Prodrug-based nano-delivery strategy to improve the antitumor ability of carboplatin
Animals
Carboplatin
/ administration & dosage
Cell Line, Tumor
Cell Survival
Chemistry, Pharmaceutical
Drug Carriers
/ chemistry
Drug Liberation
Female
Mice
Mice, Nude
Micelles
Nanoparticles
/ chemistry
Particle Size
Polyethylene Glycols
/ chemistry
Prodrugs
/ administration & dosage
Random Allocation
Solubility
Carboplatin
anti-tumor effect
nano-delivery system
prodrug
self-assembled micelles
Journal
Drug delivery
ISSN: 1521-0464
Titre abrégé: Drug Deliv
Pays: England
ID NLM: 9417471
Informations de publication
Date de publication:
Dec 2021
Dec 2021
Historique:
entrez:
28
6
2021
pubmed:
29
6
2021
medline:
20
11
2021
Statut:
ppublish
Résumé
Chemotherapy plays a major role in the treatment of cancer, but it still has great limitations in anti-tumor effect. Carboplatin (CAR) is the first-line drug in the treatment of non-small cell lung cancer, but the therapeutic effect is demonstrated weak. Therefore, we modified CAR with hexadecyl chain and polyethylene glycol, so as to realize its liposolubility and PEGylation. The synthesized amphiphilic CAR prodrugs could self-assemble into polymer micelles in water with an average particle size about 11.8 nm and low critical micelles concentration (0.0538 mg·mL
Identifiants
pubmed: 34176381
doi: 10.1080/10717544.2021.1938754
pmc: PMC8238065
doi:
Substances chimiques
Drug Carriers
0
Micelles
0
Prodrugs
0
Polyethylene Glycols
3WJQ0SDW1A
Carboplatin
BG3F62OND5
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
1272-1280Références
Acta Pharmacol Sin. 2017 Jun;38(6):782-797
pubmed: 28504252
Int J Pharm. 2020 Jun 15;583:119351
pubmed: 32339634
J Am Chem Soc. 2014 Jun 18;136(24):8790-8
pubmed: 24902769
Chem Res Toxicol. 2015 Dec 21;28(12):2250-2
pubmed: 26544157
Int J Mol Sci. 2019 Nov 12;20(22):
pubmed: 31726728
Proc Natl Acad Sci U S A. 2011 Feb 1;108(5):1850-5
pubmed: 21233423
Chem Biol. 2004 Apr;11(4):557-64
pubmed: 15123250
Int J Nanomedicine. 2019 Nov 07;14:8805-8818
pubmed: 31806973
Chem Soc Rev. 2019 Apr 1;48(7):2053-2108
pubmed: 30259015
ACS Macro Lett. 2020 Nov 17;9(11):1687-1692
pubmed: 35617071
Chem Commun (Camb). 2010 Nov 28;46(44):8424-6
pubmed: 20936244
Chem Res Toxicol. 2010 Nov 15;23(11):1653-5
pubmed: 21028869
J Pharm Biomed Anal. 2019 Nov 30;176:112786
pubmed: 31398506
ACS Nano. 2017 May 23;11(5):4582-4592
pubmed: 28426929
Drug Deliv. 2016 Sep;23(7):2144-2153
pubmed: 25544603
ACS Nano. 2014 May 27;8(5):4205-20
pubmed: 24730557
Expert Rev Anticancer Ther. 2016 Jun;16(6):653-60
pubmed: 27010977
J Exp Nanosci. 2016 Dec 12;11(sup1):S1-S11
pubmed: 27366201
Bioinorg Chem Appl. 2018 Oct 1;2018:8276139
