Temporal trends of SARS-CoV-2 seroprevalence during the first wave of the COVID-19 epidemic in Kenya.


Journal

Nature communications
ISSN: 2041-1723
Titre abrégé: Nat Commun
Pays: England
ID NLM: 101528555

Informations de publication

Date de publication:
25 06 2021
Historique:
received: 19 02 2021
accepted: 25 05 2021
entrez: 26 6 2021
pubmed: 27 6 2021
medline: 20 7 2021
Statut: epublish

Résumé

Observed SARS-CoV-2 infections and deaths are low in tropical Africa raising questions about the extent of transmission. We measured SARS-CoV-2 IgG by ELISA in 9,922 blood donors across Kenya and adjusted for sampling bias and test performance. By 1st September 2020, 577 COVID-19 deaths were observed nationwide and seroprevalence was 9.1% (95%CI 7.6-10.8%). Seroprevalence in Nairobi was 22.7% (18.0-27.7%). Although most people remained susceptible, SARS-CoV-2 had spread widely in Kenya with apparently low associated mortality.

Identifiants

pubmed: 34172732
doi: 10.1038/s41467-021-24062-3
pii: 10.1038/s41467-021-24062-3
pmc: PMC8233334
mid: EMS129551
doi:

Substances chimiques

Antibodies, Viral 0
Immunoglobulin G 0
Spike Glycoprotein, Coronavirus 0
spike protein, SARS-CoV-2 0

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

3966

Subventions

Organisme : Wellcome Trust (Wellcome)
ID : 220991/Z/20/Z, 203077/Z/16/Z
Organisme : Wellcome Trust
ID : 214320
Pays : United Kingdom
Organisme : Wellcome Trust
ID : 218647
Pays : United Kingdom
Organisme : Medical Research Council
ID : MR/R006083/1
Pays : United Kingdom
Organisme : Medical Research Council
ID : MR/S005293/1
Pays : United Kingdom
Organisme : Wellcome Trust
ID : 203077
Pays : United Kingdom
Organisme : Wellcome Trust
ID : 107568
Pays : United Kingdom
Organisme : Wellcome Trust
ID : 222574
Pays : United Kingdom
Organisme : EPA
ID : EP-C-15-003
Pays : United States
Organisme : Wellcome Trust
Pays : United Kingdom
Organisme : Medical Research Council
ID : MR/R010161/1
Pays : United Kingdom
Organisme : Wellcome Trust
ID : 220991
Pays : United Kingdom

Références

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Auteurs

Ifedayo M O Adetifa (IMO)

KEMRI-Wellcome Trust Research Programme, Kilifi, Kenya. IAdetifa@kemri-wellcome.org.
Department of Infectious Diseases Epidemiology, London School of Hygiene and Tropical Medicine, Keppel Street, London, United Kingdom. IAdetifa@kemri-wellcome.org.

Sophie Uyoga (S)

KEMRI-Wellcome Trust Research Programme, Kilifi, Kenya. SUyoga@kemri-wellcome.org.

John N Gitonga (JN)

KEMRI-Wellcome Trust Research Programme, Kilifi, Kenya.

Daisy Mugo (D)

KEMRI-Wellcome Trust Research Programme, Kilifi, Kenya.

Mark Otiende (M)

KEMRI-Wellcome Trust Research Programme, Kilifi, Kenya.

James Nyagwange (J)

KEMRI-Wellcome Trust Research Programme, Kilifi, Kenya.

Henry K Karanja (HK)

KEMRI-Wellcome Trust Research Programme, Kilifi, Kenya.

James Tuju (J)

KEMRI-Wellcome Trust Research Programme, Kilifi, Kenya.

Perpetual Wanjiku (P)

KEMRI-Wellcome Trust Research Programme, Kilifi, Kenya.

Rashid Aman (R)

Ministry of Health, Government of Kenya, Nairobi, Kenya.

Mercy Mwangangi (M)

Ministry of Health, Government of Kenya, Nairobi, Kenya.

Patrick Amoth (P)

Ministry of Health, Government of Kenya, Nairobi, Kenya.

Kadondi Kasera (K)

Ministry of Health, Government of Kenya, Nairobi, Kenya.

Wangari Ng'ang'a (W)

Presidential Policy & Strategy Unit, The Presidency, Government of Kenya, Nairobi, Kenya.

Charles Rombo (C)

Kenya National Blood Transfusion Services, Ministry of Health, Nairobi, Kenya.

Christine Yegon (C)

Kenya National Blood Transfusion Services, Ministry of Health, Nairobi, Kenya.

Khamisi Kithi (K)

Kenya National Blood Transfusion Services, Ministry of Health, Nairobi, Kenya.

Elizabeth Odhiambo (E)

Kenya National Blood Transfusion Services, Ministry of Health, Nairobi, Kenya.

Thomas Rotich (T)

Kenya National Blood Transfusion Services, Ministry of Health, Nairobi, Kenya.

Irene Orgut (I)

Kenya National Blood Transfusion Services, Ministry of Health, Nairobi, Kenya.

Sammy Kihara (S)

Kenya National Blood Transfusion Services, Ministry of Health, Nairobi, Kenya.

Christian Bottomley (C)

Department of Infectious Diseases Epidemiology, London School of Hygiene and Tropical Medicine, Keppel Street, London, United Kingdom.

Eunice W Kagucia (EW)

KEMRI-Wellcome Trust Research Programme, Kilifi, Kenya.

Katherine E Gallagher (KE)

KEMRI-Wellcome Trust Research Programme, Kilifi, Kenya.
Department of Infectious Diseases Epidemiology, London School of Hygiene and Tropical Medicine, Keppel Street, London, United Kingdom.

Anthony Etyang (A)

KEMRI-Wellcome Trust Research Programme, Kilifi, Kenya.

Shirine Voller (S)

KEMRI-Wellcome Trust Research Programme, Kilifi, Kenya.
Department of Infectious Diseases Epidemiology, London School of Hygiene and Tropical Medicine, Keppel Street, London, United Kingdom.

Teresa Lambe (T)

Nuffield Department of Medicine, Oxford University, Oxford, United Kingdom.

Daniel Wright (D)

Nuffield Department of Medicine, Oxford University, Oxford, United Kingdom.

Edwine Barasa (E)

KEMRI-Wellcome Trust Research Programme, Kilifi, Kenya.

Benjamin Tsofa (B)

KEMRI-Wellcome Trust Research Programme, Kilifi, Kenya.

Philip Bejon (P)

KEMRI-Wellcome Trust Research Programme, Kilifi, Kenya.
Nuffield Department of Medicine, Oxford University, Oxford, United Kingdom.

Lynette I Ochola-Oyier (LI)

KEMRI-Wellcome Trust Research Programme, Kilifi, Kenya.

Ambrose Agweyu (A)

KEMRI-Wellcome Trust Research Programme, Kilifi, Kenya.

J Anthony G Scott (JAG)

KEMRI-Wellcome Trust Research Programme, Kilifi, Kenya.
Department of Infectious Diseases Epidemiology, London School of Hygiene and Tropical Medicine, Keppel Street, London, United Kingdom.
Nuffield Department of Medicine, Oxford University, Oxford, United Kingdom.

George M Warimwe (GM)

KEMRI-Wellcome Trust Research Programme, Kilifi, Kenya.
Nuffield Department of Medicine, Oxford University, Oxford, United Kingdom.

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