The association of in utero tobacco smoke exposure, quantified by serum cotinine, and Autism Spectrum Disorder.
Autism Spectrum Disorder
cotinine
pregnancy
smoking
tobacco smoking
Journal
Autism research : official journal of the International Society for Autism Research
ISSN: 1939-3806
Titre abrégé: Autism Res
Pays: United States
ID NLM: 101461858
Informations de publication
Date de publication:
09 2021
09 2021
Historique:
revised:
06
05
2021
received:
12
11
2020
accepted:
10
06
2021
pubmed:
25
6
2021
medline:
28
9
2021
entrez:
24
6
2021
Statut:
ppublish
Résumé
Previous studies on in utero exposure to maternal environmental tobacco smoke (ETS) or maternal active smoking and Autism Spectrum Disorder (ASD) have not been entirely consistent, and no studies have examined in utero cotinine concentrations as an exposure classification method. We measured cotinine in stored second trimester maternal serum for 498 ASD cases and 499 controls born in California in 2011-2012. We also obtained self-reported maternal cigarette smoking during and immediately prior to pregnancy, as well as covariate data, from birth records. Using unconditional logistic regression, we found no association between log10 cotinine concentrations and odds for developing ASD among children of non-smokers (aOR: 0.93 [95% CI: 0.69, 1.25] per ng/ml), which represents exposure to ETS, though there may be a possible interaction with race. We found no association between cotinine-defined smoking (≥3.08 ng/ml vs. <3.08 ng/ml) (adjusted odds ratio [aOR]: 0.73 (95% confidence interval [95% CI]: 0.35, 1.54)) or self-reported smoking (aOR: 1.64 [95% CI: 0.65, 4.16]) and ASD. In one of the few studies of ETS and the first with measured cotinine, our results indicate no overall relationship between in utero exposure to tobacco smoke from maternal ETS exposure or active smoking, and development of ASD. LAY SUMMARY: This study found that women who smoke or are exposed to tobacco smoke during pregnancy are not more likely to have children with Autism Spectrum Disorder (ASD). This is the first ASD study to measure a chemical in the mother's blood during pregnancy to identify exposure to tobacco smoke.
Substances chimiques
Tobacco Smoke Pollution
0
Cotinine
K5161X06LL
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.
Langues
eng
Sous-ensembles de citation
IM
Pagination
2017-2026Subventions
Organisme : NIH HHS
ID : K22 ES026235
Pays : United States
Organisme : NIH HHS
ID : R03 CA211820
Pays : United States
Organisme : NCI NIH HHS
ID : R03 CA211820
Pays : United States
Organisme : NIEHS NIH HHS
ID : K22 ES026235
Pays : United States
Informations de copyright
© 2021 International Society for Autism Research and Wiley Periodicals LLC.
Références
Agrawal, A., Scherrer, J. F., Grant, J. D., Sartor, C. E., Pergadia, M. L., Duncan, A. E., Madden, P. A. F., Haber, J. R., Jacob, T., Bucholz, K. K., & Xian, H. (2010). The effects of maternal smoking during pregnancy on offspring outcomes. Preventive Medicine, 50(1-2), 13-18.
Ashraf, M. W. (2012). Levels of heavy metals in popular cigarette brands and exposure to these metals via smoking. The Scientific World Journal, 2012. https://www.hindawi.com/journals/tswj/2012/729430/.
Banik, A., Kandilya, D., Ramya, S., Stünkel, W., Chong, Y. S., & Dheen, S. T. (2017). Maternal factors that induce epigenetic changes contribute to neurological disorders in offspring. Genes, 8(6), 150.
Benowitz, N. L. (1996). Cotinine as a biomarker of environmental tobacco smoke exposure. Epidemiologic Reviews, 18(2), 188-204.
Benowitz, N. L., Bernert, J. T., Caraballo, R. S., Holiday, D. B., & Wang, J. (2009). Optimal serum cotinine levels for distinguishing cigarette smokers and nonsmokers within different racial/ethnic groups in the United States between 1999 and 2004. American Journal of Epidemiology, 169(2), 236-248.
Bilder, D., Pinborough-Zimmerman, J., Miller, J., & McMahon, W. (2009). Prenatal, perinatal, and neonatal factors associated with autism spectrum disorders. Pediatrics, 123(5), 1293-1300.
Bölte, S., Girdler, S., & Marschik, P. B. (2019). The contribution of environmental exposure to the etiology of autism spectrum disorder. Cellular and Molecular Life Sciences, 76(7), 1275-1297.
