Potential Relevance of B-cell Maturation Pathways in Defining the Cell(s) of Origin for Chronic Lymphocytic Leukemia.

Chronic lymphocytic leukemia (CLL) is a common, incurable disease of undefined cause. Notably, the normal cell equivalents of CLL cells remain elusive, and it is possible that the disease emanates from several normal B-cell subsets. This article reviews the literature relating to this issue, focusing on recent findings, in particular made through epigenetic analyses that strongly support the disease developing from a normal Ag-experienced and memory cell-like B lymphocyte. It also reports the known pathways whereby normal B lymphocytes mature after antigenic challenge and proposes that this information is relevant in defining the cells of origin of this disease.

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Copyright © 2021 The Authors. Published by Elsevier Inc. All rights reserved.

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Acknowledgments The authors thank The Nash Family Foundation, the Karches Foundation, The Marks Foundation, and the Jean Walton Fund for Leukemia, Lymphoma and Myeloma Research for their support.