Hesperidin Modulates Troponin-1 Serum Level and Decrease Heart Tissue Injury of Irradiated Rats.
Heart Injury
Hesperidin
Radiation
Journal
Journal of biomedical physics & engineering
ISSN: 2251-7200
Titre abrégé: J Biomed Phys Eng
Pays: Iran
ID NLM: 101589641
Informations de publication
Date de publication:
Jun 2021
Jun 2021
Historique:
received:
25
06
2018
accepted:
20
08
2018
entrez:
30
6
2021
pubmed:
1
7
2021
medline:
1
7
2021
Statut:
epublish
Résumé
The heart is the major dose-limiting organ for radiotherapy of malignant tumor in the mediastanal region. This study aims to investigate the radio protective effects of Hesperidin (HES) as a natural flavonoid after localized irradiation of the rat's mediastinum region. In this experimental study, we divided sixty male rats into 4 groups (n=15). First group: Sham which received PBS; second group: Hesperidin only (100 mg/kg/day orally) for one week; third group: Radiation that received single dose of 20 Gy gamma radiation using Co-60 unit and the forth group: Radiation+HES that underwent the same dose of radiation and received HES for 7 days prior irradiation. Each group was divided in two branches. Early sampling from subgroup one was done 4-6 hours after irradiation to determine troponin-1 level changes. Rats of second subgroups were killed 56 days after irradiation for histopathological evidence. In radiation group, troponin -1 serum level had a significant increase in comparison with sham group (P<0.05). Histopathological evaluation of second subgroup showed there was a significant difference between sham and radiation group in some parameters. Inflammation (p=0.008), pericardial effusion (P=0.001), and vascular plaque (P=0.001) had an increase in the irradiation group. Oral administration of hesperidin significantly decreased all the above factors when was compared with irradiation group (P>0.016). Oral administration of Hesperidine for seven days prior radiotherapy may decrease troponin-1 and cardiac injury due to radiation.
Sections du résumé
BACKGROUND
BACKGROUND
The heart is the major dose-limiting organ for radiotherapy of malignant tumor in the mediastanal region.
OBJECTIVE
OBJECTIVE
This study aims to investigate the radio protective effects of Hesperidin (HES) as a natural flavonoid after localized irradiation of the rat's mediastinum region.
MATERIAL AND METHODS
METHODS
In this experimental study, we divided sixty male rats into 4 groups (n=15). First group: Sham which received PBS; second group: Hesperidin only (100 mg/kg/day orally) for one week; third group: Radiation that received single dose of 20 Gy gamma radiation using Co-60 unit and the forth group: Radiation+HES that underwent the same dose of radiation and received HES for 7 days prior irradiation. Each group was divided in two branches. Early sampling from subgroup one was done 4-6 hours after irradiation to determine troponin-1 level changes. Rats of second subgroups were killed 56 days after irradiation for histopathological evidence.
RESULTS
RESULTS
In radiation group, troponin -1 serum level had a significant increase in comparison with sham group (P<0.05). Histopathological evaluation of second subgroup showed there was a significant difference between sham and radiation group in some parameters. Inflammation (p=0.008), pericardial effusion (P=0.001), and vascular plaque (P=0.001) had an increase in the irradiation group. Oral administration of hesperidin significantly decreased all the above factors when was compared with irradiation group (P>0.016).
CONCLUSION
CONCLUSIONS
Oral administration of Hesperidine for seven days prior radiotherapy may decrease troponin-1 and cardiac injury due to radiation.
Identifiants
pubmed: 34189126
doi: 10.31661/jbpe.v0i0.969
pii: JBPE-11-3
pmc: PMC8236111
doi:
Types de publication
Journal Article
Langues
eng
Pagination
377-388Informations de copyright
Copyright: © Journal of Biomedical Physics and Engineering.
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