Genetic Basis and Therapies for Vascular Anomalies.

Angiogenesis Inhibitors / adverse effects Animals Blood Vessels / abnormalities Genetic Predisposition to Disease Humans Molecular Targeted Therapy Mutation Neovascularization, Physiologic / drug effects Phenotype Protein Kinase Inhibitors / adverse effects Signal Transduction Vascular Malformations / drug therapy
endothelium mutation precision medicine sirolimus thalidomide

Journal

Circulation research
ISSN: 1524-4571
Titre abrégé: Circ Res
Pays: United States
ID NLM: 0047103

Informations de publication

Date de publication:
25 06 2021
Historique:
entrez: 24 6 2021
pubmed: 25 6 2021
medline: 30 11 2021
Statut: ppublish

Résumé

Vascular and lymphatic malformations represent a challenge for clinicians. The identification of inherited and somatic mutations in important signaling pathways, including the PI3K (phosphoinositide 3-kinase)/AKT (protein kinase B)/mTOR (mammalian target of rapamycin), RAS (rat sarcoma)/RAF (rapidly accelerated fibrosarcoma)/MEK (mitogen-activated protein kinase kinase)/ERK (extracellular signal-regulated kinases), HGF (hepatocyte growth factor)/c-Met (hepatocyte growth factor receptor), and VEGF (vascular endothelial growth factor) A/VEGFR (vascular endothelial growth factor receptor) 2 cascades has led to the evaluation of tailored strategies with preexisting cancer drugs that interfere with these signaling pathways. The era of theranostics has started for the treatment of vascular anomalies. Registration: URL: https://www.clinicaltrialsregister.eu; Unique identifier: 2015-001703-32.

Identifiants

DOI: 10.1161/CIRCRESAHA.121.318145 PMID: 34166070
pubmed: 34166070
doi: 10.1161/CIRCRESAHA.121.318145
doi:

Substances chimiques

Angiogenesis Inhibitors 0
Protein Kinase Inhibitors 0

Banques de données

EudraCT
['2015-001703-32']

Types de publication

Journal Article Research Support, Non-U.S. Gov't Review

Langues

eng

Sous-ensembles de citation

IM

Pagination

155-173

Auteurs

Angela Queisser (A)

Human Molecular Genetics, de Duve Institute, University of Louvain, Brussels, Belgium (A.Q., L.M.B., M.V.), University of Louvain, Brussels, Belgium (M.V.).

Emmanuel Seront (E)

Centre for Vascular Anomalies, Division of Plastic Surgery, Cliniques Universitaires Saint-Luc Brussels, Belgium (E.S., L.M.B., M.V.).
Institut Roi Albert II, Department of Medical Oncology, Cliniques Universitaires Saint-Luc, Brussels, Belgium (E.S.).
VASCERN VASCA European Reference Centre Cliniques Universitaires Saint-Luc, Brussels, Belgium (E.S., L.M.B., M.V.).

Laurence M Boon (LM)

Human Molecular Genetics, de Duve Institute, University of Louvain, Brussels, Belgium (A.Q., L.M.B., M.V.), University of Louvain, Brussels, Belgium (M.V.).
Centre for Vascular Anomalies, Division of Plastic Surgery, Cliniques Universitaires Saint-Luc Brussels, Belgium (E.S., L.M.B., M.V.).
VASCERN VASCA European Reference Centre Cliniques Universitaires Saint-Luc, Brussels, Belgium (E.S., L.M.B., M.V.).

Miikka Vikkula (M)

Human Molecular Genetics, de Duve Institute, University of Louvain, Brussels, Belgium (A.Q., L.M.B., M.V.), University of Louvain, Brussels, Belgium (M.V.).
Centre for Vascular Anomalies, Division of Plastic Surgery, Cliniques Universitaires Saint-Luc Brussels, Belgium (E.S., L.M.B., M.V.).
University of Louvain, Brussels, Belgium (M.V.).
University of Louvain, Brussels, Belgium (M.V.).
Walloon Excellence in Life Sciences and Biotechnology (WELBIO), University of Louvain, Brussels, Belgium (M.V.).
VASCERN VASCA European Reference Centre Cliniques Universitaires Saint-Luc, Brussels, Belgium (E.S., L.M.B., M.V.).

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Classifications MeSH

questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Utilisations thérapeutiques › Antinéoplasiques › Inhibiteurs de l'angiogenèse › Genetic Basis and Therapies for Vascular Anomalies.
questionsmedicales.fr › Eucaryotes › Animaux › Genetic Basis and Therapies for Vascular Anomalies.
questionsmedicales.fr › Système cardiovasculaire › Vaisseaux sanguins › Genetic Basis and Therapies for Vascular Anomalies.
questionsmedicales.fr › Phénomènes génétiques › Génotype › Prédisposition génétique à une maladie › Genetic Basis and Therapies for Vascular Anomalies.
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Genetic Basis and Therapies for Vascular Anomalies.
questionsmedicales.fr › Thérapeutique › Traitement médicamenteux › Thérapie moléculaire ciblée › Genetic Basis and Therapies for Vascular Anomalies.
questionsmedicales.fr › Phénomènes génétiques › Variation génétique › Mutation › Genetic Basis and Therapies for Vascular Anomalies.
questionsmedicales.fr › Phénomènes physiologiques respiratoires et circulatoires › Phénomènes physiologiques cardiovasculaires › Néovascularisation physiologique › Genetic Basis and Therapies for Vascular Anomalies.
questionsmedicales.fr › Phénomènes génétiques › Phénotype › Genetic Basis and Therapies for Vascular Anomalies.
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Mécanismes moléculaires de l'action pharmacologique › Antienzymes › Inhibiteurs de protéines kinases › Genetic Basis and Therapies for Vascular Anomalies.
questionsmedicales.fr › Phénomènes physiologiques cellulaires › Transduction du signal › Genetic Basis and Therapies for Vascular Anomalies.
questionsmedicales.fr › Malformations et maladies congénitales, héréditaires et néonatales › Malformations › Malformations cardiovasculaires › Anomalies vasculaires › Genetic Basis and Therapies for Vascular Anomalies.