Burstyn, I., Kapur, N., Shalapay, C., Bamforth, F., Wild, T. C., Liu, J., & LeGatt, D. (2009). Evaluation of the accuracy of self-reported smoking in pregnancy when the biomarker level in an active smoker is uncertain. Nicotine & Tobacco Research, 11(6), 670-678.
Burstyn, I., Sithole, F., & Zwaigenbaum, L. (2010). Autism spectrum disorders, maternal characteristics and obstetric complications among singletons born in Alberta, Canada. Chronic Diseases in Canada, 30(4), 125-134.
Caramaschi, D., Taylor, A. E., Richmond, R. C., Havdahl, K. A., Golding, J., Relton, C. L., Munafò, M. R., Smith, G. D., & Rai, D. (2018). Maternal smoking during pregnancy and autism: Using causal inference methods in a birth cohort study. Translational Psychiatry, 8(1), 1-10.
Croen, L. A., Grether, J. K., Hoogstrate, J., & Selvin, S. (2002). The changing prevalence of autism in California. Journal of Autism and Developmental Disorders, 32(3), 207-215.
Cunningham, G. C., & Tompkinson, D. G. (1999). Cost and effectiveness of the California triple marker prenatal screening program. Genetics in Medicine, 1(5), 199-206.
Dietz, P. M., Adams, M. M., Kendrick, J. S., & Mathis, M. P. (1998). Completeness of ascertainment of prenatal smoking using birth certificates and confidential questionnaires: Variations by maternal attributes and infant birth weight. American Journal of Epidemiology, 148(11), 1048-1054.
Dodds, L., Fell, D. B., Shea, S., Armson, B. A., Allen, A. C., & Bryson, S. (2011). The role of prenatal, obstetric and neonatal factors in the development of autism. Journal of Autism and Developmental Disorders, 41(7), 891-902.
Duan, G., Yao, M., Ma, Y., & Zhang, W. (2014). Perinatal and background risk factors for childhood autism in central China. Psychiatry Research, 220(1-2), 410-417.
Dwyer, J. B., McQuown, S. C., & Leslie, F. M. (2009). The dynamic effects of nicotine on the developing brain. Pharmacology & Therapeutics, 122(2), 125-139.
Gould, G. S., Havard, A., Lim, L. L., & Kumar, R. (2020). Exposure to tobacco, environmental tobacco smoke and nicotine in pregnancy: A pragmatic overview of reviews of maternal and child outcomes, effectiveness of interventions and barriers and facilitators to quitting. International Journal of Environmental Research and Public Health, 17(6), 2034.
Hiscock, R., Bauld, L., Amos, A., Fidler, J. A., & Munafò, M. (2012). Socioeconomic status and smoking: A review. Annals of the New York Academy of Sciences, 1248(1), 107-123.
Huizink, A. C., & Mulder, E. J. (2006). Maternal smoking, drinking or cannabis use during pregnancy and neurobehavioral and cognitive functioning in human offspring. Neuroscience & Biobehavioral Reviews, 30(1), 24-41.
Hultman, C. M., Sparén, P., & Cnattingius, S. (2002). Perinatal risk factors for infantile autism. Epidemiology, 13(4), 417-423.
Jiang, H., Liu, L., Sun, D., Yin, X., Chen, Z., Wu, C., & Chen, W. (2016). Interaction between passive smoking and folic acid supplement during pregnancy on autism spectrum disorder behaviors in children aged 3 years. Zhonghua liu xing bing xue za zhi= Zhonghua liuxingbingxue zazhi, 37(7), 940-944.
Jung, Y., Lee, A. M., McKee, S. A., & Picciotto, M. R. (2017). Maternal smoking and autism spectrum disorder: Meta-analysis with population smoking metrics as moderators. Scientific Reports, 7(1), 1-10.
Kalkbrenner, A. E., Braun, J. M., Durkin, M. S., Maenner, M. J., Cunniff, C., Lee, L.-C., Pettygrove, S., Nicholas, J. S., & Daniels, J. L. (2012). Maternal smoking during pregnancy and the prevalence of autism spectrum disorders, using data from the autism and developmental disabilities monitoring network. Environmental Health Perspectives, 120(7), 1042-1048.
Kalkbrenner, A. E., Meier, S. M., Madley-Dowd, P., Ladd-Acosta, C., Fallin, M. D., Parner, E., & Schendel, D. (2020). Familial confounding of the association between maternal smoking in pregnancy and autism spectrum disorder in offspring. Autism Research, 13(1), 134-144.
