HGF and MET: From Brain Development to Neurological Disorders.
HGF
MET
amyotrophic lateral sclerosis
autism
cerebral ischemia
multiple sclerosis
spinal cord injury
synaptogenesis
Journal
Frontiers in cell and developmental biology
ISSN: 2296-634X
Titre abrégé: Front Cell Dev Biol
Pays: Switzerland
ID NLM: 101630250
Informations de publication
Date de publication:
2021
2021
Historique:
received:
21
03
2021
accepted:
30
04
2021
entrez:
28
6
2021
pubmed:
29
6
2021
medline:
29
6
2021
Statut:
epublish
Résumé
Hepatocyte growth factor (HGF) and its tyrosine kinase receptor, encoded by the MET cellular proto-oncogene, are expressed in the nervous system from pre-natal development to adult life, where they are involved in neuronal growth and survival. In this review, we highlight, beyond the neurotrophic action, novel roles of HGF-MET in synaptogenesis during post-natal brain development and the connection between deregulation of MET expression and developmental disorders such as autism spectrum disorder (ASD). On the pharmacology side, HGF-induced MET activation exerts beneficial neuroprotective effects also in adulthood, specifically in neurodegenerative disease, and in preclinical models of cerebral ischemia, spinal cord injuries, and neurological pathologies, such as Alzheimer's disease (AD), amyotrophic lateral sclerosis (ALS), and multiple sclerosis (MS). HGF is a key factor preventing neuronal death and promoting survival through pro-angiogenic, anti-inflammatory, and immune-modulatory mechanisms. Recent evidence suggests that HGF acts on neural stem cells to enhance neuroregeneration. The possible therapeutic application of HGF and HGF mimetics for the treatment of neurological disorders is discussed.
Identifiants
pubmed: 34179015
doi: 10.3389/fcell.2021.683609
pmc: PMC8220160
doi:
Types de publication
Journal Article
Review
Langues
eng
Pagination
683609Informations de copyright
Copyright © 2021 Desole, Gallo, Vitacolonna, Montarolo, Bertolotto, Vivien, Comoglio and Crepaldi.
Déclaration de conflit d'intérêts
PC is a founder of the Benefit Company ‘METIS’. The remaining authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. The reviewer GM declared a shared affiliation, with no collaboration, with the authors to the handling editor at the time of the review.
Références
J Cereb Blood Flow Metab. 2015 Jun;35(6):1044-53
pubmed: 25712497
Nat Neurosci. 1999 Mar;2(3):213-7
pubmed: 10195212
J Neurosci. 2010 Apr 28;30(17):5843-54
pubmed: 20427645
Cancer Metastasis Rev. 2008 Mar;27(1):85-94
pubmed: 18175071
Stem Cell Investig. 2019 Dec 27;6:44
pubmed: 32039266
Nat Rev Cancer. 2002 Apr;2(4):289-300
pubmed: 12001990
J Pharmacol Exp Ther. 2013 Jan;344(1):141-54
pubmed: 23055539
J Med Genet. 2015 Aug;52(8):548-52
pubmed: 25941349
J Neurosci Res. 2012 Sep;90(9):1743-55
pubmed: 22535512
Neurosci Lett. 2008 Dec 19;448(1):125-9
