A Minireview on Temperature Dependent Protein Conformational Sampling.
Biphasic transition
Protein conformational sampling
Protein structure and function
Journal
The protein journal
ISSN: 1875-8355
Titre abrégé: Protein J
Pays: Netherlands
ID NLM: 101212092
Informations de publication
Date de publication:
08 2021
08 2021
Historique:
accepted:
19
06
2021
pubmed:
29
6
2021
medline:
25
12
2021
entrez:
28
6
2021
Statut:
ppublish
Résumé
In this minireview we discuss the role of the more subtle conformational change-protein conformational sampling and connect it to the classic relationship of protein structure and function. The theory of pre-existing functional states of protein are discussed in context of alternate protein conformational sampling. Last, we discuss how temperature, ligand binding and mutations affect the protein conformational sampling mode which is linked to the protein function regulation. The review includes several protein systems that showed temperature dependent protein conformational sampling. We also specifically included two enzyme systems, thermophilic alcohol dehydrogenase (ht-ADH) and thermolysin which we previously studied when discussing temperature dependent protein conformational sampling.
Identifiants
pubmed: 34181188
doi: 10.1007/s10930-021-10012-x
pii: 10.1007/s10930-021-10012-x
doi:
Substances chimiques
Proteins
0
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
545-553Informations de copyright
© 2021. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.
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