Periodontal Disease and Breast Cancer Risk: Results from the Nurses' Health Study.
Journal
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology
ISSN: 1538-7755
Titre abrégé: Cancer Epidemiol Biomarkers Prev
Pays: United States
ID NLM: 9200608
Informations de publication
Date de publication:
09 2021
09 2021
Historique:
received:
23
02
2021
revised:
13
05
2021
accepted:
15
06
2021
pubmed:
1
7
2021
medline:
9
3
2022
entrez:
30
6
2021
Statut:
ppublish
Résumé
While periodontal disease has been linked to increased cancer risk, studies regarding an association with breast cancer are limited. We examined the relationship between self-reported diagnosis of periodontal bone loss and incidence of breast cancer in a large, prospective cohort study, the Nurses' Health Study (1998-2014). We calculated HRs using Cox proportional hazards modeling, adjusting for risk factors common to both periodontal disease and breast cancer. During 1,023,647 person-years of follow-up, 5,110 of breast cancer cases were reported. We observed no association between periodontal disease and overall breast cancer risk (HR, 1.02; 95% confidence interval: 0.94-1.10); the association was not modified by smoking status, or other breast cancer risk factors or by breast tumor subtypes. We did not observe any association between periodontal disease and breast cancer risk. Given inconsistent findings in the literature, further research with standardized clinical measures of periodontitis is warranted.
Sections du résumé
BACKGROUND
While periodontal disease has been linked to increased cancer risk, studies regarding an association with breast cancer are limited.
METHODS
We examined the relationship between self-reported diagnosis of periodontal bone loss and incidence of breast cancer in a large, prospective cohort study, the Nurses' Health Study (1998-2014). We calculated HRs using Cox proportional hazards modeling, adjusting for risk factors common to both periodontal disease and breast cancer.
RESULTS
During 1,023,647 person-years of follow-up, 5,110 of breast cancer cases were reported. We observed no association between periodontal disease and overall breast cancer risk (HR, 1.02; 95% confidence interval: 0.94-1.10); the association was not modified by smoking status, or other breast cancer risk factors or by breast tumor subtypes.
CONCLUSIONS
We did not observe any association between periodontal disease and breast cancer risk.
IMPACT
Given inconsistent findings in the literature, further research with standardized clinical measures of periodontitis is warranted.
Identifiants
pubmed: 34187855
pii: 1055-9965.EPI-21-0257
doi: 10.1158/1055-9965.EPI-21-0257
pmc: PMC8419105
mid: NIHMS1722157
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1757-1760Subventions
Organisme : NCI NIH HHS
ID : P01 CA087969
Pays : United States
Organisme : NCI NIH HHS
ID : R25 CA113951
Pays : United States
Organisme : NCI NIH HHS
ID : T32 CA113951
Pays : United States
Organisme : NCI NIH HHS
ID : UM1 CA186107
Pays : United States
Informations de copyright
©2021 American Association for Cancer Research.
Références
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pubmed: 32385885
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pubmed: 11989206
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pubmed: 15864280
Front Oncol. 2018 Dec 12;8:601
pubmed: 30619743
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pubmed: 32385880
Cancer Prev Res (Phila). 2020 Dec;13(12):1007-1016
pubmed: 32727823