pubmed: 18938210
Bioessays. 1993 Feb;15(2):105-11
pubmed: 8385942
J Neurosci. 2005 Feb 16;25(7):1645-53
pubmed: 15716400
Genes Dev. 1997 Dec 15;11(24):3341-50
pubmed: 9407027
Cancer Res. 2001 Aug 1;61(15):5911-8
pubmed: 11479233
Am J Pathol. 2001 Mar;158(3):1111-20
pubmed: 11238059
PLoS One. 2010 Nov 02;5(11):e15384
pubmed: 21072211
Dev Cell. 2020 May 4;53(3):344-357.e5
pubmed: 32302545
Dev Neurobiol. 2016 Oct;76(10):1160-81
pubmed: 26818605
Pediatrics. 2009 Mar;123(3):1018-24
pubmed: 19255034
Nature. 1996 Nov 14;384(6605):173-6
pubmed: 8906793
J Neurosci Res. 2010 Aug 1;88(10):2197-206
pubmed: 20175208
J Neurosci Res. 2020 Nov;98(11):2115-2129
pubmed: 31746037
Prog Neuropsychopharmacol Biol Psychiatry. 2007 Mar 30;31(2):412-5
pubmed: 17157424
Neurosci Res. 2010 Oct;68(2):137-41
pubmed: 20615438
Cell. 1994 Apr 22;77(2):261-71
pubmed: 7513258
Am J Psychiatry. 2010 Apr;167(4):436-43
pubmed: 20080979
J Comp Neurol. 2013 Oct 1;521(14):3241-59
pubmed: 23787772
Sci Rep. 2018 May 29;8(1):8316
pubmed: 29844434
J Biol Chem. 1998 Dec 4;273(49):32377-9
pubmed: 9829964
EMBO J. 1991 Oct;10(10):2867-78
pubmed: 1655405
Am J Physiol Renal Physiol. 2008 Feb;294(2):F326-35
pubmed: 18032545
Cell. 1996 Nov 1;87(3):531-42
pubmed: 8898205
J Comp Neurol. 2009 Apr 10;513(5):511-31
pubmed: 19226509
Eur Rev Med Pharmacol Sci. 2016 Nov;20(22):4654-4663
pubmed: 27906439
Biochim Biophys Acta. 2004 Feb 2;1644(1):9-15
pubmed: 14741740
Brain Res Dev Brain Res. 1997 Sep 20;102(2):299-303
pubmed: 9352114
Chem Sci. 2015 Mar 1;6(3):2110-2121
pubmed: 28717459
Genes Dev. 2009 Jun 1;23(11):1289-302
pubmed: 19487570
Rev Neurosci. 2008;19(4-5):341-61
pubmed: 19145989
Hum Hered. 2019;84(3):109-116
pubmed: 31801140
Eur J Pharmacol. 2006 Mar 27;535(1-3):114-24
pubmed: 16516191
J Cell Sci. 1998 Jan;111 ( Pt 2):237-47
pubmed: 9405310
Sci Rep. 2020 Jan 20;10(1):630
pubmed: 31959813
Nature. 1995 Feb 23;373(6516):699-702
pubmed: 7854452
BMC Biol. 2014 Aug 14;12:56
pubmed: 25124859
Circulation. 2003 Mar 18;107(10):1411-7
pubmed: 12642363
Nature. 1995 Aug 31;376(6543):768-71
pubmed: 7651534
Stem Cells Int. 2012;2012:915160
pubmed: 23093979
J Neurodev Disord. 2011 Sep;3(3):282-92
pubmed: 21509596
J Cereb Blood Flow Metab. 1999 May;19(5):495-501
pubmed: 10326716
Acta Neuropathol Commun. 2019 Jun 12;7(1):96
pubmed: 31189468
FEBS Lett. 1993 Aug 9;328(1-2):25-9
pubmed: 8344430
J Neurosci Res. 1996 Mar 01;43(5):554-64
pubmed: 8833090
Nat Neurosci. 2012 Jun;15(6):862-70
pubmed: 22610068
Pharmacol Rev. 1999 Mar;51(1):7-61
pubmed: 10049997
Nat Rev Cancer. 2018 Jun;18(6):341-358
pubmed: 29674709
Theranostics. 2019 Apr 6;9(7):2115-2128
pubmed: 31037160
Cell Signal. 2008 May;20(5):825-35
pubmed: 18262389
Neurol Res. 2001 Jun;23(4):417-24
pubmed: 11428524
J Neurosci. 2000 Jan 1;20(1):326-37
pubmed: 10627610
J Neurosci. 2011 Aug 3;31(31):11144-58
pubmed: 21813676
