Non-permissive SARS-CoV-2 infection in human neurospheres.
Brain
Neurospheres
New coronavirus
SARS-CoV-2
iPS
Journal
Stem cell research
ISSN: 1876-7753
Titre abrégé: Stem Cell Res
Pays: England
ID NLM: 101316957
Informations de publication
Date de publication:
07 2021
07 2021
Historique:
received:
04
02
2021
revised:
13
06
2021
accepted:
15
06
2021
pubmed:
30
6
2021
medline:
16
7
2021
entrez:
29
6
2021
Statut:
ppublish
Résumé
Coronavirus disease 2019 (COVID-19) was initially described as a viral infection of the respiratory tract. It is now known, however, that several other organs are affected, including the brain. Neurological manifestations such as stroke, encephalitis, and psychiatric conditions have been reported in COVID-19 patients, but the neurotropic potential of the virus is still debated. Herein, we sought to investigate SARS-CoV-2 infection in human neural cells. We demonstrated that SARS-CoV-2 infection of neural tissue is non-permissive, however, it can elicit inflammatory response and cell damage. These findings add to the hypothesis that most of the neural damage caused by SARS-CoV-2 infection is due to a systemic inflammation leading to indirect harmful effects on the central nervous system despite the absence of local viral replication.
Identifiants
pubmed: 34186311
pii: S1873-5061(21)00283-X
doi: 10.1016/j.scr.2021.102436
pmc: PMC8236004
pii:
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
102436Commentaires et corrections
Type : UpdateOf
Informations de copyright
Copyright © 2021 The Author(s). Published by Elsevier B.V. All rights reserved.
Références
Science. 2015 Jan 23;347(6220):1260419
pubmed: 25613900
Trends Neurosci. 2020 Jun;43(6):355-357
pubmed: 32359765
PLoS One. 2020 Nov 10;15(11):e0240345
pubmed: 33170902
Bioinformatics. 2018 Dec 1;34(23):4121-4123
pubmed: 29790939
Biol Psychiatry. 2021 Mar 1;89(5):e29-e30
pubmed: 33131716
J Neuroinflammation. 2008 Oct 17;5:45
pubmed: 18925972
J Transl Int Med. 2020 May 09;8(1):9-19
pubmed: 32435607
Mol Biol Evol. 2018 Jun 1;35(6):1547-1549
pubmed: 29722887
Lancet. 2020 Aug 1;396(10247):320-332
pubmed: 32682491
Infect Genet Evol. 2020 Jul;81:104260
pubmed: 32092483
Science. 2016 May 13;352(6287):816-8
pubmed: 27064148
Euro Surveill. 2020 Jan;25(3):
pubmed: 31992387
PLoS One. 2020 Oct 22;15(10):e0240991
pubmed: 33091047
Stem Cell Reports. 2021 Mar 9;16(3):505-518
pubmed: 33636110
Bull World Health Organ. 2020 Jul 01;98(7):495-504
pubmed: 32742035
Nature. 2020 Jul;583(7814):15-16
pubmed: 32606457
Lancet Neurol. 2020 Sep;19(9):713-715
pubmed: 32822622
J Virol. 2009 Oct;83(19):10314-8
pubmed: 19640993
J Infect Dis. 2020 Jul 23;222(4):556-563
pubmed: 32526012
Brain Behav Immun Health. 2021 Jul;14:100251
pubmed: 33842898
J Neurosci. 2005 Mar 9;25(10):2518-21
pubmed: 15758160
J Exp Med. 2021 Mar 1;218(3):
pubmed: 33433624
Cell. 2020 Aug 20;182(4):812-827.e19
pubmed: 32697968
Crit Care. 2020 Aug 12;24(1):495
pubmed: 32787909
Dev Biol. 1996 Oct 10;179(1):251-63
pubmed: 8873768
Cell. 2011 Feb 18;144(4):601-13
pubmed: 21295337
Clin Infect Dis. 2005 Oct 15;41(8):1089-96
pubmed: 16163626
Nature. 2020 May;581(7809):465-469
pubmed: 32235945
