Microbiota and human allergic diseases: the company we keep.
Journal
Current opinion in immunology
ISSN: 1879-0372
Titre abrégé: Curr Opin Immunol
Pays: England
ID NLM: 8900118
Informations de publication
Date de publication:
10 2021
10 2021
Historique:
received:
05
02
2021
revised:
27
03
2021
accepted:
03
06
2021
pubmed:
29
6
2021
medline:
11
3
2022
entrez:
28
6
2021
Statut:
ppublish
Résumé
Environmental, maternal and early life microbial/immune networks program human developmental trajectories and health outcomes and strongly modify allergic disease risk. The effects of environmental microbiota are illustrated by the 'farm effect' (the protection against asthma and allergy conferred by growing up on a traditional farm) and other natural experiments in populations exposed to microbe-rich environments. The role of gut microbiome maturation in the asthma/allergy trajectory is demonstrated by the most recent farm studies, which identified microbial metabolites specifically associated with asthma protection, and studies in other cohorts, which defined dynamic microbial community profiles associated with allergic disease phenotypes. Current and future studies in germ-free mice associated with gut microbiota from human disease states are providing novel mechanistic insights into the role of microbiota in shaping immune function and allergic disease susceptibility.
Identifiants
pubmed: 34182271
pii: S0952-7915(21)00070-4
doi: 10.1016/j.coi.2021.06.002
pmc: PMC8578191
mid: NIHMS1719393
pii:
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
215-220Subventions
Organisme : NIAID NIH HHS
ID : P01 AI148104
Pays : United States
Organisme : NIAID NIH HHS
ID : R21 AI133765
Pays : United States
Organisme : NIAID NIH HHS
ID : R21 AI144722
Pays : United States
Organisme : NHLBI NIH HHS
ID : R25 HL126140
Pays : United States
Informations de copyright
Copyright © 2021 Elsevier Ltd. All rights reserved.
Références
Nat Med. 2019 Jul;25(7):1164-1174
pubmed: 31235962
Lancet Respir Med. 2020 Nov;8(11):1094-1105
pubmed: 32220282
Nat Med. 2019 Mar;25(3):448-453
pubmed: 30643289
Nat Rev Immunol. 2010 Dec;10(12):861-8
pubmed: 21060319
Nat Med. 2014 Feb;20(2):159-66
pubmed: 24390308
Science. 2010 Dec 24;330(6012):1768-73
pubmed: 21205662
Nat Commun. 2018 Feb 16;9(1):707
pubmed: 29453431
Nat Med. 2019 Jun;25(6):884-889
pubmed: 31133693
Clin Exp Allergy. 2020 Jun;50(6):733-740
pubmed: 32270527
Nat Commun. 2018 Jan 10;9(1):141
pubmed: 29321519
Am J Respir Crit Care Med. 2021 Apr 1;203(7):802-808
pubmed: 33493428
J Allergy Clin Immunol. 2020 Mar;145(3):897-906
pubmed: 31669435
Proc Natl Acad Sci U S A. 2012 May 22;109(21):8334-9
pubmed: 22566627
Sci Transl Med. 2020 Nov 11;12(569):
pubmed: 33177184
Front Immunol. 2019 Oct 23;10:2494
pubmed: 31749800
J Allergy Clin Immunol. 2020 Dec;146(6):1358-1366
pubmed: 32693091
J Allergy Clin Immunol Pract. 2017 Jan - Feb;5(1):114-120.e2
pubmed: 27544711
J Allergy Clin Immunol. 2019 Dec;144(6):1638-1647.e3
pubmed: 31279007
Nat Microbiol. 2019 Nov;4(11):1851-1861
pubmed: 31332384
Cell. 2019 Oct 31;179(4):895-908.e21
pubmed: 31675498
Lancet. 2020 Sep 19;396(10254):854-866
pubmed: 32910907
Nature. 2012 May 09;486(7402):222-7
pubmed: 22699611
Clin Exp Allergy. 2015 May;45(5):891-901
pubmed: 25772429
Environ Int. 2020 Dec;145:106084
pubmed: 32977191
J Allergy Clin Immunol. 2019 Aug;144(2):442-454
pubmed: 30914378
N Engl J Med. 2016 Aug 4;375(5):411-421
pubmed: 27518660
J Allergy Clin Immunol. 2019 Nov;144(5):1391-1401.e10
pubmed: 31401285
Nat Med. 2020 Nov;26(11):1766-1775
pubmed: 33139948
J Clin Invest. 2021 Jan 19;131(2):
pubmed: 33463536
N Engl J Med. 2016 Nov 10;375(19):1898-1899
pubmed: 27959651
J Allergy Clin Immunol. 2021 Mar;147(3):910-920
pubmed: 32615170
Nature. 2020 Nov;587(7834):448-454
pubmed: 33149306
Clin Exp Allergy. 2020 Oct;50(10):1148-1158
pubmed: 32865840
J Allergy Clin Immunol. 2018 Sep;142(3):749-764.e3
pubmed: 29307657
Clin Exp Allergy. 2020 Mar;50(3):282-290
pubmed: 31581343
N Engl J Med. 2011 Feb 24;364(8):701-9
pubmed: 21345099
Sci Rep. 2020 Dec 31;10(1):22449
pubmed: 33384449
J Allergy Clin Immunol. 2019 Nov;144(5):1214-1227.e7
pubmed: 31279011
Nat Med. 2016 Oct;22(10):1187-1191
pubmed: 27618652
Sci Transl Med. 2015 Sep 30;7(307):307ra152
pubmed: 26424567
Mucosal Immunol. 2019 Jul;12(4):843-850
pubmed: 30976087
Nat Med. 2019 Jul;25(7):1089-1095
pubmed: 31209334
Nature. 2018 Mar 8;555(7695):210-215
pubmed: 29489753