Glial-derived neurotrophic factor in human airway smooth muscle.
Ret receptor
airway
asthma
calcium
neurotrophin
Journal
Journal of cellular physiology
ISSN: 1097-4652
Titre abrégé: J Cell Physiol
Pays: United States
ID NLM: 0050222
Informations de publication
Date de publication:
12 2021
12 2021
Historique:
revised:
18
05
2021
received:
04
01
2021
accepted:
09
06
2021
pubmed:
26
6
2021
medline:
13
1
2022
entrez:
25
6
2021
Statut:
ppublish
Résumé
Airway smooth muscle (ASM) cells modulate the local airway milieu via production of inflammatory mediators and growth factors including classical neurotrophins, such as brain-derived neurotrophic factor (BDNF). The glial cell-derived neurotrophic factor (GDNF) family of ligands (GFLs) are nonclassical neurotrophins and their role in the airway is barely understood. The major GFLs, GDNF and Neurturin (NRTN) bind to GDNF family receptor (GFR) α1 and α2 respectively that pair with Ret receptor to accomplish signaling. In this study, we found GDNF is expressed in human lung and increased in adult asthma, while human ASM expresses GDNF and its receptors. Accordingly, we used human ASM cells to test the hypothesis that ASM expression and autocrine signaling by GFLs regulate [Ca
Identifiants
pubmed: 34170009
doi: 10.1002/jcp.30489
pmc: PMC8671171
mid: NIHMS1716492
doi:
Substances chimiques
GDNF protein, human
0
Glial Cell Line-Derived Neurotrophic Factor
0
Glial Cell Line-Derived Neurotrophic Factor Receptors
0
NRTN protein, human
0
Neurturin
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
8184-8196Subventions
Organisme : NHLBI NIH HHS
ID : R01 HL088029
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL142061
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL146705
Pays : United States
Informations de copyright
© 2021 Wiley Periodicals LLC.
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