pubmed: 30402082
Wiley Interdiscip Rev Nanomed Nanobiotechnol. 2017 Mar;9(2):
pubmed: 27094725
Redox Biol. 2019 Jul;25:101084
pubmed: 30612957
ACS Biomater Sci Eng. 2019 Aug 12;5(8):4013-4022
pubmed: 33117884
Nano Lett. 2017 Sep 13;17(9):5429-5436
pubmed: 28753017
Mol Pharm. 2016 Nov 7;13(11):3665-3675
pubmed: 27712076
J Control Release. 2015 Feb 28;200:138-57
pubmed: 25545217
Langmuir. 2019 Jan 29;35(4):848-861
pubmed: 29923405
ACS Nano. 2014 Oct 28;8(10):10998-1006
pubmed: 25300001
Semin Cell Dev Biol. 2018 Aug;80:50-64
pubmed: 28587975
J Am Chem Soc. 2007 Jul 11;129(27):8438-9
pubmed: 17569542
J Am Chem Soc. 2008 Sep 3;130(35):11584-5
pubmed: 18686947
Curr Opin Chem Biol. 2013 Apr;17(2):175-88
pubmed: 23395452
Acta Biomater. 2021 Apr 1;124:179-190
pubmed: 33524560
Mol Pharm. 2017 Aug 7;14(8):2697-2710
pubmed: 28704056
ACS Omega. 2017 Oct 31;2(10):6349-6360
pubmed: 29104951
Pulm Pharmacol Ther. 2020 Dec;65:102002
pubmed: 33596473
Biomaterials. 2020 Feb;232:119751
pubmed: 31918218
Adv Drug Deliv Rev. 2012 Aug;64(11):993-1004
pubmed: 22289471
ACS Appl Mater Interfaces. 2020 Jul 15;12(28):31112-31123
pubmed: 32544316
Mol Pharm. 2020 Jun 1;17(6):1945-1953
pubmed: 32320251
Bioconjug Chem. 2016 Oct 19;27(10):2225-2238
pubmed: 27547843
J Drug Target. 2016 Sep;24(8):671-8
pubmed: 26878159
ACS Appl Mater Interfaces. 2019 May 29;11(21):18914-18922
pubmed: 31055911
ACS Appl Mater Interfaces. 2013 Aug 28;5(16):7995-8001
pubmed: 23869943
Oncol Rep. 2017 Aug;38(2):611-624
pubmed: 28627697
Nano Lett. 2019 Aug 14;19(8):5356-5365
pubmed: 31286779
ACS Biomater Sci Eng. 2016 Dec 12;2(12):2347-2354
pubmed: 33465883
Biomacromolecules. 2016 Sep 12;17(9):2992-9
pubmed: 27548375
Expert Opin Pharmacother. 2019 Jan;20(1):95-102
pubmed: 30439289
Chem Commun (Camb). 2021 Mar 2;57(18):2305-2308
pubmed: 33533351
J Inorg Biochem. 2012 Dec;117:220-9
pubmed: 22877926
ACS Appl Mater Interfaces. 2021 Feb 10;13(5):6053-6068
pubmed: 33525873
Nano Lett. 2017 Feb 8;17(2):928-937
pubmed: 28139118
ACS Appl Mater Interfaces. 2019 May 8;11(18):16391-16401
pubmed: 31002492
Angew Chem Int Ed Engl. 2018 Mar 12;57(12):3008-3010
pubmed: 29450950
ACS Appl Mater Interfaces. 2014 Apr 9;6(7):5212-20
pubmed: 24606837
J Colloid Interface Sci. 2021 Apr;587:358-366
pubmed: 33360905
Nano Lett. 2016 Sep 14;16(9):5401-8
pubmed: 27490088
Dalton Trans. 2020 Apr 28;49(16):5192-5204
pubmed: 32236281
ACS Appl Mater Interfaces. 2013 Jun 12;5(11):4632-9
pubmed: 23633522
ACS Appl Mater Interfaces. 2016 Jun 1;8(21):13332-40
pubmed: 27164222
J Med Chem. 2020 Nov 25;63(22):13397-13412
pubmed: 32813515
ACS Biomater Sci Eng. 2019 May 13;5(5):2307-2315
pubmed: 33405781