Int J Mol Sci. 2020 Nov 12;21(22):
pubmed: 33198383
J Neurosci Res. 2000 Feb 15;59(4):489-96
pubmed: 10679787
Neurosci Res. 2007 Dec;59(4):446-56
pubmed: 17935811
Mol Cell Neurosci. 2003 Sep;24(1):190-7
pubmed: 14550779
Science. 1991 Feb 15;251(4995):802-4
pubmed: 1846706
J Biol Chem. 2004 Feb 13;279(7):5237-43
pubmed: 14625309
J Cell Biol. 1994 Jul;126(2):485-94
pubmed: 8034747
Nature. 1998 Jan 15;391(6664):285-8
pubmed: 9440692
Eur J Hum Genet. 2009 Jun;17(6):749-58
pubmed: 19002214
Cell Cycle. 2006 Jul;5(14):1560-8
pubmed: 16861928
Biosci Rep. 2018 Sep 20;38(5):
pubmed: 30143582
J Cell Biol. 1992 Nov;119(3):629-41
pubmed: 1383237
Eur J Neurosci. 2000 Oct;12(10):3453-61
pubmed: 11029614
Am J Physiol Gastrointest Liver Physiol. 2007 Feb;292(2):G639-46
pubmed: 17068118
Exp Neurol. 2008 Feb;209(2):294-301
pubmed: 17617407
J Neurosci. 2011 Aug 10;31(32):11437-42
pubmed: 21832174
Neuroreport. 2008 May 7;19(7):765-9
pubmed: 18418254
Ann Neurol. 2007 Sep;62(3):243-50
pubmed: 17696172
Cell Commun Signal. 2020 Apr 15;18(1):62
pubmed: 32293472
Development. 1997 Aug;124(15):2903-13
pubmed: 9247333
Biochem Biophys Res Commun. 2009 Mar 6;380(2):333-7
pubmed: 19171123
Neurosci Lett. 2006 Oct 23;407(2):141-5
pubmed: 16973272
Exp Cell Res. 2013 Sep 10;319(15):2368-74
pubmed: 23769912
Hypertension. 2001 May;37(5):1341-8
pubmed: 11358951
J Pharmacol Exp Ther. 2014 Nov;351(2):390-402
pubmed: 25187433
Glycobiology. 2006 Aug;16(8):702-10
pubmed: 16624895
Nat Rev Neurosci. 2016 Aug;17(8):467-84
pubmed: 27256553
Exp Neurol. 2020 Aug;330:113359
pubmed: 32428505
Mol Psychiatry. 2016 Jul;21(7):925-35
pubmed: 26728565
J Neurochem. 2002 Apr;81(2):365-78
pubmed: 12064484
J Neurosci Res. 2007 Aug 15;85(11):2332-42
pubmed: 17549731
Amyotroph Lateral Scler Frontotemporal Degener. 2017 May;18(3-4):269-278
pubmed: 28166654
Colloids Surf B Biointerfaces. 2008 Feb 15;61(2):290-7
pubmed: 17942284
Front Neurosci. 2019 Jan 14;12:1022
pubmed: 30692904
Dev Neurobiol. 2019 Jan;79(1):36-50
pubmed: 30304576
J Biol Chem. 2008 Jul 25;283(30):21267-77
pubmed: 18495663
Proc Natl Acad Sci U S A. 2006 Nov 7;103(45):16834-9
pubmed: 17053076
Brain. 2011 Dec;134(Pt 12):3560-77
pubmed: 22058139
J Immunol. 2014 Sep 15;193(6):2743-52
pubmed: 25114100
Synapse. 2007 Apr;61(4):199-204
pubmed: 17230549
J Neurosci. 2008 Jun 4;28(23):5901-9
pubmed: 18524894
J Cell Physiol. 2013 Jan;228(1):149-62
pubmed: 22570218
FASEB J. 2018 Sep;32(9):5119-5131
pubmed: 29913557
Sci Rep. 2018 Jan 17;8(1):917
pubmed: 29343699
Proc Natl Acad Sci U S A. 2003 Oct 28;100(22):12718-23
pubmed: 14555767
J Cereb Blood Flow Metab. 2011 May;31(5):1251-62
pubmed: 21119693
Nat Rev Mol Cell Biol. 2010 Dec;11(12):834-48
pubmed: 21102609
Nature. 1989 Nov 23;342(6248):440-3
pubmed: 2531289
Nature. 1995 Feb 23;373(6516):702-5
pubmed: 7854453
Ann Clin Transl Neurol. 2015 May;2(5):465-78
pubmed: 26000320
