Longitudinal Bone Loss Occurs at the Radius in CKD.
bone mineral density
chronic kidney disease–mineral bone disorders
fracture
osteoporosis
parathyroid hormone
Journal
Kidney international reports
ISSN: 2468-0249
Titre abrégé: Kidney Int Rep
Pays: United States
ID NLM: 101684752
Informations de publication
Date de publication:
Jun 2021
Jun 2021
Historique:
received:
07
03
2021
accepted:
08
03
2021
entrez:
25
6
2021
pubmed:
26
6
2021
medline:
26
6
2021
Statut:
epublish
Résumé
Chronic kidney disease (CKD) exposes to an increased incidence of fragility fractures. International guidelines recommend performing bone mineral density (BMD) if the results will impact treatment decisions. It remains unknown where bone loss occurs and what would preclude the longitudinal loss in patients with CKD. Here, we aimed to investigate factors influencing BMD and to analyze the longitudinal BMD changes. In the NephroTest cohort, we measured BMD at the femoral neck, total hip, lumbar spine, and proximal radius, together with circulating biomarkers and standardized measured glomerular filtration rate (mGFR) by At baseline, cross-sectional analysis showed a significantly lower BMD at femoral neck and total hip and a significant higher serum parathyroid hormone (PTH) along with CKD stages. Baseline age, gender, tobacco, low body mass index (BMI), and high PTH levels were significantly associated with low BMD. Longitudinal analysis during the mean 4.3 years revealed a significant bone loss at the radius only. BMD changes at the femoral neck were associated with BMI, but not CKD stages or basal PTH levels. CKD is associated with low BMD and high PTH in the cross-sectional analysis. Longitudinal bone loss occurred at the proximal radius after 4.3 years.
Identifiants
pubmed: 34169193
doi: 10.1016/j.ekir.2021.03.874
pii: S2468-0249(21)01020-2
pmc: PMC8207310
doi:
Types de publication
Journal Article
Langues
eng
Pagination
1525-1536Investigateurs
Emmanuel Letavernier
(E)
Pierre Ronco
(P)
Hafedh Fessi
(H)
Eric Daugas
(E)
Caroline du Halgouet
(C)
Renaud de La Faille
(R)
Christian d'Auzac
(C)
Gerard Maruani
(G)
Marion Vallet
(M)
Cédric Gauci
(C)
Jean Philippe Haymann
(JP)
Eric Thervet
(E)
Jean-Jacques Boffa
(JJ)
François Vrtovsnik
(F)
Marc Froissart
(M)
Bénédicte Stengel
(B)
Laurence Nicolet-Barousse
(L)
Mélanie Roland
(M)
Christian Jacquot
(C)
Informations de copyright
© 2021 International Society of Nephrology. Published by Elsevier Inc.
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