Epstein-Barr virus (EBV) hyperimmune globulin isolated from donors with high gp350 antibody titers protect humanized mice from challenge with EBV.
Epstein-barr virus
Glycoprotein 350
Herpesvirus
Hyperimmune globulin
Journal
Virology
ISSN: 1096-0341
Titre abrégé: Virology
Pays: United States
ID NLM: 0110674
Informations de publication
Date de publication:
09 2021
09 2021
Historique:
received:
30
04
2021
revised:
15
06
2021
accepted:
17
06
2021
pubmed:
26
6
2021
medline:
24
12
2021
entrez:
25
6
2021
Statut:
ppublish
Résumé
Primary infection with Epstein-Barr virus (EBV) is associated with post-transplant lymphoproliferative disease and severe disease in patients with X-linked lymphoproliferative disease; no therapies are approved to prevent EBV infection in these patients. Hyperimmune globulin has been used to prevent some virus infections in immunocompromised persons. Here, we identified plasma donors with high titers of EBV gp350 and EBV B cell neutralizing antibodies. Pooled IgG isolated from these donors was compared to intravenous immunoglobulin (IVIG) for its ability to reduce viral load in the blood in humanized mice challenged with EBV. Mice that received EBV hyperimmune globulin had significantly reduced EBV DNA copy numbers compared to animals that received saline control; however, while animals that received EBV hyperimmune globulin had lower EBV DNA copies than those that received IVIG, the difference was not significant. Thus, while EBV hyperimmune globulin reduced viral load compared to IVIG, the effect was modest.
Identifiants
pubmed: 34171765
pii: S0042-6822(21)00136-7
doi: 10.1016/j.virol.2021.06.006
pmc: PMC8803478
mid: NIHMS1771030
pii:
doi:
Substances chimiques
Antibodies, Neutralizing
0
Antibodies, Viral
0
EBV-associated membrane antigen, Epstein-Barr virus
0
Viral Matrix Proteins
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
80-86Subventions
Organisme : CCR NIH HHS
ID : HHSN261200800001C
Pays : United States
Organisme : NCI NIH HHS
ID : HHSN261200800001E
Pays : United States
Organisme : NIAID NIH HHS
ID : T32 AI125186
Pays : United States
Organisme : Intramural NIH HHS
ID : Z01 AI000978
Pays : United States
Commentaires et corrections
Type : ErratumIn
Informations de copyright
Copyright © 2021. Published by Elsevier Inc.
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