A Mesoscale Computational Model for Microvascular Oxygen Transfer.
Mesoscale model
Microcirculation
Oxygen transfer
Journal
Annals of biomedical engineering
ISSN: 1573-9686
Titre abrégé: Ann Biomed Eng
Pays: United States
ID NLM: 0361512
Informations de publication
Date de publication:
Dec 2021
Dec 2021
Historique:
received:
17
02
2021
accepted:
01
06
2021
pubmed:
30
6
2021
medline:
22
3
2022
entrez:
29
6
2021
Statut:
ppublish
Résumé
We address a mathematical model for oxygen transfer in the microcirculation. The model includes blood flow and hematocrit transport coupled with the interstitial flow, oxygen transport in the blood and the tissue, including capillary-tissue exchange effects. Moreover, the model is suited to handle arbitrarily complex vascular geometries. The purpose of this study is the validation of the model with respect to classical solutions and the further demonstration of its adequacy to describe the heterogeneity of oxygenation in the tissue microenvironment. Finally, we discuss the importance of these effects in the treatment of cancer using radiotherapy.
Identifiants
pubmed: 34184146
doi: 10.1007/s10439-021-02807-x
pii: 10.1007/s10439-021-02807-x
doi:
Types de publication
Journal Article
Validation Study
Langues
eng
Sous-ensembles de citation
IM
Pagination
3356-3373Informations de copyright
© 2021. Biomedical Engineering Society.
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