Entrainment of Network Activity by Closed-Loop Microstimulation in Healthy Ambulatory Rats.
activity-dependent stimulation
motor cortex
neuronal plasticity
neurophysiology
Journal
Cerebral cortex (New York, N.Y. : 1991)
ISSN: 1460-2199
Titre abrégé: Cereb Cortex
Pays: United States
ID NLM: 9110718
Informations de publication
Date de publication:
01 10 2021
01 10 2021
Historique:
received:
28
10
2020
revised:
22
04
2021
accepted:
23
04
2021
pubmed:
25
6
2021
medline:
1
4
2022
entrez:
24
6
2021
Statut:
ppublish
Résumé
As our understanding of volitional motor function increases, it is clear that complex movements are the result of the interactions of multiple cortical regions rather than just the output properties of primary motor cortex. However, our understanding of the interactions among these regions is limited. In this study, we used the activity-dependent stimulation (ADS) technique to determine the short/long-term effects on network activity and neuroplasticity of intracortical connections. ADS uses the intrinsic neural activity of one region to trigger stimulations in a separate region of the brain and can manipulate neuronal connectivity in vivo. Our aim was to compare single-unit neuronal activity within premotor cortex (rostral forelimb area, [RFA] in rats) in response to ADS (triggered from RFA) and randomly-generated stimulation in the somatosensory area (S1) within single sessions and across 21 consecutive days of stimulation. We examined firing rate and correlation between spikes and stimuli in chronically-implanted healthy ambulatory rats during spontaneous and evoked activity. At the end of the treatment, we evaluated changes of synaptophysin expression. Our results demonstrated the ability of ADS to modulate RFA firing properties and to promote synaptogenesis in S1, strengthening the idea that this Hebbian-inspired protocol can be used to modulate cortical connectivity.
Identifiants
pubmed: 34165137
pii: 6308680
doi: 10.1093/cercor/bhab140
pmc: PMC8491688
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
5042-5055Subventions
Organisme : NICHD NIH HHS
ID : R03 HD094608
Pays : United States
Organisme : NICHD NIH HHS
ID : T32 HD057850
Pays : United States
Organisme : NINDS NIH HHS
ID : R01 NS030853
Pays : United States
Organisme : Italian Ministry of Foreign Affairs and International Collaboration
Informations de copyright
© The Author(s) 2021. Published by Oxford University Press. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.
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