Association of Locus Coeruleus and Substantia Nigra Pathology With Cognitive and Motor Functions in Patients With Parkinson Disease.

Aged Brain Mapping / methods Cognitive Dysfunction / diagnostic imaging Female Humans Locus Coeruleus / diagnostic imaging Magnetic Resonance Imaging Male Melanins / analysis Motor Activity / physiology Parkinson Disease / complications Substantia Nigra / diagnostic imaging

Journal

Neurology
ISSN: 1526-632X
Titre abrégé: Neurology
Pays: United States
ID NLM: 0401060

Informations de publication

Date de publication:
07 09 2021
Historique:
received: 11 01 2021
accepted: 10 06 2021
pubmed: 1 7 2021
medline: 21 9 2021
entrez: 30 6 2021
Statut: ppublish

Résumé

To investigate the contribution of substantia nigra (SN) and locus coeruleus (LC) pathology to clinical signs and symptoms in Parkinson disease (PD) by applying neuromelanin-weighted imaging. Forty-seven patients with PD and 53 matched controls underwent motor assessment, a neuropsychological test battery, and neuromelanin-weighted MRI. Patients with PD were enrolled after fulfilling the criteria for clinically established PD as defined by the Movement Disorders Society Clinical Diagnostic Criteria. Two independent raters identified SN and LC and calculated the contrast-to-noise ratio (CNR). The intrarater reliability demonstrated good reliability between raters with an intraclass correlation coefficient of 0.88 ( Neuromelanin imaging of the SN and LC is well-suited to map neurodegeneration in PD. Neuromelanin pathology of the SN correlates with motor dysfunction whereas LC pathology is related to cognitive impairment. Neuromelanin-weighted imaging of the LC could thus serve as an imaging marker of executive and other cognitive dysfunction in PD. This study provides Class I evidence that neuromelanin-weighted imaging was associated with the severity of various signs and symptoms in patients with PD.

Identifiants

DOI: 10.1212/WNL.0000000000012444 PMID: 34187859
pubmed: 34187859
pii: WNL.0000000000012444
doi: 10.1212/WNL.0000000000012444
doi:

Substances chimiques

Melanins 0
neuromelanin 0

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

e1007-e1016

Informations de copyright

© 2021 American Academy of Neurology.

Auteurs

Jannik Prasuhn (J)

From the Departments of Neurology (J.P., A.F., R.S., F.L., S.D., T.F.M., H.H., M.H., N.B.), Ophthalmology (M.P.), and Psychiatry (R.S., M.K.), University Medical Center Schleswig-Holstein, Campus Lübeck; Institute of Neurogenetics (J.P., R.S., F.L., S.D., M.K., H.H., N.B.), Center of Brain, Behavior and Metabolism (J.P., M.K., T.F.M., H.H., M.H., N.B.), Laboratory for Angiogenesis and Ocular Cell Transplantation (M.P.), and Institute of Psychology II (T.F.M., M.H.), University of Lübeck, Germany.

Michelle Prasuhn (M)

From the Departments of Neurology (J.P., A.F., R.S., F.L., S.D., T.F.M., H.H., M.H., N.B.), Ophthalmology (M.P.), and Psychiatry (R.S., M.K.), University Medical Center Schleswig-Holstein, Campus Lübeck; Institute of Neurogenetics (J.P., R.S., F.L., S.D., M.K., H.H., N.B.), Center of Brain, Behavior and Metabolism (J.P., M.K., T.F.M., H.H., M.H., N.B.), Laboratory for Angiogenesis and Ocular Cell Transplantation (M.P.), and Institute of Psychology II (T.F.M., M.H.), University of Lübeck, Germany.
ORCID: 0000-0001-7304-2963

Anja Fellbrich (A)

From the Departments of Neurology (J.P., A.F., R.S., F.L., S.D., T.F.M., H.H., M.H., N.B.), Ophthalmology (M.P.), and Psychiatry (R.S., M.K.), University Medical Center Schleswig-Holstein, Campus Lübeck; Institute of Neurogenetics (J.P., R.S., F.L., S.D., M.K., H.H., N.B.), Center of Brain, Behavior and Metabolism (J.P., M.K., T.F.M., H.H., M.H., N.B.), Laboratory for Angiogenesis and Ocular Cell Transplantation (M.P.), and Institute of Psychology II (T.F.M., M.H.), University of Lübeck, Germany.