Kim, K. M., Lim, M. H., Kwon, H.-J., Yoo, S.-J., Kim, E.-J., Kim, J. W., Ha, M., & Paik, K. C. (2018). Associations between urinary cotinine and symptoms of attention deficit/hyperactivity disorder and autism spectrum disorder. Environmental Research, 166, 481-486.
Kolevzon, A., Gross, R., & Reichenberg, A. (2007). Prenatal and perinatal risk factors for autism: A review and integration of findings. Archives of Pediatrics & Adolescent Medicine, 161(4), 326-333.
Ladd-Acosta, C., Shu, C., Lee, B. K., Gidaya, N., Singer, A., Schieve, L. A., Schendel, D. E., Jones, N., Daniels, J. L., Windham, G. C., Newschaffer, C. J., Croen, L. A., Feinberg, A. P., & Fallin, M. D. (2016). Presence of an epigenetic signature of prenatal cigarette smoke exposure in childhood. Environmental Research, 144, 139-148.
Lee, B. K., Gardner, R. M., Dal, H., Svensson, A., Galanti, M. R., Rai, D., Dalman, C., & Magnusson, C. (2012). Brief report: Maternal smoking during pregnancy and autism spectrum disorders. Journal of Autism and Developmental Disorders, 42(9), 2000-2005.
Lei, G., Xi, Q. Q., Wu, J., Han, Y., Dai, W., Su, Y. Y., & Zhang, X. (2015). Association between prenatal environmental factors and child autism: A case control study in Tianjin, China. Biomedical and Environmental Sciences, 28(9), 642-650.
Liu, D., Zhan, J.-Y., & Shao, J. (2015). Environmental risk factors for autism spectrum disorders in children. Zhongguo dang dai er ke za zhi= Chinese journal of contemporary pediatrics, 17(11), 1147-1153.
Lyall, K., Croen, L., Daniels, J., Fallin, M. D., Ladd-Acosta, C., Lee, B. K., Park, B. Y., Snyder, N. W., Schendel, D., Volk, H., Windham, G. C., & Newschaffer, C. (2017). The changing epidemiology of autism spectrum disorders. Annual Review of Public Health, 38, 81-102.
Lyall, K., Windham, G. C., Snyder, N. W., Kuskovsky, R., Xu, P., Bostwick, A., Robinson, L., & Newschaffer, C. J. (2021). Association between midpregnancy polyunsaturated fatty acid levels and offspring autism spectrum disorder in a California population-based case-control study. American Journal of Epidemiology, 190(2), 265-276.
Maimburg, R. D., & Vaeth, M. (2006). Perinatal risk factors and infantile autism. Acta Psychiatrica Scandinavica, 114(4), 257-264.
Mandic-Maravic, V., Coric, V., Mitkovic-Voncina, M., Djordjevic, M., Savic-Radojevic, A., Ercegovac, M., Matic, M., Simic, T., Lecic-Tosevski, D., Toskovic, O., Pekmezovic, T., Pljesa-Ercegovac, M., & Pejovic-Milovancevic, M. (2019). Interaction of glutathione S-transferase polymorphisms and tobacco smoking during pregnancy in susceptibility to autism spectrum disorders. Scientific Reports, 9(1), 1-9.
Miguel, P. M., Pereira, L. O., Silveira, P. P., & Meaney, M. J. (2019). Early environmental influences on the development of children's brain structure and function. Developmental Medicine & Child Neurology, 61(10), 1127-1133.
Mrozek-Budzyn, D., Majewska, R., & Kieltyka, A. (2013). Prenatal, perinatal and neonatal risk factors for autism-study in Poland. Central European Journal of Medicine, 8(4), 424-430.
Ng, M., Freeman, M. K., Fleming, T. D., Robinson, M., Dwyer-Lindgren, L., Thomson, B., Wollum, A., Sanman, E., Wulf, S., Lopez, A. D., Murray, C. J. L., & Gakidou, E. (2014). Smoking prevalence and cigarette consumption in 187 countries, 1980-2012. JAMA, 311(2), 183-192.
Nilsen, R. M., Surén, P., Gunnes, N., Alsaker, E. R., Bresnahan, M., Hirtz, D., Hornig, M., Lie, K. K., Lipkin, W. I., Reichborn-Kjennerud, T., Roth, C., Schjølberg, S., Smith, G. D., Susser, E., Vollset, S. E., Øyen, A.-S., Magnus, P., & Stoltenberg, C. (2013). Analysis of self-selection bias in a population-based cohort study of autism spectrum disorders. Paediatric and Perinatal Epidemiology, 27(6), 553-563.
