Development of a library of laminin-mimetic peptide hydrogels for control of nucleus pulposus cell behaviors.
Intervertebral disc
integrin
mechanobiology
poly(ethylene) glycol
syndecan
Journal
Journal of tissue engineering
ISSN: 2041-7314
Titre abrégé: J Tissue Eng
Pays: England
ID NLM: 101550131
Informations de publication
Date de publication:
Historique:
received:
24
03
2021
accepted:
12
05
2021
entrez:
30
6
2021
pubmed:
1
7
2021
medline:
1
7
2021
Statut:
epublish
Résumé
The nucleus pulposus (NP) of the intervertebral disc plays a critical role in distributing mechanical loads to the axial skeleton. Alterations in NP cells and, consequently, NP matrix are some of the earliest changes in the development of disc degeneration. Previous studies demonstrated a role for laminin-presenting biomaterials in promoting a healthy phenotype for human NP cells from degenerated tissue. Here we investigate the use of laminin-mimetic peptides presented individually or in combination on a poly(ethylene) glycol hydrogel as a platform to modulate the behaviors of degenerative human NP cells. Data confirm that NP cells attach to select laminin-mimetic peptides that results in cell signaling downstream of integrin and syndecan binding. Furthermore, the peptide-functionalized hydrogels demonstrate an ability to promote cell behaviors that mimic that of full-length laminins. These results identify a set of peptides that can be used to regulate NP cell behaviors toward a regenerative engineering strategy.
Identifiants
pubmed: 34188794
doi: 10.1177/20417314211021220
pii: 10.1177_20417314211021220
pmc: PMC8211742
doi:
Types de publication
Journal Article
Langues
eng
Pagination
20417314211021220Subventions
Organisme : NIAMS NIH HHS
ID : R01 AR069588
Pays : United States
Informations de copyright
© The Author(s) 2021.
Déclaration de conflit d'intérêts
Declaration of conflicting interests: The author(s) declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article.
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