Oxytocin receptors in the midbrain dorsal raphe are essential for postpartum maternal social and affective behaviors.
Anxiety
Behavioral despair
Dorsal raphe
Oxytocin
Perineuronal nets
Postpartum
Journal
Psychoneuroendocrinology
ISSN: 1873-3360
Titre abrégé: Psychoneuroendocrinology
Pays: England
ID NLM: 7612148
Informations de publication
Date de publication:
09 2021
09 2021
Historique:
received:
24
03
2021
revised:
07
06
2021
accepted:
15
06
2021
pubmed:
29
6
2021
medline:
15
3
2022
entrez:
28
6
2021
Statut:
ppublish
Résumé
Oxytocin receptors (OTRs) in the midbrain dorsal raphe (DR; the source of most forebrain serotonin) have recently been identified as a potential pharmacological target for treating numerous psychiatric disorders. However, almost all research on this topic has been conducted on males and the role of DR OTRs in female social and affective behaviors is mostly unknown. This may be particularly relevant during early motherhood, which is a time of high endogenous oxytocin signaling, but also a time of elevated risk for psychiatric dysfunction. To investigate whether OTRs in the DR are necessary for postpartum female social and affective behaviors, we constructed and then injected into the DR an adeno-associated virus permanently expressing an shRNA targeting OTR mRNA. We then observed a suite of social and affective behaviors postpartum. OTR knockdown in the maternal DR led to pup loss after parturition, decreased nursing, increased aggression, and increased behavioral despair. These effects of OTR knockdown in the DR may be due to disrupted neuroplasticity in the primary somatosensory cortex (S1), which mediates maternal sensitivity to the tactile cues from young, as we found significantly more plasticity-restricting perineuronal nets (PNNs) in the S1 rostral barrel field and fewer PNNs in the caudal barrel field of OTR-knockdown mothers. These results demonstrate that OTRs in the midbrain DR are essential for postpartum maternal social and affective behaviors, are involved in postpartum cortical plasticity, and suggest that pharmacotherapies targeting OTRs in the DR could be effective treatments for some peripartum affective disorders.
Identifiants
pubmed: 34182251
pii: S0306-4530(21)00206-7
doi: 10.1016/j.psyneuen.2021.105332
pmc: PMC8405581
mid: NIHMS1719403
pii:
doi:
Substances chimiques
Receptors, Oxytocin
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
105332Subventions
Organisme : NICHD NIH HHS
ID : R03 HD097085
Pays : United States
Informations de copyright
Copyright © 2021 Elsevier Ltd. All rights reserved.
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