Effects of chiropractic spinal manipulation on laser-evoked pain and brain activity.
Electroencephalography
Hypoalgesia
Nociceptive fibers
Spinal manipulation
Journal
The journal of physiological sciences : JPS
ISSN: 1880-6562
Titre abrégé: J Physiol Sci
Pays: Japan
ID NLM: 101262417
Informations de publication
Date de publication:
24 Jun 2021
24 Jun 2021
Historique:
received:
24
02
2021
accepted:
15
06
2021
entrez:
25
6
2021
pubmed:
26
6
2021
medline:
25
12
2021
Statut:
epublish
Résumé
The aim of this study was to examine the mechanisms underlying hypoalgesia induced by spinal manipulation (SM). Eighty-two healthy volunteers were assigned to one of the four intervention groups: no intervention, SM at T4 (homosegmental to pain), SM at T8 (heterosegmental to pain) or light mechanical stimulus at T4 (placebo). Eighty laser stimuli were applied on back skin at T4 to evoke pain and brain activity related to Aδ- and C-fibers activation. The intervention was performed after 40 stimuli. Laser pain was decreased by SM at T4 (p = 0.028) but not T8 (p = 0.13), compared with placebo. However, brain activity related to Aδ-fibers activation was not significantly modulated (all p > 0.05), while C-fiber activity could not be measured reliably. This indicates that SM produces segmental hypoalgesia through inhibition of nociceptive processes that are independent of Aδ fibers. It remains to be clarified whether the effect is mediated by the inhibition of C-fiber activity.
Identifiants
pubmed: 34167458
doi: 10.1186/s12576-021-00804-2
pii: 10.1186/s12576-021-00804-2
pmc: PMC10717656
doi:
Types de publication
Journal Article
Randomized Controlled Trial
Langues
eng
Sous-ensembles de citation
IM
Pagination
20Subventions
Organisme : Natural Science and Engineering Research Council of Canada
ID : 06659
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