Robert Strautz (R)

From the Departments of Neurology (J.P., A.F., R.S., F.L., S.D., T.F.M., H.H., M.H., N.B.), Ophthalmology (M.P.), and Psychiatry (R.S., M.K.), University Medical Center Schleswig-Holstein, Campus Lübeck; Institute of Neurogenetics (J.P., R.S., F.L., S.D., M.K., H.H., N.B.), Center of Brain, Behavior and Metabolism (J.P., M.K., T.F.M., H.H., M.H., N.B.), Laboratory for Angiogenesis and Ocular Cell Transplantation (M.P.), and Institute of Psychology II (T.F.M., M.H.), University of Lübeck, Germany.

Felicitas Lemmer (F)

From the Departments of Neurology (J.P., A.F., R.S., F.L., S.D., T.F.M., H.H., M.H., N.B.), Ophthalmology (M.P.), and Psychiatry (R.S., M.K.), University Medical Center Schleswig-Holstein, Campus Lübeck; Institute of Neurogenetics (J.P., R.S., F.L., S.D., M.K., H.H., N.B.), Center of Brain, Behavior and Metabolism (J.P., M.K., T.F.M., H.H., M.H., N.B.), Laboratory for Angiogenesis and Ocular Cell Transplantation (M.P.), and Institute of Psychology II (T.F.M., M.H.), University of Lübeck, Germany.

Shalida Dreischmeier (S)

From the Departments of Neurology (J.P., A.F., R.S., F.L., S.D., T.F.M., H.H., M.H., N.B.), Ophthalmology (M.P.), and Psychiatry (R.S., M.K.), University Medical Center Schleswig-Holstein, Campus Lübeck; Institute of Neurogenetics (J.P., R.S., F.L., S.D., M.K., H.H., N.B.), Center of Brain, Behavior and Metabolism (J.P., M.K., T.F.M., H.H., M.H., N.B.), Laboratory for Angiogenesis and Ocular Cell Transplantation (M.P.), and Institute of Psychology II (T.F.M., M.H.), University of Lübeck, Germany.

Meike Kasten (M)

From the Departments of Neurology (J.P., A.F., R.S., F.L., S.D., T.F.M., H.H., M.H., N.B.), Ophthalmology (M.P.), and Psychiatry (R.S., M.K.), University Medical Center Schleswig-Holstein, Campus Lübeck; Institute of Neurogenetics (J.P., R.S., F.L., S.D., M.K., H.H., N.B.), Center of Brain, Behavior and Metabolism (J.P., M.K., T.F.M., H.H., M.H., N.B.), Laboratory for Angiogenesis and Ocular Cell Transplantation (M.P.), and Institute of Psychology II (T.F.M., M.H.), University of Lübeck, Germany.

Thomas F Münte (TF)

From the Departments of Neurology (J.P., A.F., R.S., F.L., S.D., T.F.M., H.H., M.H., N.B.), Ophthalmology (M.P.), and Psychiatry (R.S., M.K.), University Medical Center Schleswig-Holstein, Campus Lübeck; Institute of Neurogenetics (J.P., R.S., F.L., S.D., M.K., H.H., N.B.), Center of Brain, Behavior and Metabolism (J.P., M.K., T.F.M., H.H., M.H., N.B.), Laboratory for Angiogenesis and Ocular Cell Transplantation (M.P.), and Institute of Psychology II (T.F.M., M.H.), University of Lübeck, Germany.

