Effectiveness of combined vaginal progesterone and cervical cerclage in preventing preterm birth: a systematic review and meta-analysis protocol.
fetal medicine
maternal medicine
obstetrics
prenatal diagnosis
Journal
BMJ open
ISSN: 2044-6055
Titre abrégé: BMJ Open
Pays: England
ID NLM: 101552874
Informations de publication
Date de publication:
25 06 2021
25 06 2021
Historique:
entrez:
26
6
2021
pubmed:
27
6
2021
medline:
1
7
2021
Statut:
epublish
Résumé
Preterm birth (PTB) is the leading cause of death in children under 5 years. Preventive therapies targeted towards women with risk factors such as a prior PTB or a short cervix reduce the rate of PTB. Cervical cerclage, vaginal progesterone and a combination of the two have been used with no consensus as to whether combined treatment is more effective than any single treatment alone. The objective of this review is to determine the efficacy of combined treatment compared with cerclage alone and combined treatment compared with progesterone alone. Studies will be sourced from the electronic databases Medline (Ovid), EMBASE (Ovid), PsycINFO (Ovid), Scopus, CINAHL (EBSCOhost) and Cochrane Library (Wiley) and reference lists. We will not exclude any papers due to publication date. Randomised control trials (RCTs), non-RCTs and cohort studies assessing single therapy (either progesterone or cerclage) versus combined therapy in women with a singleton pregnancy will be included. Two independent reviewers will conduct study screening (at abstract and full-text level), data extraction and risk of bias assessment with disagreements resolved by an experienced researcher. Random or fixed effects models will be used depending on data heterogeneity and data will be presented as risk ratio for dichotomous data or mean difference for continuous data with a CI of 95% used for all outcomes. Not applicable due to nature of the study type. CRD42020195975.
Identifiants
pubmed: 34172552
pii: bmjopen-2021-050086
doi: 10.1136/bmjopen-2021-050086
pmc: PMC8237739
doi:
Substances chimiques
Progesterone
4G7DS2Q64Y
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
e050086Informations de copyright
© Author(s) (or their employer(s)) 2021. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.
Déclaration de conflit d'intérêts
Competing interests: JP is supported by the Hunter New England Health Clinical and Health Research Fellowship.
Références
Sci Rep. 2020 Jan 21;10(1):855
pubmed: 31965004
Acta Obstet Gynecol Scand. 1977;56(3):247-53
pubmed: 560099
Lancet. 2012 Jun 9;379(9832):2162-72
pubmed: 22682464
BMC Med Res Methodol. 2005 Apr 20;5:13
pubmed: 15840177
J Obstet Gynaecol Res. 2016 Dec;42(12):1666-1672
pubmed: 27641755
Br J Obstet Gynaecol. 1993 Jun;100(6):516-23
pubmed: 8334085
BMJ. 2016 Oct 12;355:i4919
pubmed: 27733354
Geburtshilfe Frauenheilkd. 2019 Aug;79(8):844-853
pubmed: 31423019
Syst Rev. 2015 Jan 01;4:1
pubmed: 25554246
BMJ. 2019 Aug 28;366:l4898
pubmed: 31462531
Obstet Gynecol Int. 2013;2013:528158
pubmed: 23606847
Bull World Health Organ. 2010 Jan;88(1):31-8
pubmed: 20428351
Am J Obstet Gynecol. 1963 Mar 15;85:792-805
pubmed: 13969672
Hum Reprod. 2000 Jun;15 Suppl 1:159-65
pubmed: 10928427
J Obstet Gynaecol Br Emp. 1957 Jun;64(3):346-50
pubmed: 13449654
Int J Evid Based Healthc. 2015 Sep;13(3):196-207
pubmed: 26355603
BJOG. 2003 Apr;110 Suppl 20:8-16
pubmed: 12763105
Lancet. 2008 Jan 5;371(9606):75-84
pubmed: 18177778
J Matern Fetal Neonatal Med. 2006 Dec;19(12):763-72
pubmed: 17190686
Maturitas. 1995 Apr;21(3):251-7
pubmed: 7616875
Obstet Gynecol. 2011 Mar;117(3):663-671
pubmed: 21446209
Lancet Glob Health. 2019 Jan;7(1):e37-e46
pubmed: 30389451
BMC Med Res Methodol. 2014 Dec 19;14:135
pubmed: 25524443
J Matern Fetal Neonatal Med. 2021 Aug;34(15):2473-2480
pubmed: 31558069
J Obstet Gynaecol Can. 2017 Dec;39(12):1192-1202
pubmed: 29197486
Am J Obstet Gynecol. 2018 Feb;218(2):161-180
pubmed: 29157866