Enhanced MCP-1 Release in Early Autosomal Dominant Polycystic Kidney Disease.
ADPKD
chemokine
distal tubule
inflammation
pediatric nephrology
proximal tubule
Journal
Kidney international reports
ISSN: 2468-0249
Titre abrégé: Kidney Int Rep
Pays: United States
ID NLM: 101684752
Informations de publication
Date de publication:
Jun 2021
Jun 2021
Historique:
received:
01
01
2021
revised:
07
03
2021
accepted:
22
03
2021
entrez:
25
6
2021
pubmed:
26
6
2021
medline:
26
6
2021
Statut:
epublish
Résumé
Autosomal dominant polycystic kidney disease (ADPKD) causes kidney failure typically in adulthood, but the disease starts In a cross-sectional study, plasma copeptin, urinary EGF, and urinary MCP-1 were evaluated in a pediatric ADPKD cohort and compared with age-, sex-, and body mass index (BMI)-matched healthy controls. MCP-1 was studied in mouse collecting duct cells, human proximal tubular cells, and fetal kidney tissue. Fifty-three genotyped ADPKD patients and 53 controls were included. The mean (SD) age was 10.4 (5.9) versus 10.5 (6.1) years ( An increase in tubular MCP-1 secretion is an early event in ADPKD. MCP-1 is an early disease severity marker and a potential treatment target.
Identifiants
pubmed: 34169210
doi: 10.1016/j.ekir.2021.03.893
pii: S2468-0249(21)01041-X
pmc: PMC8207325
doi:
Types de publication
Journal Article
Langues
eng
Pagination
1687-1698Informations de copyright
© 2021 International Society of Nephrology. Published by Elsevier Inc.
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