Systemic regulation of mitochondria by germline proteostasis prevents protein aggregation in the soma of
Journal
Science advances
ISSN: 2375-2548
Titre abrégé: Sci Adv
Pays: United States
ID NLM: 101653440
Informations de publication
Date de publication:
Jun 2021
Jun 2021
Historique:
received:
04
01
2021
accepted:
12
05
2021
entrez:
26
6
2021
pubmed:
27
6
2021
medline:
27
6
2021
Statut:
epublish
Résumé
Protein aggregation causes intracellular changes in neurons, which elicit signals to modulate proteostasis in the periphery. Beyond the nervous system, a fundamental question is whether other organs also communicate their proteostasis status to distal tissues. Here, we examine whether proteostasis of the germ line influences somatic tissues. To this end, we induce aggregation of germline-specific PGL-1 protein in germline stem cells of
Identifiants
pubmed: 34172445
pii: 7/26/eabg3012
doi: 10.1126/sciadv.abg3012
pmc: PMC8232903
pii:
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : European Research Council
ID : 677427
Pays : International
Informations de copyright
Copyright © 2021 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works. Distributed under a Creative Commons Attribution NonCommercial License 4.0 (CC BY-NC).
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