Gene Ther. 2001 Aug;8(15):1167-73
pubmed: 11509947
Nature. 1987 May 21-27;327(6119):239-42
pubmed: 2952888
Gene Ther. 2000 Mar;7(5):417-27
pubmed: 10694824
Brain Nerve. 2019 Nov;71(11):1253-1260
pubmed: 31722311
Stroke. 2009 May;40(5):e331-9
pubmed: 19182083
J Biol Chem. 1993 May 5;268(13):9165-8
pubmed: 8387483
Am J Physiol Heart Circ Physiol. 2010 Apr;298(4):H1155-65
pubmed: 20061536
Trends Neurosci. 2009 Dec;32(12):638-47
pubmed: 19782411
Clin Sci (Lond). 2015 Dec;129(12):1173-93
pubmed: 26561593
Development. 2000 Apr;127(8):1751-66
pubmed: 10725250
J Heart Lung Transplant. 2007 Sep;26(9):935-43
pubmed: 17845933
Nat Neurosci. 2016 Nov;19(11):1442-1453
pubmed: 27668389
J Neurosci Res. 2011 Jan;89(1):86-95
pubmed: 20963849
J Neuroinflammation. 2011 Aug 30;8:110
pubmed: 21878126
Circulation. 2004 Jan 27;109(3):424-31
pubmed: 14707023
Neuroreport. 2004 Jan 19;15(1):5-8
pubmed: 15106821
EMBO J. 1992 Dec;11(13):4825-33
pubmed: 1334458
Stem Cell Res. 2013 Sep;11(2):758-71
pubmed: 23770801
Biomedicines. 2014 Oct 21;2(4):247-262
pubmed: 28548070
Exp Neurol. 1999 Aug;158(2):351-65
pubmed: 10415142
Cell. 2005 Sep 23;122(6):927-39
pubmed: 16179260
Transl Psychiatry. 2013 Oct 22;3:e316
pubmed: 24150225
Medicines (Basel). 2020 May 12;7(5):
pubmed: 32408562
Gene Ther. 2008 Apr;15(8):561-71
pubmed: 18288214
Proc Natl Acad Sci U S A. 2003 Oct 14;100(21):12039-44
pubmed: 14528000
Int J Mol Med. 2009 Aug;24(2):161-70
pubmed: 19578789
J Neuroinflammation. 2020 Feb 19;17(1):68
pubmed: 32075650
Proc Natl Acad Sci U S A. 2002 Nov 12;99(23):15200-5
pubmed: 12397180
Trends Cell Biol. 1998 Oct;8(10):404-10
pubmed: 9789329
Toxicology. 2003 Nov 15;193(1-2):67-78
pubmed: 14599768
Cell Death Dis. 2014 Apr 17;5:e1185
pubmed: 24743740
Cell Death Dis. 2011 Mar 17;2:e130
pubmed: 21412276
Front Neurosci. 2014 Jun 26;8:182
pubmed: 25018692
Glia. 2017 Nov;65(11):1794-1808
pubmed: 28722233
Development. 2004 Aug;131(15):3717-26
pubmed: 15229174
J Neurotrauma. 2020 Aug 1;37(15):1752-1758
pubmed: 32323609
PLoS One. 2011;6(11):e27706
pubmed: 22140459
Front Neurosci. 2015 Dec 16;9:469
pubmed: 26733784
Angew Chem Int Ed Engl. 2016 Jan 11;55(2):579-82
pubmed: 26592704
Exp Neurol. 2012 Jan;233(1):312-22
pubmed: 22079829
Proc Natl Acad Sci U S A. 2010 Apr 6;107(14):6424-9
pubmed: 20332205
Cereb Cortex. 2000 Oct;10(10):927-38
pubmed: 11007543
Biol Psychiatry. 2017 Mar 1;81(5):424-433
pubmed: 27837921
Nat Neurosci. 2001 Nov;4(11):1086-92
pubmed: 11687814
Biomed Pharmacother. 2018 May;101:682-690
pubmed: 29518615
Mayo Clin Proc. 2019 May;94(5):892-905
pubmed: 31054608
Neuron. 2003 Aug 28;39(5):767-77
pubmed: 12948444
J Neurosci. 2014 Dec 3;34(49):16166-79
pubmed: 25471559
Neuron. 2001 Apr;30(1):79-89
pubmed: 11343646
J Cell Biol. 2000 Jun 26;149(7):1419-32
pubmed: 10871282
J Neurosci. 2011 Apr 20;31(16):6053-8
pubmed: 21508230
Stem Cell Res Ther. 2020 May 14;11(1):178
