Sex and gender differences in COVID-19: More to be learned!

COVID-19 Disparities Gender Outcomes Sex

Journal

American heart journal plus : cardiology research and practice
ISSN: 2666-6022
Titre abrégé: Am Heart J Plus
Pays: United States
ID NLM: 101779333

Informations de publication

Date de publication:
Mar 2021
Historique:
received: 01 03 2021
revised: 25 03 2021
accepted: 06 04 2021
entrez: 25 6 2021
pubmed: 26 6 2021
medline: 26 6 2021
Statut: ppublish

Résumé

The COVID-19 pandemic has affected millions of patients across the globe. Multiple studies, national and international governmental data have shown important sex and gender differences in the incidence and outcomes of patients with COVID-19. These differences are not only attributed to the differences in age and comorbid conditions but likely a combination of factors, including hormonal differences, immune response, inflammatory markers and behavioral attitudes, among others. In this review, we discuss the studies addressing sex- and gender-specific differences in COVID-19 infections with a focus on the potential pathophysiological mechanisms of these differences.

Identifiants

pubmed: 34169297
doi: 10.1016/j.ahjo.2021.100011
pii: S2666-6022(21)00009-4
pmc: PMC8045422
doi:

Types de publication

Journal Article Review

Langues

eng

Pagination

100011

Informations de copyright

© 2021 The Author(s).

Déclaration de conflit d'intérêts

The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.

Références

Clin Infect Dis. 2020 Dec 15;71(12):3188-3195
pubmed: 32634830
Commun Biol. 2020 Jul 8;3(1):374
pubmed: 32641750
Nat Commun. 2020 Dec 9;11(1):6317
pubmed: 33298944
BMJ. 2020 Sep 1;370:m3320
pubmed: 32873575
J Stroke Cerebrovasc Dis. 2020 Nov;29(11):105314
pubmed: 32951959
JACC Case Rep. 2020 Jul 15;2(9):1407-1410
pubmed: 32373791
Mayo Clin Proc. 2020 Aug;95(8):1613-1620
pubmed: 32753136
N Engl J Med. 2020 Nov 5;383(19):1813-1826
pubmed: 32445440
Mayo Clin Proc. 2020 Oct;95(10):2189-2203
pubmed: 33012349
BMJ Open. 2020 Oct 6;10(10):e040129
pubmed: 33028563
Lancet Infect Dis. 2020 Aug;20(8):904-905
pubmed: 32738239
Lancet Glob Health. 2021 Jan;9(1):e14-e15
pubmed: 33160453
Proc Natl Acad Sci U S A. 2020 Nov 3;117(44):27285-27291
pubmed: 33060298
PLoS One. 2021 Jan 13;16(1):e0245556
pubmed: 33439908
Science. 2021 Jan 22;371(6527):347-348
pubmed: 33479140
Andrology. 2013 Nov;1(6):919-28
pubmed: 24124163
Ann Intern Med. 2020 Sep 1;173(5):385-386
pubmed: 32384135
JAMA. 2020 Oct 6;324(13):1330-1341
pubmed: 32876694
Aging (Albany NY). 2020 Oct 13;12(19):18833-18843
pubmed: 33051404
PLoS Pathog. 2020 Apr 28;16(4):e1008520
pubmed: 32343745
PLoS One. 2020 Oct 6;15(10):e0237297
pubmed: 33022004
SN Compr Clin Med. 2020 Aug 9;:1-4
pubmed: 32838184
CMAJ. 2020 Sep 8;192(36):E1041-E1045
pubmed: 32900766
Circ Cardiovasc Interv. 2020 Mar;13(3):e009034
pubmed: 32151160
N Engl J Med. 2021 Feb 4;384(5):403-416
pubmed: 33378609
JAMA. 2020 Oct 6;324(13):1274
pubmed: 33021653
Eur Respir J. 2020 May 14;55(5):
pubmed: 32217650
J Racial Ethn Health Disparities. 2021 Jan 19;:
pubmed: 33469866
N Engl J Med. 2020 Dec 31;383(27):2603-2615
pubmed: 33301246
Biol Sex Differ. 2020 Oct 16;11(1):57
pubmed: 33066823
Front Public Health. 2020 Apr 29;8:152
pubmed: 32411652

Auteurs

Lina Ya'qoub (L)

Department of Cardiology, Ochsner-Louisiana State University, Shreveport, LA, USA.

Islam Y Elgendy (IY)

Department of Medicine, Weill Cornell Medicine-Qatar, Doha, Qatar.

Carl J Pepine (CJ)

Division of Cardiovascular Medicine, University of Florida, Gainesville, FL, USA.

Classifications MeSH