Voxel-Based Morphometry of Cerebellar Lobules in Essential Tremor.
cerebellum
essential tremor
lobule volume
structural MRI
voxel-based morphometry
Journal
Frontiers in aging neuroscience
ISSN: 1663-4365
Titre abrégé: Front Aging Neurosci
Pays: Switzerland
ID NLM: 101525824
Informations de publication
Date de publication:
2021
2021
Historique:
received:
14
02
2021
accepted:
03
05
2021
entrez:
28
6
2021
pubmed:
29
6
2021
medline:
29
6
2021
Statut:
epublish
Résumé
The extent of neurodegeneration underlying essential tremor (ET) remains a matter of debate. Despite various extents of cerebellar atrophy on structural magnetic resonance imaging (MRI), previous studies have shown substantial heterogeneity and included a limited number of patients. Novel automated pipelines allow detailed segmentation of cerebellar lobules based on structural MRI. To compare the volumes of cerebellar lobules in ET patients with those in healthy controls (HCs) using an automated segmentation pipeline. Structural MRI scans of ET patients eligible for deep brain stimulation ( Total brain tissue volumes did not differ between the ET and HC groups. ET patients demonstrated reduced volumes of lobules I-II, left Crus II, left VIIB, and an increased volume of right X when compared with the HC group. A large cohort of ET patients demonstrated subtle signs of decreased cerebellar lobule volumes. These findings oppose the hypothesis of localized atrophy in cerebellar motor areas in ET, but not the possibility of cerebellar pathophysiology in ET. Prospective investigations using alternative neuroimaging modalities may further elucidate the pathophysiology of ET and provide insights into diagnostic and therapeutic approaches.
Sections du résumé
BACKGROUND
BACKGROUND
The extent of neurodegeneration underlying essential tremor (ET) remains a matter of debate. Despite various extents of cerebellar atrophy on structural magnetic resonance imaging (MRI), previous studies have shown substantial heterogeneity and included a limited number of patients. Novel automated pipelines allow detailed segmentation of cerebellar lobules based on structural MRI.
OBJECTIVE
OBJECTIVE
To compare the volumes of cerebellar lobules in ET patients with those in healthy controls (HCs) using an automated segmentation pipeline.
METHODS
METHODS
Structural MRI scans of ET patients eligible for deep brain stimulation (
RESULTS
RESULTS
Total brain tissue volumes did not differ between the ET and HC groups. ET patients demonstrated reduced volumes of lobules I-II, left Crus II, left VIIB, and an increased volume of right X when compared with the HC group.
CONCLUSION
CONCLUSIONS
A large cohort of ET patients demonstrated subtle signs of decreased cerebellar lobule volumes. These findings oppose the hypothesis of localized atrophy in cerebellar motor areas in ET, but not the possibility of cerebellar pathophysiology in ET. Prospective investigations using alternative neuroimaging modalities may further elucidate the pathophysiology of ET and provide insights into diagnostic and therapeutic approaches.
Identifiants
pubmed: 34177554
doi: 10.3389/fnagi.2021.667854
pmc: PMC8222624
doi:
Types de publication
Journal Article
Langues
eng
Pagination
667854Informations de copyright
Copyright © 2021 Ågren, Awad, Blomstedt and Fytagoridis.
Déclaration de conflit d'intérêts
PB is a consultant for Abbott, Medtronic, and Boston Scientific. He is a shareholder in Mithridaticum AB. The remaining authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
Références
Neuroimage. 2017 Feb 15;147:916-924
pubmed: 27833012
J Neurosci Methods. 2016 May 1;264:47-56
pubmed: 26945974
Cerebellum. 2016 Apr;15(2):174-81
pubmed: 26062905
J Neuroimaging. 2012 Jul;22(3):275-8
pubmed: 21447032
N Engl J Med. 2016 Aug 25;375(8):730-9
pubmed: 27557301
Tremor Other Hyperkinet Mov (N Y). 2014 Jul 22;4:252
pubmed: 25120943
Mov Disord. 2010 Dec 15;25(16):2884-7
pubmed: 20836089
Neuroimage. 2020 Apr 1;209:116511
pubmed: 31901420
Brain. 2018 Jul 1;141(7):1981-1997
pubmed: 29939198
Neurology. 2019 Jan 1;92(1):e30-e39
pubmed: 30504432
Front Neuroinform. 2016 Jul 27;10:30
pubmed: 27512372
Neurodegener Dis Manag. 2012 Jun;2(3):259-268
pubmed: 23105950
Neurology. 2006 Jan 10;66(1):69-74
pubmed: 16401849
Cerebellum Ataxias. 2017 Jul 3;4:10
pubmed: 28680651
Neuroimage Clin. 2017 Jun 02;16:468-476
pubmed: 28913163
Neurology. 2007 Nov 20;69(21):1982-9
pubmed: 18025392
J Neurol. 2015 Mar;262(3):719-28
pubmed: 25572161
Neurology. 2006 Oct 24;67(8):1452-6
pubmed: 17060572
Eur J Neurol. 2007 Oct;14(10):1138-46
pubmed: 17708753
AJNR Am J Neuroradiol. 2017 Aug;38(8):1501-1509
pubmed: 28642263
Neurology. 2018 Aug 7;91(6):e543-e550
pubmed: 29970404
Brain. 2015 Oct;138(Pt 10):2934-47
pubmed: 26248468
PLoS One. 2013 Jul 15;8(7):e69199
pubmed: 23869236
J Neurophysiol. 2011 Nov;106(5):2322-45
pubmed: 21795627
Neuroscientist. 2016 Apr;22(2):108-18
pubmed: 26044399
Eur J Neurol. 2014 Jun;21(6):874-83
pubmed: 24612409
Brain. 2015 Oct;138(Pt 10):2920-33
pubmed: 26115677
Neurol Sci. 2019 Oct;40(10):2051-2063
pubmed: 31115799
Neuropsychiatr Dis Treat. 2010 Sep 07;6:401-8
pubmed: 20856604
J Neurol Neurosurg Psychiatry. 2012 Mar;83(3):258-62
pubmed: 22205676
Eur Radiol. 2019 Dec;29(12):6634-6642
pubmed: 31139970
Neuroimage. 2018 May 15;172:437-449
pubmed: 29408539
Parkinsonism Relat Disord. 2014 Jan;20 Suppl 1:S118-22
pubmed: 24262161
AJNR Am J Neuroradiol. 2008 Oct;29(9):1692-7
pubmed: 18653686
J Neurol Sci. 2009 Dec 15;287(1-2):138-42
pubmed: 19717167
Neurosci Lett. 2016 Oct 28;633:210-214
pubmed: 27687715