2;19(1):12
pubmed: 30650437
Proc Natl Acad Sci U S A. 2010 Jun 22;107(25):11597-601
pubmed: 20534501
Spat Vis. 1997;10(4):433-6
pubmed: 9176952
Percept Psychophys. 1993 Sep;54(3):277-86
pubmed: 8414886
Brain Topogr. 2001 Spring;13(3):149-59
pubmed: 11302395
Neurosci Biobehav Rev. 2018 Mar;86:150-165
pubmed: 29223770