Human Hippocampal Neurons Track Moments in a Sequence of Events.
human electrophysiology
human hippocampus
sequence learning
temporal coding
time cells
Journal
The Journal of neuroscience : the official journal of the Society for Neuroscience
ISSN: 1529-2401
Titre abrégé: J Neurosci
Pays: United States
ID NLM: 8102140
Informations de publication
Date de publication:
04 08 2021
04 08 2021
Historique:
received:
14
12
2020
revised:
31
05
2021
accepted:
06
06
2021
pubmed:
30
6
2021
medline:
23
11
2021
entrez:
29
6
2021
Statut:
ppublish
Résumé
An indispensable feature of episodic memory is our ability to temporally piece together different elements of an experience into a coherent memory. Hippocampal time cells-neurons that represent temporal information-may play a critical role in this process. Although these cells have been repeatedly found in rodents, it is still unclear to what extent similar temporal selectivity exists in the human hippocampus. Here, we show that temporal context modulates the firing activity of human hippocampal neurons during structured temporal experiences. We recorded neuronal activity in the human brain while patients of either sex learned predictable sequences of pictures. We report that human time cells fire at successive moments in this task. Furthermore, time cells also signaled inherently changing temporal contexts during empty 10 s gap periods between trials while participants waited for the task to resume. Finally, population activity allowed for decoding temporal epoch identity, both during sequence learning and during the gap periods. These findings suggest that human hippocampal neurons could play an essential role in temporally organizing distinct moments of an experience in episodic memory.
Identifiants
pubmed: 34183446
pii: JNEUROSCI.3157-20.2021
doi: 10.1523/JNEUROSCI.3157-20.2021
pmc: PMC8336696
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
6714-6725Informations de copyright
Copyright © 2021 the authors.
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