Resilience of neural networks for locomotion.
caenorhabditis elegans
computational neuroscience
injury
lamprey
locomotion
mathematical modelling
reticulospinal
sensorimotor control
zebrafish
Journal
The Journal of physiology
ISSN: 1469-7793
Titre abrégé: J Physiol
Pays: England
ID NLM: 0266262
Informations de publication
Date de publication:
08 2021
08 2021
Historique:
received:
26
03
2021
accepted:
22
06
2021
pubmed:
30
6
2021
medline:
28
10
2021
entrez:
29
6
2021
Statut:
ppublish
Résumé
Locomotion is an essential behaviour for the survival of all animals. The neural circuitry underlying locomotion is therefore highly robust to a wide variety of perturbations, including injury and abrupt changes in the environment. In the short term, fault tolerance in neural networks allows locomotion to persist immediately after mild to moderate injury. In the longer term, in many invertebrates and vertebrates, neural reorganization including anatomical regeneration can restore locomotion after severe perturbations that initially caused paralysis. Despite decades of research, very little is known about the mechanisms underlying locomotor resilience at the level of the underlying neural circuits and coordination of central pattern generators (CPGs). Undulatory locomotion is an ideal behaviour for exploring principles of circuit organization, neural control and resilience of locomotion, offering a number of unique advantages including experimental accessibility and modelling tractability. In comparing three well-characterized undulatory swimmers, lampreys, larval zebrafish and Caenorhabditis elegans, we find similarities in the manifestation of locomotor resilience. To advance our understanding, we propose a comparative approach, integrating experimental and modelling studies, that will allow the field to begin identifying shared and distinct solutions for overcoming perturbations to persist in orchestrating this essential behaviour.
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.
Langues
eng
Sous-ensembles de citation
IM
Pagination
3825-3840Subventions
Organisme : New Jersey Commission on spinal Cord Research
ID : CSCR14ERG002
Organisme : New Jersey Institute of Technology
Organisme : National Science Foundation (NSF)
ID : DMS1951707
Organisme : The Engineering and Physical Sciences Research Council
ID : EP/S01540X/1
Organisme : National Science Foundation (NSF)
ID : IOS 1652582
Organisme : Marine Biological Laboratory (MBL), Eugene Bell Center Endowment Fund
Informations de copyright
© 2021 The Authors. The Journal of Physiology © 2021 The Physiological Society.
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