Ornoy, A., Weinstein-Fudim, L., & Ergaz, Z. (2015). Prenatal factors associated with autism spectrum disorder (ASD). Reproductive Toxicology, 56, 155-169.
Pauly, J. R., & Slotkin, T. A. (2008). Maternal tobacco smoking, nicotine replacement and neurobehavioural development. Acta Paediatrica, 97(10), 1331-1337.
Qin, Y.-Y., Jian, B., Wu, C., Jiang, C.-Z., Kang, Y., Zhou, J.-X., Yang, F., & Liang, Y. (2018). A comparison of blood metal levels in autism spectrum disorder and unaffected children in Shenzhen of China and factors involved in bioaccumulation of metals. Environmental Science and Pollution Research, 25(18), 17950-17956.
Saunders, A., Woodland, J., & Gander, S. (2019). A comparison of prenatal exposures in children with and without a diagnosis of autism spectrum disorder. Cureus, 11(7), e5223.
Scherer, G., Conze, C., Tricker, A., & Adlkofer, F. (1992). Uptake of tobacco smoke constituents on exposure to environmental tobacco smoke (ETS). The Clinical Investigator, 70(3-4), 352-367.
Shea, A. K., & Steiner, M. (2008). Cigarette smoking during pregnancy. Nicotine & Tobacco Research, 10(2), 267-278.
Signorello, L. B., Cai, Q., Tarone, R. E., McLaughlin, J. K., & Blot, W. J. (2009). Racial differences in serum cotinine levels of smokers. Disease Markers, 27(5), 187-192.
Slotkin, T. A. (2008). If nicotine is a developmental neurotoxicant in animal studies, dare we recommend nicotine replacement therapy in pregnant women and adolescents? Neurotoxicology and Teratology, 30(1), 1-19.
Toledo-Rodriguez, M., Lotfipour, S., Leonard, G., Perron, M., Richer, L., Veillette, S., Pausova, Z., & Paus, T. (2010). Maternal smoking during pregnancy is associated with epigenetic modifications of the brain-derived neurotrophic factor-6 exon in adolescent offspring. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics, 153(7), 1350-1354.
Totsika, V., Hastings, R. P., Emerson, E., Lancaster, G. A., & Berridge, D. M. (2011). A population-based investigation of behavioural and emotional problems and maternal mental health: Associations with autism spectrum disorder and intellectual disability. Journal of Child Psychology and Psychiatry, 52(1), 91-99.
Tran, P. L., Lehti, V., Lampi, K. M., Helenius, H., Suominen, A., Gissler, M., Brown, A. S., & Sourander, A. (2013). Smoking during pregnancy and risk of autism spectrum disorder in a Finnish National Birth Cohort. Paediatric and Perinatal Epidemiology, 27(3), 266-274.
Vinikoor, L. C., Messer, L. C., Laraia, B. A., & Kaufman, J. S. (2010). Reliability of variables on the North Carolina birth certificate: A comparison with directly queried values from a cohort study. Paediatric and Perinatal Epidemiology, 24(1), 102-112.
Vorstman, J. A., Parr, J. R., Moreno-De-Luca, D., Anney, R. J., Nurnberger, J. I., Jr., & Hallmayer, J. F. (2017). Autism genetics: Opportunities and challenges for clinical translation. Nature Reviews Genetics, 18(6), 362.
Wang, C., Geng, H., Liu, W., & Zhang, G. (2017). Prenatal, perinatal, and postnatal factors associated with autism: A meta-analysis. Medicine, 96(18), e6696.
Windham, G. C., Anderson, M. C., Croen, L. A., Smith, K. S., Collins, J., & Grether, J. K. (2011). Birth prevalence of autism spectrum disorders in the San Francisco Bay area by demographic and ascertainment source characteristics. Journal of Autism and Developmental Disorders, 41(10), 1362-1372.
Zablotsky, B., Black, L. I., & Blumberg, S. J. (2017). Estimated prevalence of children with diagnosed developmental disabilities in the United States, 2014-2016. NCHS Data Brief, no 291. Hyattsville, MD: National Center for Health Statistics. https://www.cdc.gov/nchs/products/databriefs/db291.htm?fbclid=IwAR0MwhWDgawPU
Zhang, X., Lv, C.-C., Tian, J., Miao, R.-J., Xi, W., Hertz-Picciotto, I., & Qi, L. (2010). Prenatal and perinatal risk factors for autism in China. Journal of Autism and Developmental Disorders, 40(11), 1311-1321.