Henrike Hanssen (H)

From the Departments of Neurology (J.P., A.F., R.S., F.L., S.D., T.F.M., H.H., M.H., N.B.), Ophthalmology (M.P.), and Psychiatry (R.S., M.K.), University Medical Center Schleswig-Holstein, Campus Lübeck; Institute of Neurogenetics (J.P., R.S., F.L., S.D., M.K., H.H., N.B.), Center of Brain, Behavior and Metabolism (J.P., M.K., T.F.M., H.H., M.H., N.B.), Laboratory for Angiogenesis and Ocular Cell Transplantation (M.P.), and Institute of Psychology II (T.F.M., M.H.), University of Lübeck, Germany.

Marcus Heldmann (M)

From the Departments of Neurology (J.P., A.F., R.S., F.L., S.D., T.F.M., H.H., M.H., N.B.), Ophthalmology (M.P.), and Psychiatry (R.S., M.K.), University Medical Center Schleswig-Holstein, Campus Lübeck; Institute of Neurogenetics (J.P., R.S., F.L., S.D., M.K., H.H., N.B.), Center of Brain, Behavior and Metabolism (J.P., M.K., T.F.M., H.H., M.H., N.B.), Laboratory for Angiogenesis and Ocular Cell Transplantation (M.P.), and Institute of Psychology II (T.F.M., M.H.), University of Lübeck, Germany.

Norbert Brüggemann (N)

From the Departments of Neurology (J.P., A.F., R.S., F.L., S.D., T.F.M., H.H., M.H., N.B.), Ophthalmology (M.P.), and Psychiatry (R.S., M.K.), University Medical Center Schleswig-Holstein, Campus Lübeck; Institute of Neurogenetics (J.P., R.S., F.L., S.D., M.K., H.H., N.B.), Center of Brain, Behavior and Metabolism (J.P., M.K., T.F.M., H.H., M.H., N.B.), Laboratory for Angiogenesis and Ocular Cell Transplantation (M.P.), and Institute of Psychology II (T.F.M., M.H.), University of Lübeck, Germany. norbert.brueggemann@neuro.uni-luebeck.de.

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Classifications MeSH

questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › Sujet âgé › Association of Locus Coeruleus and Substantia...
questionsmedicales.fr › Techniques d'investigation › Neuroimagerie › Neuroimagerie fonctionnelle › Cartographie cérébrale › Association of Locus Coeruleus and Substantia...
questionsmedicales.fr › Troubles mentaux › Troubles neurocognitifs › Troubles de la cognition › Dysfonctionnement cognitif › Association of Locus Coeruleus and Substantia...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Association of Locus Coeruleus and Substantia...
questionsmedicales.fr › Système nerveux › Système nerveux central › Encéphale › Tronc cérébral › Rhombencéphale › Métencéphale › Pont › Tegmentum pontin › Locus ceruleus › Association of Locus Coeruleus and Substantia...
questionsmedicales.fr › Diagnostic › Techniques et procédures diagnostiques › Imagerie diagnostique › Tomographie › Imagerie par résonance magnétique › Association of Locus Coeruleus and Substantia...
questionsmedicales.fr › Facteurs biologiques › Pigments biologiques › Mélanines › Association of Locus Coeruleus and Substantia...
questionsmedicales.fr › Phénomènes physiologiques de l'appareil locomoteur et du système nerveux › Phénomènes physiologiques du système locomoteur › Mouvement › Activité motrice › Association of Locus Coeruleus and Substantia...
questionsmedicales.fr › Maladies du système nerveux › Maladies neurodégénératives › Maladie de Parkinson › Association of Locus Coeruleus and Substantia...
questionsmedicales.fr › Système nerveux › Système nerveux central › Encéphale › Tronc cérébral › Mésencéphale › Pédoncule cérébral › Substantia nigra › Association of Locus Coeruleus and Substantia...