Genomewide Association Studies in Pharmacogenomics.
Journal
Clinical pharmacology and therapeutics
ISSN: 1532-6535
Titre abrégé: Clin Pharmacol Ther
Pays: United States
ID NLM: 0372741
Informations de publication
Date de publication:
09 2021
09 2021
Historique:
received:
02
04
2021
accepted:
15
06
2021
pubmed:
30
6
2021
medline:
15
9
2021
entrez:
29
6
2021
Statut:
ppublish
Résumé
The increasing availability of genotype data linked with information about drug-response phenotypes has enabled genomewide association studies (GWAS) that uncover genetic determinants of drug response. GWAS have discovered associations between genetic variants and both drug efficacy and adverse drug reactions. Despite these successes, the design of GWAS in pharmacogenomics (PGx) faces unique challenges. In this review, we analyze the last decade of GWAS in PGx. We review trends in publications over time, including the drugs and drug classes studied and the clinical phenotypes used. Several data sharing consortia have contributed substantially to the PGx GWAS literature. We anticipate increased focus on biobanks and highlight phenotypes that would best enable future PGx discoveries.
Identifiants
pubmed: 34185318
doi: 10.1002/cpt.2349
pmc: PMC8376796
mid: NIHMS1719722
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
637-648Subventions
Organisme : NHGRI NIH HHS
ID : U24 HG010615
Pays : United States
Organisme : FDA HHS
ID : U01 FD005978
Pays : United States
Organisme : Chan Zuckerberg Biohub
Organisme : NIGMS NIH HHS
ID : R01 GM139875
Pays : United States
Organisme : NIGMS NIH HHS
ID : R01 GM102365
Pays : United States
Organisme : NIGMS NIH HHS
ID : R01 GM117163
Pays : United States
Organisme : NLM NIH HHS
ID : T32 LM012409
Pays : United States
Informations de copyright
© 2021 The Authors. Clinical Pharmacology & Therapeutics published by Wiley Periodicals LLC on behalf of American Society for Clinical Pharmacology and Therapeutics.
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