Sarcoidosis-lymphoma syndrome with portal hypertension: diagnostic clues and approach.
Hepatic sarcoidosis
Laparoscopic liver biopsy
PET/CT
Portal hypertension
Primary hepatic Hodgkin lymphoma
Sarcoidosis-lymphoma syndrome
Journal
Radiology case reports
ISSN: 1930-0433
Titre abrégé: Radiol Case Rep
Pays: Netherlands
ID NLM: 101467888
Informations de publication
Date de publication:
Aug 2021
Aug 2021
Historique:
received:
20
04
2021
revised:
14
05
2021
accepted:
15
05
2021
entrez:
28
6
2021
pubmed:
29
6
2021
medline:
29
6
2021
Statut:
epublish
Résumé
Sarcoidosis-lymphoma syndrome associated with portal hypertension is very rare. A 68-year-old female presented with a 5 kg weight loss in 6 months. Soluble interleukin-2 receptor activity was increased and total platelet count was decreased. Contrast-enhanced computed tomography showed the presence of hepatosplenomegaly and a 3 cm-sized tumor in segment 3 of the liver. The hepatic venous catheterization showed mild portal hypertension. On fluorodeoxyglucose-positron emission tomography/computed tomography, progressive malignant lymphoma was suspected. However, bone marrow biopsy showed multiple noncaseating granulomas. A laparoscopic liver biopsy revealed that the liver tumor had features of Hodgkin lymphoma. There were multiple noncaseating epithelioid granulomas in the portal tracts of the liver. Splenectomy for splenomegaly and partial hepatectomy for the liver tumor were performed. Pathological examination of the resected specimens revealed multiple noncaseating epithelioid granulomas in the liver and spleen. Histopathology of the liver tumor confirmed classic Hodgkin lymphoma with mixed cellularity. We conclude that hepatic venous catheterization, positron emission tomography/computed tomography, and pathological examinations of bone marrow, liver, and spleen are crucial for the diagnosis of sarcoidosis-lymphoma syndrome associated with portal hypertension.
Identifiants
pubmed: 34178191
doi: 10.1016/j.radcr.2021.05.045
pii: S1930-0433(21)00340-X
pmc: PMC8213984
doi:
Types de publication
Case Reports
Langues
eng
Pagination
2192-2201Informations de copyright
© 2021 The Authors. Published by Elsevier Inc. on behalf of University of Washington.
Références
World J Surg. 2010 Feb;34(2):320-6
pubmed: 20012612
Br J Cancer. 1986 Sep;54(3):467-73
pubmed: 3756082
Radiol Case Rep. 2016 Dec 22;12(1):45-49
pubmed: 28228877
Am J Respir Crit Care Med. 1999 Aug;160(2):736-55
pubmed: 10430755
J Nucl Med. 1998 Jul;39(7):1160-6
pubmed: 9669387
Hepatogastroenterology. 2007 Sep;54(78):1847-9
pubmed: 18019732
Cureus. 2021 Feb 8;13(2):e13227
pubmed: 33728177
J Nucl Med. 2006 Oct;47(10):1571-6
pubmed: 17015889
J Gastroenterol Hepatol. 2004 Jul;19(7):732-7
pubmed: 15209617
Methods Mol Biol. 2019;1866:267-271
pubmed: 30725422
BMC Med Imaging. 2016 Jan 08;16:1
pubmed: 26746426
J Gastroenterol Hepatol. 2019 Feb;34(2):418-424
pubmed: 30101431
N Engl J Med. 2010 Aug 12;363(7):640-52
pubmed: 20818855
Hepatogastroenterology. 1996 May-Jun;43(9):651-7
pubmed: 8799410
J Gastroenterol. 2017 Dec;52(12):1252-1257
pubmed: 28477171
Radiol Case Rep. 2020 Dec 24;16(3):564-570
pubmed: 33408799
Am J Gastroenterol. 2008 Dec;103(12):3184-92; quiz 3193
pubmed: 18853979
NMC Case Rep J. 2019 Mar 21;6(2):61-64
pubmed: 31016103
World J Surg Oncol. 2013 Sep 18;11:235
pubmed: 24047276
Intern Med. 2020 Mar 1;59(5):641-648
pubmed: 31666466
Case Rep Gastroenterol. 2012 Jan;6(1):183-9
pubmed: 22679408
Lancet. 2015 Apr 11;385(9976):1418-27
pubmed: 25539730
Insights Imaging. 2015 Dec;6(6):679-92
pubmed: 26443451
Medicine (Baltimore). 1970 Sep;49(5):375-95
pubmed: 5495893
BMJ Case Rep. 2017 Dec 14;2017:
pubmed: 29246929
Eur Respir J. 2010 Nov;36(5):1207-9
pubmed: 21037370
Surgery. 1971 Feb;69(2):294-9
pubmed: 5312801
Transl Gastroenterol Hepatol. 2019 May 25;4:41
pubmed: 31231708