Global feather orientations changed by electric current.
biological sciences
cell biology
developmental biology
Journal
iScience
ISSN: 2589-0042
Titre abrégé: iScience
Pays: United States
ID NLM: 101724038
Informations de publication
Date de publication:
25 Jun 2021
25 Jun 2021
Historique:
received:
22
01
2021
revised:
18
04
2021
accepted:
27
05
2021
entrez:
28
6
2021
pubmed:
29
6
2021
medline:
29
6
2021
Statut:
epublish
Résumé
During chicken skin development, each feather bud exhibits its own polarity, but a population of buds organizes with a collective global orientation. We used embryonic dorsal skin, with buds aligned parallel to the rostral-caudal body axis, to explore whether exogenous electric fields affect feather polarity. Interestingly, brief exogenous current exposure prior to visible bud formation later altered bud orientations. Applying electric pulses perpendicular to the body rostral-caudal axis realigned bud growth in a collective swirl, resembling an electric field pointing toward the anode. Perturbed buds show normal molecular expression and morphogenesis except for their altered orientation. Epithelial-mesenchymal recombination demonstrates the effects of exogenous electric fields are mediated through the epithelium. Small-molecule channel inhibitor screens show Ca
Identifiants
pubmed: 34179734
doi: 10.1016/j.isci.2021.102671
pii: S2589-0042(21)00639-8
pmc: PMC8214094
doi:
Types de publication
Journal Article
Langues
eng
Pagination
102671Subventions
Organisme : NIAMS NIH HHS
ID : R01 AR078050
Pays : United States
Organisme : NIAMS NIH HHS
ID : R37 AR060306
Pays : United States
Informations de copyright
© 2021 The Author(s).
Déclaration de conflit d'intérêts
The authors declare no competing interests.
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