Comparison of isoflurane and propofol sedation in critically ill COVID-19 patients-a retrospective chart review.
AnaConDa
COVID-19
Critical care
ECMO
Inhaled sedation
Isoflurane
Journal
Journal of anesthesia
ISSN: 1438-8359
Titre abrégé: J Anesth
Pays: Japan
ID NLM: 8905667
Informations de publication
Date de publication:
10 2021
10 2021
Historique:
received:
03
05
2021
accepted:
06
06
2021
pubmed:
26
6
2021
medline:
29
9
2021
entrez:
25
6
2021
Statut:
ppublish
Résumé
In this retrospective study, we compared inhaled sedation with isoflurane to intravenous propofol in invasively ventilated COVID-19 patients with ARDS (Acute Respiratory Distress Syndrome). Charts of all 20 patients with COVID-19 ARDS admitted to the ICU of a German University Hospital during the first wave of the pandemic between 22/03/2020 and 21/04/2020 were reviewed. Among screened 333 days, isoflurane was used in 97 days, while in 187 days, propofol was used for 12 h or more. The effect and dose of these two sedatives were compared. Mixed sedation days were excluded. Patients' age (median [interquartile range]) was 64 (60-68) years. They were invasively ventilated for 36 [21-50] days. End-tidal isoflurane concentrations were high (0.96 ± 0.41 Vol %); multiple linear regression yielded the ratio (isoflurane infusion rate)/(minute ventilation) as the single best predictor. Infusion rates were decreased under ECMO (3.5 ± 1.4 versus 7.1 ± 3.2 ml∙h Isoflurane provided sufficient sedation with less NMBAs, less polypharmacy and lower opioid doses compared to propofol. High doses of both drugs were needed in severely ill COVID-19 patients.
Identifiants
pubmed: 34169362
doi: 10.1007/s00540-021-02960-6
pii: 10.1007/s00540-021-02960-6
pmc: PMC8225486
doi:
Substances chimiques
Hypnotics and Sedatives
0
Isoflurane
CYS9AKD70P
Propofol
YI7VU623SF
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
625-632Informations de copyright
© 2021. The Author(s).
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