Identification of genes modulated by interferon gamma in breast cancer cells.
Breast cancer
Estrogen receptor
IFNγ
Interferon-stimulated genes
Journal
Biochemistry and biophysics reports
ISSN: 2405-5808
Titre abrégé: Biochem Biophys Rep
Pays: Netherlands
ID NLM: 101660999
Informations de publication
Date de publication:
Sep 2021
Sep 2021
Historique:
received:
16
04
2021
revised:
06
06
2021
accepted:
08
06
2021
entrez:
30
6
2021
pubmed:
1
7
2021
medline:
1
7
2021
Statut:
epublish
Résumé
Interferon gamma (IFNγ) plays a context-dependent dual tumor-suppressor and pro-tumorigenic roles in cancer. IFNγ induces morphological changes in breast cancer (BC) cells with or without estrogen receptor alpha (ERα) expression. However, IFNγ-regulated genes in BC cells remain unexplored. Here, we performed a cDNA microarray analysis of MCF-7 (ERα+) and MDA-MB-231 (HER2-/PR-/ERα-) cells with and without IFNγ treatment. We identified specific IFNγ-modulated genes in each cell type, and a small group of genes regulated by IFNγ common in both cell types. IFNγ treatment for an extended time mainly repressed gene expression shared by both cell types. Nonetheless, some of these IFNγ-repressed genes were seemingly deregulated in human mammary tumor samples, along with decreased
Identifiants
pubmed: 34189281
doi: 10.1016/j.bbrep.2021.101053
pii: S2405-5808(21)00147-3
pmc: PMC8220005
doi:
Types de publication
Journal Article
Langues
eng
Pagination
101053Informations de copyright
© 2021 The Authors.
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