pubmed: 32410702
Stem Cell Reports. 2017 Mar 14;8(3):509-518
pubmed: 28216143
Cell Mol Neurobiol. 2006 Jul-Aug;26(4-6):385-405
pubmed: 16633891
Brain Res Mol Brain Res. 1995 Sep;32(2):197-210
pubmed: 7500831
Neuron. 1996 Dec;17(6):1157-72
pubmed: 8982163
Proc Natl Acad Sci U S A. 2011 Aug 9;108(32):13035-40
pubmed: 21788476
Adv Sci (Weinh). 2020 Jul 06;7(17):1903809
pubmed: 32995116
J Neurochem. 2005 Dec;95(5):1277-86
pubmed: 16135073
J Neurosci. 1999 Dec 15;19(24):10778-88
pubmed: 10594061
Int J Mol Sci. 2020 Jan 19;21(2):
pubmed: 31963888
J Clin Pharmacol. 2019 May;59(5):677-687
pubmed: 30536581
Cell Tissue Res. 2018 Jan;371(1):1-6
pubmed: 29196810
Neurology. 2003 Feb 25;60(4):702-5
pubmed: 12601116
Acta Neurochir Suppl. 2000;76:311-6
pubmed: 11450033
J Neuropathol Exp Neurol. 2007 Nov;66(11):1037-44
pubmed: 17984685
J Neurosci Res. 2004 Nov 1;78(3):442-53
pubmed: 15389834
J Neurosci. 2011 Apr 13;31(15):5855-64
pubmed: 21490227
Neuron. 2012 Sep 6;75(5):904-15
pubmed: 22958829
Semin Cell Dev Biol. 2019 Nov;95:42-53
pubmed: 30639325
Hypertension. 2001 Feb;37(2 Pt 2):581-6
pubmed: 11230338
Biomed Res Int. 2014;2014:909657
pubmed: 25276829
Int J Cancer. 1996 Jul 17;67(2):248-55
pubmed: 8760595
Am J Hum Genet. 2009 Jul;85(1):25-39
pubmed: 19576567
Gene Ther. 2006 Dec;13(23):1639-44
pubmed: 16791285
J Cereb Blood Flow Metab. 1998 Apr;18(4):345-8
pubmed: 9538898
Eur J Biochem. 2000 Dec;267(24):6954-67
pubmed: 11106403
Curr Opin Neurobiol. 2007 Feb;17(1):103-11
pubmed: 17275283
Am J Pathol. 2005 Jun;166(6):1895-905
pubmed: 15920173
J Neurosci. 2007 Jan 10;27(2):431-45
pubmed: 17215404
Neurosci Lett. 2006 Oct 23;407(2):136-40
pubmed: 16973282
Hypertension. 2006 Apr;47(4):742-51
pubmed: 16505200
Cell Death Differ. 2018 Mar;25(3):486-541
pubmed: 29362479
Nat Rev Mol Cell Biol. 2003 Dec;4(12):915-25
pubmed: 14685170
Oncogene. 2004 Apr 12;23(16):2785-96
pubmed: 15077142
Int Rev Neurobiol. 2013;113:135-65
pubmed: 24290385
Brain Res. 2009 Mar 31;1263:10-22
pubmed: 19368826
Mol Ther. 2009 Jan;17(1):42-50
pubmed: 18941443
J Cereb Blood Flow Metab. 2006 Nov;26(11):1354-65
pubmed: 16511502
J Neurochem. 2006 May;97(3):772-83
pubmed: 16524371
J Neurosci. 2002 Aug 1;22(15):6537-48
pubmed: 12151533
Neuroscience. 2004;128(1):155-62
pubmed: 15450362
Int J Mol Sci. 2020 Oct 27;21(21):
pubmed: 33121208
Sci Adv. 2020 Apr 01;6(14):eaay2801
pubmed: 32270033
Neuron. 1998 May;20(5):835-46
pubmed: 9620689
Brain Res. 1999 Mar 13;821(2):356-67
pubmed: 10064822
Am J Pathol. 2008 Jul;173(1):30-41
pubmed: 18502824
J Pathol. 2005 Jan;205(1):50-6
pubmed: 15526350
Stem Cells. 2009 Feb;27(2):408-19
pubmed: 18988709
Am J Respir Cell Mol Biol. 2005 Apr;32(4):268-80
pubmed: 15626778
Proc Natl Acad Sci U S A. 2006 Mar 14;103(11):4046-51
pubmed: 16537482
Science. 1999 Dec 17;286(5448):2358-61
pubmed: 10600750
Development. 2014 May;141(10):1983-6
pubmed: 24803647