Histological analysis of fat grafting with platelet-rich plasma for diabetic foot ulcers-A randomised controlled trial.
adipose-derived stem cells
diabetic foot ulcers
fat grafting
histology
platelet-rich plasma
Journal
International wound journal
ISSN: 1742-481X
Titre abrégé: Int Wound J
Pays: England
ID NLM: 101230907
Informations de publication
Date de publication:
Feb 2022
Feb 2022
Historique:
revised:
26
05
2021
received:
22
02
2021
accepted:
31
05
2021
pubmed:
26
6
2021
medline:
19
1
2022
entrez:
25
6
2021
Statut:
ppublish
Résumé
Diabetic foot ulcers are often unresponsive to conventional therapy and are a leading cause of amputation. Animal studies have shown stem cells and growth factors can accelerate wound healing. Adipose-derived stem cells are found in fat grafts and mixing them with platelet-rich plasma (PRP) may improve graft survival. This study aimed to establish the histological changes when diabetic foot ulcers are treated with fat grafts and PRP. A three-armed RCT was undertaken of 18 diabetic foot ulcer patients: fat grafting; fat grafting with PRP; and routine podiatry care. Biopsies were obtained at week 0, 1, and 4, and underwent quantitative histology/immunohistochemistry (H&E, CD31, and Ki67). Treatment with fat and PRP increased mean microvessel density at 1 week to 1645 (SD 96) microvessels/mm
Identifiants
pubmed: 34169656
doi: 10.1111/iwj.13640
pmc: PMC8762540
doi:
Banques de données
ClinicalTrials.gov
['NCT03085550']
Types de publication
Journal Article
Randomized Controlled Trial
Langues
eng
Sous-ensembles de citation
IM
Pagination
389-398Informations de copyright
© 2021 The Authors. International Wound Journal published by Medicalhelplines.com Inc (3M) and John Wiley & Sons Ltd.
Références
Arthroscopy. 2018 Feb;34(2):581-591
pubmed: 29100775
Ann Dermatol. 2011 May;23(2):150-5
pubmed: 21747612
Plast Reconstr Surg. 2012 May;129(5):1081-1092
pubmed: 22261562
Int Wound J. 2020 Dec;17(6):1578-1594
pubmed: 32633854
Exp Cell Res. 2012 Jan 1;318(1):8-15
pubmed: 22020322
Cytotherapy. 2003;5(5):362-9
pubmed: 14578098
Diabetologia. 2008 May;51(5):747-55
pubmed: 18297261
Arch Dermatol Res. 2016 Sep;308(7):511-20
pubmed: 27394438
J Plast Reconstr Aesthet Surg. 2010 Dec;63(12):e818-22
pubmed: 20708988
J Plast Reconstr Aesthet Surg. 2019 Apr;72(4):669-675
pubmed: 30658950
Stem Cell Res Ther. 2017 Feb 28;8(1):45
pubmed: 28241882
Platelets. 2019;30(6):773-792
pubmed: 30252623
Plast Reconstr Surg. 2009 Sep;124(3):804-815
pubmed: 19730299
Int Wound J. 2022 Feb;19(2):389-398
pubmed: 34169656
Cell Transplant. 2011;20(2):205-16
pubmed: 20719083
Breast Cancer Res Treat. 1995;36(2):169-80
pubmed: 8534865
Biomed Res Int. 2016;2016:6591717
pubmed: 27672658
Adipocyte. 2021 Dec;10(1):80-90
pubmed: 33525977
J Dermatol Sci. 2007 Oct;48(1):15-24
pubmed: 17643966
Trends Biotechnol. 2006 Apr;24(4):150-4
pubmed: 16488036
Diabetes. 2015 Aug;64(8):2723-34
pubmed: 25795216
Ann Plast Surg. 2009 Mar;62(3):317-21
pubmed: 19240532
Am J Surg Pathol. 2012 Dec;36(12):1761-70
pubmed: 23026928
Gynecol Oncol. 2003 May;89(2):251-8
pubmed: 12713988
Lancet. 2005 Nov 12;366(9498):1736-43
pubmed: 16291068
Exp Clin Transplant. 2018 Mar;16 Suppl 1(Suppl 1):95-100
pubmed: 29528001
Aesthetic Plast Surg. 2011 Aug;35(4):480-6
pubmed: 21184066
J Tissue Eng. 2011;2011:158105
pubmed: 21772956
Stem Cells. 2007 Oct;25(10):2648-59
pubmed: 17615264
Plast Reconstr Surg. 2008 Nov;122(5):1352-1360
pubmed: 18971718
Sci Rep. 2017 Dec 4;7(1):16878
pubmed: 29203879
Aesthet Surg J. 2021 Apr 12;41(5):NP241
pubmed: 33150383
Dermatol Surg. 2011 May;37(5):619-25
pubmed: 21492303
Stem Cell Res Ther. 2016 Oct 22;7(1):155
pubmed: 27770835
Chin Med J (Engl). 2015 May 5;128(9):1245-51
pubmed: 25947410
Wound Repair Regen. 2013 Jul-Aug;21(4):545-53
pubmed: 23627689
Wound Repair Regen. 2008 Sep-Oct;16(5):585-601
pubmed: 19128254
Diabet Med. 2016 Nov;33(11):1493-1498
pubmed: 26666583
Ann Plast Surg. 2010 Jul;65(1):101-6
pubmed: 20548232
Ann Med Surg (Lond). 2017 Jun 27;20:49-60
pubmed: 28702187
Methods Enzymol. 2013;533:225-33
pubmed: 24182927
Stem Cells Dev. 2008 Aug;17(4):669-80
pubmed: 18788931
Acta Cir Bras. 2009 Jul-Aug;24(4):276-81
pubmed: 19705027
Wound Repair Regen. 2007 Jul-Aug;15(4):505-10
pubmed: 17650094
Orthop J Sports Med. 2017 Jan 03;5(1):2325967116675272
pubmed: 28210651
Diabetes Care. 1990 May;13(5):513-21
pubmed: 2351029
Stem Cells. 2009 Jan;27(1):250-8
pubmed: 18818439
Ann Plast Surg. 2012 Dec;69(6):656-62
pubmed: 23154338
J Plast Reconstr Aesthet Surg. 2018 May;71(5):681-690
pubmed: 29477267
Tissue Eng Part B Rev. 2014 Aug;20(4):267-76
pubmed: 24004354
Exp Mol Pathol. 2003 Jun;74(3):244-55
pubmed: 12782011
Arterioscler Thromb Vasc Biol. 2009 Apr;29(4):503-10
pubmed: 19201690
J Burn Care Rehabil. 2005 Jul-Aug;26(4):293-305
pubmed: 16006836
Laryngoscope. 2007 Jan;117(1):96-100
pubmed: 17202937