A CRMP4-dependent retrograde axon-to-soma death signal in amyotrophic lateral sclerosis.
ALS
CRMP4
axonal transport
dynein
retrograde signaling
Journal
The EMBO journal
ISSN: 1460-2075
Titre abrégé: EMBO J
Pays: England
ID NLM: 8208664
Informations de publication
Date de publication:
01 09 2021
01 09 2021
Historique:
revised:
11
05
2021
received:
23
12
2020
accepted:
28
05
2021
pubmed:
1
7
2021
medline:
30
11
2021
entrez:
30
6
2021
Statut:
ppublish
Résumé
Amyotrophic lateral sclerosis (ALS) is a fatal non-cell-autonomous neurodegenerative disease characterized by the loss of motor neurons (MNs). Mutations in CRMP4 are associated with ALS in patients, and elevated levels of CRMP4 are suggested to affect MN health in the SOD1
Identifiants
pubmed: 34190355
doi: 10.15252/embj.2020107586
pmc: PMC8408612
doi:
Substances chimiques
Dpysl3 protein, mouse
0
Nerve Tissue Proteins
0
Sod1 protein, mouse
EC 1.15.1.1
Superoxide Dismutase-1
EC 1.15.1.1
Dyneins
EC 3.6.4.2
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
e107586Subventions
Organisme : NIA NIH HHS
ID : P30 AG053760
Pays : United States
Organisme : NIA NIH HHS
ID : P30 AG072931
Pays : United States
Informations de copyright
© 2021 The Authors. Published under the terms of the CC BY NC ND 4.0 license.
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