Covid-19 and pregnancy: the experience of a tertiary maternity hospital.
Adolescent
Adult
COVID-19
/ epidemiology
Female
Greece
/ epidemiology
Hospitals, Maternity
/ statistics & numerical data
Humans
Middle Aged
Pregnancy
Pregnancy Complications, Infectious
/ epidemiology
Pregnancy Outcome
/ epidemiology
Retrospective Studies
Tertiary Care Centers
/ statistics & numerical data
Young Adult
COVID‐19
SARS‐CoV‐2
maternal outcome
neonatal outcomes
obstetric outcomes
pregnancy
Journal
Journal of perinatal medicine
ISSN: 1619-3997
Titre abrégé: J Perinat Med
Pays: Germany
ID NLM: 0361031
Informations de publication
Date de publication:
27 Jul 2021
27 Jul 2021
Historique:
received:
06
02
2021
accepted:
14
04
2021
pubmed:
30
6
2021
medline:
17
7
2021
entrez:
29
6
2021
Statut:
epublish
Résumé
The aim of our study is to present the effect of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection in pregnancy and evaluate its impact on maternal and neonatal outcomes. We retrospectively reviewed the medical records of all COVID-19 positive pregnant women who were admitted to "Alexandra" maternity hospital from March to December 2020 (n=40). The infection status was determined via real-time polymerase chain reaction (RT-PCR) of nasopharyngeal swab specimen. We documented the demographic features, clinical status, pregnancy characteristics and maternal and fetal outcomes. Forty COVID-19 positive pregnant women were admitted to our clinic during the study period. Mean maternal age was 27.6 years. Gestational age (GA) ranged from 10-42 weeks of pregnancy with mean GA calculated at 38 In alignment to other studies, our data show that the course of coronavirus disease 2019 (COVID-19) during pregnancy in the majority of cases is mild and neonatal outcomes also appear favorable.
Identifiants
pubmed: 34187133
pii: jpm-2021-0070
doi: 10.1515/jpm-2021-0070
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
686-690Informations de copyright
© 2021 Walter de Gruyter GmbH, Berlin/Boston.
Références
Zhu, N, Zhang, D, Wang, W, Li, X, Yang, B, Song, J, et al.. A novel coronavirus from patients with pneumonia in China, 2019. N Engl J Med 2020;382:727–33. https://doi.org/10.1056/NEJMoa2001017.
WHO. Director-General’s opening remarks at the media briefing on COVID-19. Available from: https://www.who.int/director-general/speeches/detail/who-director-general-s-opening-remarks-at-the-media-briefing-on-covid-19---11-march-2020 [Accessed 24 Dec 2020].
WHO. Coronavirus disease (COVID-19) dashboard. Available from: https://covid19.who.int/ [Accessed 24 Dec 2020].
Novel coronavirus 2019 (COVID-19). ACOG. Available from: https://www.acog.org/clinical/clinical-guidance/practice-advisory/articles/2020/03/novel-coronavirus-2019 [Accessed 24 Dec 2020].
CDC COVID-19 Response Team. Preliminary estimates of the prevalence of selected underlying health conditions among patients with coronavirus disease 2019 – United States, February 12–March 28, 2020. MMWR Morb Mortal Wkly Rep 2020;69:382–6. https://doi.org/10.15585/mmwr.mm6913e2.
Zambrano, LD, Ellington, S, Strid, P, Galang, RR, Oduyebo, T, Tong, VT, et al.. Update: characteristics of symptomatic women of reproductive age with laboratory-confirmed SARS-CoV-2 infection by pregnancy status – United States, January 22–October 3, 2020. MMWR (Morb Mortal Wkly Rep) 2020;69:1641–7. https://doi.org/10.15585/mmwr.mm6944e3.
Dashraath, P, Wong, JIJ, Lim, MXK, Lim, LM, Li, S, Biswas, A, et al.. Coronavirus disease 2019 (COVID-19) pandemic and pregnancy. Am J Obstet Gynecol 2020;222:521–31. https://doi.org/10.1016/j.ajog.2020.03.021.
Warning, JC, McCracken, SA, Morris, JM. A balancing act: mechanisms by which the fetus avoids rejection by the maternal immune system. Reproduction 2011;141:715–24. https://doi.org/10.1530/REP-10-0360.
