Same salience, different consequences: Disturbed inter-network connectivity during a social oddball paradigm in major depressive disorder.
Default mode network
Depression
Functional connectivity
Oddball paradigm
Salience network
Target detection
Journal
NeuroImage. Clinical
ISSN: 2213-1582
Titre abrégé: Neuroimage Clin
Pays: Netherlands
ID NLM: 101597070
Informations de publication
Date de publication:
2021
2021
Historique:
received:
13
12
2020
revised:
28
05
2021
accepted:
12
06
2021
pubmed:
27
6
2021
medline:
14
9
2021
entrez:
26
6
2021
Statut:
ppublish
Résumé
So far findings on emotional face processing among depressed individuals reveal an inconsistent image, with only some studies supporting a mood-congruent bias in salience processing. Thereby, many results are based on the processing of sad emotions and mostly focused on resting-state connectivity analysis. The present study aimed to target this misbalance by implementing a social oddball paradigm, with a special focus on the amygdala, the ACC, the insula and subdivisions of insula and ACC. Twenty-seven depressed patients and twenty-seven non-depressed controls took part in a fMRI event-related social oddball paradigm based on smiling facial expressions as target stimuli embedded in a stream of neutral facial expressions. FMRI activation and functional connectivity analysis were calculated for the pre-defined ROIs of the salience network (SN), with a special focus on twelve insular subdivisions and six ACC subdivisions. For both groups the social oddball paradigm triggered similar BOLD responses within the pre-defined ROIs, while the quality of functional connectivity showed pronounced alterations from the salience network to the ventral attention- and default mode network (DMN). On a first level of target detection, smiling faces are equally processed and trigger similar bold responses in structures of the salience network. On a second level of inter-network communication the brain of depressed participants tends to be pre-formed for self-referential processing and rumination instead of fast goal directed behavior and socio-emotional cognitive processing.
Sections du résumé
BACKGROUND
So far findings on emotional face processing among depressed individuals reveal an inconsistent image, with only some studies supporting a mood-congruent bias in salience processing. Thereby, many results are based on the processing of sad emotions and mostly focused on resting-state connectivity analysis. The present study aimed to target this misbalance by implementing a social oddball paradigm, with a special focus on the amygdala, the ACC, the insula and subdivisions of insula and ACC.
METHODS
Twenty-seven depressed patients and twenty-seven non-depressed controls took part in a fMRI event-related social oddball paradigm based on smiling facial expressions as target stimuli embedded in a stream of neutral facial expressions. FMRI activation and functional connectivity analysis were calculated for the pre-defined ROIs of the salience network (SN), with a special focus on twelve insular subdivisions and six ACC subdivisions.
RESULTS
For both groups the social oddball paradigm triggered similar BOLD responses within the pre-defined ROIs, while the quality of functional connectivity showed pronounced alterations from the salience network to the ventral attention- and default mode network (DMN).
CONCLUSION
On a first level of target detection, smiling faces are equally processed and trigger similar bold responses in structures of the salience network. On a second level of inter-network communication the brain of depressed participants tends to be pre-formed for self-referential processing and rumination instead of fast goal directed behavior and socio-emotional cognitive processing.
Identifiants
pubmed: 34174690
pii: S2213-1582(21)00175-3
doi: 10.1016/j.nicl.2021.102731
pmc: PMC8234357
pii:
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
102731Informations de copyright
Copyright © 2021. Published by Elsevier Inc.