Front Pharmacol. 2019 Sep 12;10:1008
pubmed: 31572186
J Infect Dis. 2016 Mar 1;213(5):712-22
pubmed: 26486634
Stem Cell Res. 2021 May;53:102207
pubmed: 33677394
Biochim Biophys Acta Proteins Proteom. 2021 Aug;1869(8):140656
pubmed: 33857633
JAMA. 2020 Jun 23;323(24):2518-2520
pubmed: 32437497
Cell Stem Cell. 2020 Dec 3;27(6):937-950.e9
pubmed: 33010822
Nature. 2012 Sep 20;489(7416):391-399
pubmed: 22996553
Nat Neurosci. 2021 Feb;24(2):168-175
pubmed: 33257876
Brain Res. 1993 Jan 8;600(1):49-55
pubmed: 8422590
Pathogens. 2020 Oct 10;9(10):
pubmed: 33050463
SAGE Open Med. 2020 Oct 22;8:2050312120966456
pubmed: 33149912
Brain. 2021 May 7;144(4):1263-1276
pubmed: 33822001
J Pathol. 2004 Jun;203(2):631-7
pubmed: 15141377
Proc Natl Acad Sci U S A. 2020 Jul 14;117(28):16587-16595
pubmed: 32571934
Front Microbiol. 2019 Aug 07;10:1813
pubmed: 31440227
Front Immunol. 2019 Aug 16;10:1928
pubmed: 31474994
J Gen Virol. 2020 Jun;101(6):622-634
pubmed: 32375993
Pathol Res Pract. 2020 Sep;216(9):153097
pubmed: 32825963
J Neurol. 2020 Oct;267(10):2777-2789
pubmed: 32529575
Brain Behav Immun. 2020 Oct;89:594-600
pubmed: 32738287
J Med Virol. 2020 Jun;92(6):584-588
pubmed: 32083328
Cell. 2016 May 19;165(5):1238-1254
pubmed: 27118425
Dermatol Ther. 2020 Jul;33(4):e13591
pubmed: 32412679
Nat Rev Mol Cell Biol. 2007 Oct;8(10):839-45
pubmed: 17684528
Lancet. 2020 Jun 27;395(10242):e116
pubmed: 32593338
Infect Disord Drug Targets. 2020;20(4):407-408
pubmed: 32418532
Sci Rep. 2017 Jan 23;7:40780
pubmed: 28112162
Curr Med Chem. 2018;25(28):3333-3352
pubmed: 29484978
Lancet. 2020 Feb 15;395(10223):497-506
pubmed: 31986264
Lancet Microbe. 2020 Nov;1(7):e290-e299
pubmed: 33015653
Science. 2020 Mar 27;367(6485):1444-1448
pubmed: 32132184
Nat Commun. 2019 Sep 5;10(1):3890
pubmed: 31488835
Cell Stem Cell. 2020 Dec 3;27(6):951-961.e5
pubmed: 33113348
Transl Psychiatry. 2018 Feb 22;8(1):48
pubmed: 29467462
Cell. 2020 Sep 3;182(5):1284-1294.e9
pubmed: 32730807
Cell. 2007 Nov 30;131(5):861-72
pubmed: 18035408
Cell Res. 2020 Oct;30(10):928-931
pubmed: 32753756
Sci Adv. 2020 Jul 31;6(31):
pubmed: 32937591
Brain Behav Immun. 2020 Oct;89:579-586
pubmed: 32629042
Nat Med. 2020 Jul;26(7):1017-1032
pubmed: 32651579
Arch Virol. 2020 Dec;165(12):2937-2944
pubmed: 33025199
Lancet Neurol. 2020 Sep;19(9):767-783
pubmed: 32622375
Int J Infect Dis. 2020 Jul;96:567-569
pubmed: 32505878
Cell Transplant. 2012;21(7):1547-59
pubmed: 21975034
Mol Neurobiol. 2017 Dec;54(10):8071-8089
pubmed: 27889895
Science. 2020 Jul 3;369(6499):50-54
pubmed: 32358202
Nat Rev Immunol. 2020 Jun;20(6):363-374
pubmed: 32346093
Nucleic Acids Res. 1994 Nov 11;22(22):4673-80
pubmed: 7984417
Neuroscience. 2015 Aug 27;302:2-22
pubmed: 26117714
Nat Med. 2020 May;26(5):681-687
pubmed: 32327758
Stem Cell Res. 2016 May 27;17(1):102-106
pubmed: 27558611
Sci Rep. 2020 Jan 27;10(1):1218
pubmed: 31988337
Nucleic Acids Res. 2009 Apr;37(6):e45
pubmed: 19237396
J Immunol. 2004 Sep 15;173(6):4030-9
pubmed: 15356152
Nat Microbiol. 2020 Nov;5(11):1403-1407
pubmed: 32669681
Comput Appl Biosci. 1992 Jun;8(3):275-82
pubmed: 1633570
Neurosci Lett. 2003 Mar 13;339(1):62-6
pubmed: 12618301