Kirtsman, M, Diambomba, Y, Poutanen, SM, Malinowski, AK, Vlachodimitropoulou, E, Parks, WT, et al.. Probable congenital SARS-CoV-2 infection in a neonate born to a woman with active SARS-CoV-2 infection. CMAJ (Can Med Assoc J) 2020;192:E647–50. https://doi.org/10.1503/cmaj.200821.
Vivanti, AJ, Vauloup-Fellous, C, Prevot, S, Zupan, V, Suffee, C, Do Cao, J, et al.. Transplacental transmission of SARS-CoV-2 infection. Nat Commun 2020;11:1–3572. https://doi.org/10.1038/s41467-020-17436-6.
Prabhu, M, Cagino, K, Matthews, KC, Friedlander, RL, Glynn, SM, Kubiak, JM, et al.. Pregnancy and postpartum outcomes in a universally tested population for SARS-CoV-2 in New York City: a prospective cohort study. BJOG An Int J Obstet Gynaecol 2020;127:1548–56. https://doi.org/10.1111/1471-0528.16403.
Shanes, ED, Mithal, LB, Otero, S, Azad, HA, Miller, ES, Goldstein, JA, et al.. Placental pathology in COVID-19. Am J Clin Pathol 2020;154:23–32. https://doi.org/10.1093/ajcp/aqaa089.
Smithgall, MC, Liu-Jarin, X, Hamele-Bena, D, Cimic, A, Mourad, M, Debelenko, L, et al.. Third-trimester placentas of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)-positive women: histomorphology, including viral immunohistochemistry and in-situ hybridization. Histopathology 2020;77:994–9. https://doi.org/10.1111/his.14215.
World Medical Association. World Medical Association Declaration of Helsinki: ethical principles for medical research involving human subjects. J Am Med Assoc 2013;310:2191–4. https://doi.org/10.1001/jama.2013.281053.
Sutton, D, Fuchs, K, D’Alton, M, Goffman, D. Universal screening for SARS-CoV-2 in women admitted for delivery. N Engl J Med 2020;382:2163–4. https://doi.org/10.1056/NEJMc2009316.
Chen, H, Guo, J, Wang, C, Luo, F, Yu, X, Zhang, W, et al.. Clinical characteristics and intrauterine vertical transmission potential of COVID-19 infection in nine pregnant women: a retrospective review of medical records. Lancet 2020;395:809–15. https://doi.org/10.1016/S0140-6736(20)30360-3.
RCOG. Coronavirus (COVID-19) infection and pregnancy. Available from: https://www.rcog.org.uk/coronavirus-pregnancy [Accessed 24 Dec 2020].
RCOG. Coronavirus (COVID-19) infection in pregnancy. Information for healthcare professionals, Version 13; 2021. https://www.rcog.org.uk/globalassets/documents/guidelines/2021-02-19-coronavirus-covid-19-infection-in-pregnancy-v13.pdf [Accessed 19 Feb 2021].
Novel Coronavirus 2019 (COVID-19). ACOG. Available from: https://www.acog.org/clinical/clinical-guidance/practice-advisory/articles/2020/03/novel-coronavirus-2019 [Accessed 10 Jan 2021].
Api, O, Sen, C, Debska, M, Saccone, G, D’Antonio, F, Volpe, N, et al.. Clinical management of coronavirus disease 2019 (COVID-19) in pregnancy: recommendations of WAPM-World Association of Perinatal Medicine. J Perinat Med 2020;48:857–66. https://doi.org/10.1515/jpm-2020-0265.
FDA. FDA takes key action in fight against COVID-19 by issuing emergency use authorization for first COVID-19 vaccine. US FDA. Available from: https://www.fda.gov/news-events/press-announcements/fda-takes-key-action-fight-against-covid-19-issuing-emergency-use-authorization-first-covid-19 [Accessed 24 Dec 2020].
ACOG. Vaccinating pregnant and lactating patients against COVID 19. Practice advisory. Available from: https://www.acog.org/clinical/clinical-guidance/practice-advisory/articles/2020/12/vaccinating-pregnant-and-lactating-patients-against-covid-19 [Accessed 24 Dec 2020].
Schalkwyk, V. SOGC statement on COVID-19 vaccination in pregnancy; 2020. Available from: https://sogc.org/common/Uploaded%20files/Latest%20News/SOGC_Statement_COVID-19_Vaccination_in_Pregnancy.pdf [Accessed 18 Dec 2020].