High dietary potassium causes ubiquitin-dependent degradation of the kidney sodium-chloride cotransporter.
Animals
Disease Models, Animal
HSP70 Heat-Shock Proteins
/ metabolism
Hypertension
/ drug therapy
Kidney Tubules, Distal
/ metabolism
Male
Mice
Mice, Inbred C57BL
Phosphorylation
Potassium, Dietary
/ pharmacology
Proteolysis
Signal Transduction
Solute Carrier Family 12, Member 3
/ genetics
Ubiquitination
aldosterone
hypertension
kidney
posttranslational modification (PTM)
ubiquitylation (ubiquitination)
Journal
The Journal of biological chemistry
ISSN: 1083-351X
Titre abrégé: J Biol Chem
Pays: United States
ID NLM: 2985121R
Informations de publication
Date de publication:
08 2021
08 2021
Historique:
received:
18
12
2020
revised:
10
06
2021
accepted:
22
06
2021
pubmed:
27
6
2021
medline:
15
12
2021
entrez:
26
6
2021
Statut:
ppublish
Résumé
The thiazide-sensitive sodium-chloride cotransporter (NCC) in the renal distal convoluted tubule (DCT) plays a critical role in regulating blood pressure (BP) and K
Identifiants
pubmed: 34174287
pii: S0021-9258(21)00715-8
doi: 10.1016/j.jbc.2021.100915
pmc: PMC8318901
pii:
doi:
Substances chimiques
HSP70 Heat-Shock Proteins
0
Potassium, Dietary
0
Solute Carrier Family 12, Member 3
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
100915Informations de copyright
Copyright © 2021 The Authors. Published by Elsevier Inc. All rights reserved.
Déclaration de conflit d'intérêts
Conflicts of interest The authors declare that they have no conflicts of interest with the contents of this article.