Follicular lymphoma triggers phenotypic and functional remodeling of the human lymphoid stromal cell landscape.
B-Lymphocytes
/ immunology
Cells, Cultured
Chemokine CCL19
/ metabolism
Chemokine CCL21
/ metabolism
Dendritic Cells
/ immunology
Humans
Integrin alpha1
/ metabolism
Lymphoma, Follicular
/ immunology
Palatine Tonsil
/ cytology
Signal Transduction
/ immunology
Stromal Cells
/ cytology
Transforming Growth Factor beta1
/ genetics
Tumor Necrosis Factor-alpha
/ genetics
B cell lymphoma
cancer-associated fibroblasts
chemokines
fibroblastic reticular cells
follicular dendritic cells
tumor microenvironment
Journal
Immunity
ISSN: 1097-4180
Titre abrégé: Immunity
Pays: United States
ID NLM: 9432918
Informations de publication
Date de publication:
10 08 2021
10 08 2021
Historique:
received:
25
09
2020
revised:
18
03
2021
accepted:
27
05
2021
pubmed:
25
6
2021
medline:
24
9
2021
entrez:
24
6
2021
Statut:
ppublish
Résumé
Lymphoid stromal cells (LSCs) are essential organizers of immune responses. We analyzed tonsillar tissue by combining flow cytometry, in situ imaging, RNA sequencing, and functional assays, defining three distinct human LSC subsets. The integrin CD49a designated perivascular stromal cells exhibiting features of local committed LSC precursors and segregated cytokine and chemokine-producing fibroblastic reticular cells (FRCs) supporting B and T cell survival. The follicular dendritic cell transcriptional profile reflected active responses to B cell and non-B cell stimuli. We therefore examined the effect of B cell stimuli on LSCs in follicular lymphoma (FL). FL B cells interacted primarily with CD49a
Identifiants
pubmed: 34166622
pii: S1074-7613(21)00225-9
doi: 10.1016/j.immuni.2021.05.019
pii:
doi:
Substances chimiques
CCL19 protein, human
0
CCL21 protein, human
0
Chemokine CCL19
0
Chemokine CCL21
0
Integrin alpha1
0
TGFB1 protein, human
0
TNF protein, human
0
Transforming Growth Factor beta1
0
Tumor Necrosis Factor-alpha
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1788-1806.e7Commentaires et corrections
Type : CommentIn
Type : ErratumIn
Informations de copyright
Copyright © 2021 Elsevier Inc. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of interests The authors declare no competing interests.