The feasibility of a fully synthetic and self-assembled peptide solution as submucosal injection material: a preliminary animal study.

Animals Dogs Feasibility Studies Gastric Mucosa Injections Peptides Poloxamer
Fully synthetic and self-assembled peptide solution endoscopic mucosal resection endoscopic submucosal dissection preliminary animal study submucosal injection material

Journal

Scandinavian journal of gastroenterology
ISSN: 1502-7708
Titre abrégé: Scand J Gastroenterol
Pays: England
ID NLM: 0060105

Informations de publication

Date de publication:
Aug 2021
Historique:
pubmed: 29 6 2021
medline: 19 8 2021
entrez: 28 6 2021
Statut: ppublish

Résumé

An injection solution is required to create a submucosal cushion (SMC) for safe endoscopic resection procedures. The aim of this preliminary animal study was to clarify the safety and efficacy of a novel fully synthetic and self-assembled peptide (FSSP) solution as a submucosal injection material (SMIM). To compare the submucosal-lifting properties, 0.3% FSSP, Eleview In both the colon and stomach, ANOVA for repeated measures showed the significant interaction between time and solution for the time-dependent change in the height. In the colon, FSSP created significantly higher SMC than NS 20 min after injection ( FSSP seems to be useful as a SMIM for endoscopic resection especially in the colon. Further studies are needed prior to clinical use of FSSP.

Sections du résumé

BACKGROUND AND AIM OBJECTIVE
An injection solution is required to create a submucosal cushion (SMC) for safe endoscopic resection procedures. The aim of this preliminary animal study was to clarify the safety and efficacy of a novel fully synthetic and self-assembled peptide (FSSP) solution as a submucosal injection material (SMIM).
METHOD METHODS
To compare the submucosal-lifting properties, 0.3% FSSP, Eleview
RESULTS RESULTS
In both the colon and stomach, ANOVA for repeated measures showed the significant interaction between time and solution for the time-dependent change in the height. In the colon, FSSP created significantly higher SMC than NS 20 min after injection (
CONCLUSION CONCLUSIONS
FSSP seems to be useful as a SMIM for endoscopic resection especially in the colon. Further studies are needed prior to clinical use of FSSP.

Identifiants

DOI: 10.1080/00365521.2021.1934727 PMID: 34181504
pubmed: 34181504
doi: 10.1080/00365521.2021.1934727
doi:

Substances chimiques

Peptides 0
SIC-8000 0
Poloxamer 106392-12-5

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

984-989

Auteurs

Ko Nakata (K)

Department of Gastroenterology and Hepatology, Gunma University Graduate School of Medicine, Maebashi, Japan.
ORCID: 0000-0002-0626-5670

Mathieu Pioche (M)

Gastroenterology and Endoscopy Unit, Pavillon L, Edouard Herriot Hospital, Lyon, France.
ORCID: 0000-0002-6482-2375

Shiko Kuribayashi (S)

Department of Gastroenterology and Hepatology, Gunma University Graduate School of Medicine, Maebashi, Japan.
ORCID: 0000-0002-5067-552X

Hirohito Tanaka (H)

Department of Gastroenterology and Hepatology, Gunma University Graduate School of Medicine, Maebashi, Japan.

Daisuke Uehara (D)

Department of Gastroenterology and Hepatology, Gunma University Graduate School of Medicine, Maebashi, Japan.
ORCID: 0000-0003-1093-9751

Kazue Nagai (K)

Research and Education Center of Health Sciences School of Health Sciences, Gunma University, Maebashi, Japan.
ORCID: 0000-0002-2562-2127

Thomas Lambin (T)

Gastroenterology and Endoscopy Unit, Pavillon L, Edouard Herriot Hospital, Lyon, France.

Thierry Ponchon (T)

Gastroenterology and Endoscopy Unit, Pavillon L, Edouard Herriot Hospital, Lyon, France.
ORCID: 0000-0001-6695-7452

Toshio Uraoka (T)

Department of Gastroenterology and Hepatology, Gunma University Graduate School of Medicine, Maebashi, Japan.
ORCID: 0000-0002-4425-4331

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › The feasibility of a fully synthetic and...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Carnivora › Pinnipedia › Canidae › Chiens › The feasibility of a fully synthetic and...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Caractéristiques des études épidémiologiques › Études de faisabilité › The feasibility of a fully synthetic and...
questionsmedicales.fr › Tissus › Membranes › Muqueuse › Muqueuse gastrique › The feasibility of a fully synthetic and...
questionsmedicales.fr › Thérapeutique › Traitement médicamenteux › Voies d'administration de substances chimiques et des médicaments › Injections › The feasibility of a fully synthetic and...
questionsmedicales.fr › Acides aminés, peptides et protéines › Peptides › The feasibility of a fully synthetic and...
questionsmedicales.fr › Technologie, industrie et agriculture › Produits manufacturés › Matériaux biomédicaux et dentaires › Polymères › Polyéthylène glycols › Poloxamère › The feasibility of a fully synthetic and...