The Significance of B-cell Receptor Stereotypy in Chronic Lymphocytic Leukemia: Biological and Clinical Implications.

Humans Immunoglobulin Variable Region / genetics Leukemia, Lymphocytic, Chronic, B-Cell / genetics Receptors, Antigen, B-Cell / genetics Somatic Hypermutation, Immunoglobulin
B-cell receptor Chronic lymphocytic leukemia IGHV genes Immunogenetics Immunoglobulin Somatic hypermutation Stereotypy

Journal

Hematology/oncology clinics of North America
ISSN: 1558-1977
Titre abrégé: Hematol Oncol Clin North Am
Pays: United States
ID NLM: 8709473

Informations de publication

Date de publication:
08 2021
Historique:
entrez: 27 6 2021
pubmed: 28 6 2021
medline: 5 3 2022
Statut: ppublish

Résumé

The finding that (quasi)identical, stereotyped B-cell receptor (BcR) immunoglobulins IGs) are expressed in a significant fraction of chronic lymphocytic leukemia (CLL) highlighted the importance of antigen selection in disease pathogenesis. Subsets of patients sharing the same stereotyped BcR IG display consistent biological features and, at least for certain subsets, clinical presentation and outcome, including the response to particular treatment. On these grounds, BcR IG stereotypy emerges as a useful tool for dissecting the pronounced heterogeneity of CLL toward refining risk stratification and therapeutic management aligned with the principles of precision medicine.

Identifiants

DOI: 10.1016/j.hoc.2021.03.003 PMID: 34174980
pubmed: 34174980
pii: S0889-8588(21)00035-6
doi: 10.1016/j.hoc.2021.03.003
pii:
doi:

Substances chimiques

Immunoglobulin Variable Region 0
Receptors, Antigen, B-Cell 0

Types de publication

Journal Article Research Support, Non-U.S. Gov't Review

Langues

eng

Sous-ensembles de citation

IM

Pagination

687-702

Informations de copyright

Copyright © 2021 Elsevier Inc. All rights reserved.

Déclaration de conflit d'intérêts

Disclosure K. Stamatopoulos has received honoraria and research support from AbbVie, Janssen, AstraZeneca, and Gilead. Conflict of Interest The authors declare no conflict of interest.

Auteurs

Elisavet Vlachonikola (E)

Institute of Applied Biosciences, Centre for Research and Technology Hellas, 6th km Charilaou - Thermis, 57001 Thermi, Thessaloniki, Greece; Department of Genetics and Molecular Biology, Faculty of Biology, Aristotle University of Thessaloniki, Thessaloniki 54124, Greece.

Electra Sofou (E)

Institute of Applied Biosciences, Centre for Research and Technology Hellas, 6th km Charilaou - Thermis, 57001 Thermi, Thessaloniki, Greece; Laboratory of Biological Chemistry, School of Medicine, Aristotle University of Thessaloniki, Thessaloniki 54124, Greece.

Anastasia Chatzidimitriou (A)

Institute of Applied Biosciences, Centre for Research and Technology Hellas, 6th km Charilaou - Thermis, 57001 Thermi, Thessaloniki, Greece; Department of Immunology, Genetics and Pathology, Uppsala University, Uppsala 75236, Sweden.

Kostas Stamatopoulos (K)

Institute of Applied Biosciences, Centre for Research and Technology Hellas, 6th km Charilaou - Thermis, 57001 Thermi, Thessaloniki, Greece; Department of Immunology, Genetics and Pathology, Uppsala University, Uppsala 75236, Sweden. Electronic address: kostas.stamatopoulos@certh.gr.

Andreas Agathangelidis (A)

Institute of Applied Biosciences, Centre for Research and Technology Hellas, 6th km Charilaou - Thermis, 57001 Thermi, Thessaloniki, Greece.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › The Significance of B-cell Receptor Stereotypy...
questionsmedicales.fr › Phénomènes chimiques › Phénomènes biochimiques › Région variable d'immunoglobuline › The Significance of B-cell Receptor Stereotypy...
questionsmedicales.fr › États, signes et symptômes pathologiques › Processus pathologiques › Caractéristiques de la maladie › Maladie chronique › Leucémie chronique lymphocytaire à cellules B › The Significance of B-cell Receptor Stereotypy...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Récepteurs de surface cellulaire › Récepteurs immunologiques › Récepteurs aux antigènes › Récepteurs pour l'antigène des lymphocytes B › The Significance of B-cell Receptor Stereotypy...
questionsmedicales.fr › Phénomènes du système immunitaire › Phénomènes immunogénétiques › Hypermutation somatique des gènes des immunoglobulines › The Significance of B-cell Receptor Stereotypy...